2022
DOI: 10.1126/scitranslmed.abn2956
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Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency

Abstract: Individuals with glucose transporter type I deficiency (G1D) habitually experience nutrient-responsive epilepsy associated with decreased brain glucose. However, the mechanistic association between blood glucose concentration and brain excitability in the context of G1D remains to be elucidated. Electroencephalography (EEG) in G1D individuals revealed nutrition time-dependent seizure oscillations often associated with preserved volition despite electrographic generalization and uniform average oscillation dura… Show more

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Cited by 18 publications
(70 citation statements)
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“…Only modest glucose transport increases such as those experienced postprandially are beneficial to G1D patients (von Moers et al, 2002;Akman et al, 2010;Koy et al, 2011;Parolin et al, 2011;Rajasekaran et al, 2022). This suggests that relatively small (i.e., below two-fold) changes in net glucose transport can significantly ameliorate brain dysfunction in G1D.…”
Section: Discussionmentioning
confidence: 99%
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“…Only modest glucose transport increases such as those experienced postprandially are beneficial to G1D patients (von Moers et al, 2002;Akman et al, 2010;Koy et al, 2011;Parolin et al, 2011;Rajasekaran et al, 2022). This suggests that relatively small (i.e., below two-fold) changes in net glucose transport can significantly ameliorate brain dysfunction in G1D.…”
Section: Discussionmentioning
confidence: 99%
“…Wild-type C57BL/6J mice were purchased from the Jackson Laboratory. G1D mice were previously described (Marin-Valencia et al, 2012;Rajasekaran et al, 2022). These mice uniformly display frank ataxia with normal lifespan and other habits.…”
Section: Mouse Modelmentioning
confidence: 99%
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