Metabolic iron detection through divalent metal transporter 1 and ferroportin mediated cocktail fluorogenic probes

Zhao, Yu-Qiang; Duan, Jiahong; Yu, Le; Kim, Ilwha; Wang, Yumin; Ma, Yi‐Cheng; Zou, Cheng‐Gang; Zhou, Ying; Zhang, Jun Feng; Kim, Jong Seung

doi:10.1039/d1cc03150c

Cited by 1 publication

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“…42 Through transformation between the ferrous (Fe 2+ ) and ferric (Fe 3+ ) forms, iron plays key roles in many biological activities such as oxygen transport and promoting oxidative stress via the Fenton reaction. 43 Therefore, the development of methods for accurate discrimination of Fe 3+ and Fe 2+ is meaningful for investigating their biological roles. Considering these, pure Fe 3+ and Fe 2+ and mixed Fe 3+ /Fe 2+ in ratios of 1:4, 2:3, and 4:1 in 5% serum were submitted to X1SA for discrimination.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Among the tested metal ions, iron attracted our attention since it is the most abundant transitional metal in our human body . Through transformation between the ferrous (Fe 2+ ) and ferric (Fe 3+ ) forms, iron plays key roles in many biological activities such as oxygen transport and promoting oxidative stress via the Fenton reaction . Therefore, the development of methods for accurate discrimination of Fe 3+ and Fe 2+ is meaningful for investigating their biological roles.…”

Section: Results and Discussionmentioning

confidence: 99%

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Rotating the C–N Bond in a Coumarin–Pyridine-Based Sensor for Pattern Recognition of Versatile Metal Ions

Cao

Wan

et al. 2021

Anal. Chem.

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A cross-reactive sensor array is powerful for high-throughput discrimination of various kinds of metal ions. However, the construction of a multicomponent sensor array is always time-consuming and cost-ineffective. Herein, a practical four-component X1-based sensor array (X1SA) was obtained by simply dissolving a single dye molecule X1 in respective solvents such as methanol, ethanol, dimethyl sulfoxide, and acetonitrile. In this design, X1 exhibits strong solvatochromic fluorescence properties via an excited-state intramolecular proton transfer and intramolecular charge transfer combined mechanism. Moreover, rotation of the C− N bond between the pyridine and coumarin units in X1 enabled it to coordinate with metal ions through different binding modes, which acted as an additional dimension of the sensor array. Inspired by this C−N bond rotation strategy, X1SA was determined to be powerful in discriminating 20 kinds of metal ions in both phosphate-buffered saline and 5% serum media in a range of 0.1−100 μM. In addition, the sensor array was also successfully applied in differentiating similar and mixed metal ions such as Fe 3+ /Fe 2+ , Cd 2+ /Hg 2+ , and Sn 2+ /Pb 2+ in serum samples, which is meaningful for investigating the biological roles of iron and early diagnosis of related metal poisoning accidents.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Results and Discussionmentioning

confidence: 99%

Rotating the C–N Bond in a Coumarin–Pyridine-Based Sensor for Pattern Recognition of Versatile Metal Ions

Cao

Wan

et al. 2021

Anal. Chem.

View full text Add to dashboard Cite

show abstract

Metabolic iron detection through divalent metal transporter 1 and ferroportin mediated cocktail fluorogenic probes

Abstract: A cocktail [1+2] dual-fluorescent probe system was developed to realize the real-time visualization of dynamic iron state changes between Fe2+ and Fe3+ at the cellular level and multicellular organisms, providing...

Cited by 1 publication

References 21 publications

Rotating the C–N Bond in a Coumarin–Pyridine-Based Sensor for Pattern Recognition of Versatile Metal Ions

Rotating the C–N Bond in a Coumarin–Pyridine-Based Sensor for Pattern Recognition of Versatile Metal Ions

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