Metabolic improvements during weight loss: The RNPC® cohort

Christensen, Lars; Thorning, Tanja Kongerslev; Fabre, Odile; Legrand, Rémy; Astrup, Arne; Hjorth, Mads F.

doi:10.1016/j.obmed.2019.100085

Cited by 5 publications

(2 citation statements)

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“…RNPC© (for Rééducation Nutritionnelle et Psycho-Comportementale, i.e., the Nutritional Psycho-Behavioral Reeducation) program, based on a high-protein, low-carbohydrate, and low-fat diet, has already proven to be an efficient [6] and cost-effective [12] weight loss intervention with significant improvement in metabolic parameters following its weight loss phase [13]. The main objective of this study was to assess whether the RNPC© program is associated with a modification of patients' Modification of Diet in Renal Disease (MDRD) equation-based estimated glomerular filtration rate (eGFR) during the program high-protein phases, i.e., weight loss and early stabilization phases.…”

Section: Introductionmentioning

confidence: 99%

A Specific High-Protein Weight Loss Program Does Not Impair Renal Function in Patients Who Are Overweight/Obese

et al. 2022

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Although high-protein diets appear to be the most efficient way to lose weight, concerns may arise about their innocuity on renal function. The objective of this study is to assess the impact of a weight loss program on renal function. A multicentric cohort-based study was performed using the RNPC© French national weight loss program. Patients with at least two creatinine measurements at the beginning of the program and at the end of the weight loss phase between 1 January 2016 and 1 July 2021 were included. Renal function was assessed by Modification of Diet in Renal Disease (MDRD) equation-based estimated glomerular filtration rate (eGFR). From 4394 patients with two creatinine measurements included, 1579 (35.9%) had normal eGFR (MDRD 90–120 mL/min/1.73 m2), 210 (4.8%) had hyperfiltration (MDRD > 120 mL/min/1.73 m2), 2383 (54.2%) had chronic kidney disease (CKD) grade 2 (MDRD 60–90 mL/min/1.73 m2), and 221 (5.0%) had CKD grade 3 (MDRD 30–60 mL/min/1.73 m2). Multivariable analyses showed no eGFR change for patients in initial CKD grade 2, normal eGFR and hyperfiltration, and a significant increase in CKD grade 3. The RNPC© program avoids renal function impairment during the two first phases, regardless of the initial eGFR.

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Section: Introductionmentioning

confidence: 99%

A Specific High-Protein Weight Loss Program Does Not Impair Renal Function in Patients Who Are Overweight/Obese

et al. 2022

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“…All may positively reduce cardiovascular disease and DM2 risk in people with metabolic syndrome. Therefore, managing Mets with a low carbohydrate diet has an outstanding reputation as an excellent approach to managing metabolic syndrome ( 14–16 ). Furthermore, studies have shown that LCD can improve indicators of metabolic syndromes, such as blood pressure control, blood sugar control, and maintaining optimal cholesterol level(s) ( 1 , 17 ).…”

Section: Introductionmentioning

confidence: 99%

The effect of a nurse-led low carbohydrate regimen on anthropometric and laboratory parameters of patients with metabolic syndrome: a quasi-experimental study

Abdulghani,

Al-Fayyadh

2024

Front. Public Health

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IntroductionMetabolic syndrome is a global health concern. It is a condition that includes a cluster of various risk factors for type 2 diabetes and cardiovascular disease. This quasi-experimental study investigates the effect of a nurse-led low-carbohydrate regimen on anthropometric and laboratory parameters in metabolic syndrome patients.MethodsThe study used a quasi-experimental design conducted at the University of Mosul; 128 participants meeting the metabolic syndrome criteria were recruited and divided into the intervention and control groups. The intervention group received personalized counseling and support in implementing a low-carb regime, while the control group received standard advice. The study participants were assessed by anthropometry, and laboratory parameters were evaluated pre- and post-intervention. Statistical data analysis was conducted using IBM-SPSS 27, including chi-square, Fisher’s exact test, t-tests, and the Mcnemar test, which were performed to compare the changes within and between groups.ResultsThe mean age of the participants in the intervention and control groups was 50.72 ± 6.43 years and 49.14 ± 6.89 years, respectively. Compared to the control group, the intervention group experienced a significant positive reduction in anthropometric measures and laboratory parameters, including weight, body mass index (BMI), waist circumference, lipid profiles, and HbA1c.ConclusionA tangible effect of nurse-led interventions based on low-carbohydrate regimens in managing metabolic syndrome was empirically authenticated. Positive changes were observed in the intervention group regarding anthropometric measures and laboratory parameters. However, future research may require a larger sample size and a longer follow-up to confirm these effects and evaluate long-term metabolic impacts.

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Weight loss following an intensive dietary weight loss program in obese candidates for bariatric surgery: The retrospective RNPC® cohort

et al. 2019

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Metabolic improvements during weight loss: The RNPC® cohort

Cited by 5 publications

References 25 publications

A Specific High-Protein Weight Loss Program Does Not Impair Renal Function in Patients Who Are Overweight/Obese

A Specific High-Protein Weight Loss Program Does Not Impair Renal Function in Patients Who Are Overweight/Obese

The effect of a nurse-led low carbohydrate regimen on anthropometric and laboratory parameters of patients with metabolic syndrome: a quasi-experimental study

Weight loss following an intensive dietary weight loss program in obese candidates for bariatric surgery: The retrospective RNPC® cohort

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