Metabolic influences on T cell in psoriasis: a literature review

Abstract

Psoriasis is a systemic inflammatory disease that frequently coexists with various other conditions, such as essential hypertension, diabetes, metabolic syndrome, and inflammatory bowel disease. The association between these diseases may be attributed to shared inflammatory pathways and abnormal immunomodulatory mechanisms. Furthermore, metabolites also play a regulatory role in the function of different immune cells involved in psoriasis pathogenesis, particularly T lymphocytes. In this review, we have summarized the current research progress on T cell metabolism in psoriasis, encompassing the regulation of metabolites in glucose metabolism, lipid metabolism, amino acid metabolism, and other pathways within T cells affected by psoriasis. We will also explore the interaction and mechanism between psoriatic metabolites and immune cells. Moreover, we further discussed the research progress of metabolomics in psoriasis to gain a deeper understanding of its pathogenesis and identify potential new therapeutic targets through identification of metabolic biomarkers associated with this condition.

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“…Research has also delved into the metabolic influences on T cells in psoriasis, examining how psoriasis affects the regulation of metabolites in glucose metabolism, lipid metabolism, amino acid metabolism, and other pathways within T cells. This highlights the systemic nature of psoriasis, affecting various metabolic processes beyond the skin ( Su et al, 2023 ). Abnormal lipid distribution was also observed in patients with psoriasis increases their risk for atherosclerosis.…”