Metabolic monitoring of obese children born small for gestational age

Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age

“…Babies that are born SGA have often experienced IUGR. Indeed, it is well established that IUGR and SGA are associated not only with increased perinatal morbidity and mortality but also with adverse long‐term health sequelae such as hypertension, coronary heart disease, dyslipidaemia, visceral obesity, impaired glucose tolerance and type 2 diabetes . Notably, metabolic risk is mainly influenced by the pattern of early growth.…”

Overweight, Obesity, and Body Composition in 3.5- and 7-Year-Old Swedish Children Born with Marginally Low Birth Weight

“…[6][7][8] Particularly, the roles of LBW, preterm birth, and intrauterine growth restriction (IUGR) have been explored and discussed. [8][9][10][11] In common for many infants born too early or too small is an increased growth velocity at some point after birth. Mismatch in nutrition, resulting in poor prenatal growth followed by accelerated postnatal growth triggered by overnutrition, may be a particularly important link in the causal chain of metabolic programming.…”

Metformin; a review of its history and future: from lilac to longevity

“…Finally, a small study was conducted to determine if metformin could prevent adiposity in prepubertal children who were born small for gestational age and had rapid catch up growth. This group of children is typically at increased risk for metabolic diseases in adulthood . In this study metformin administration at a low dose (425 mg daily) for 24 months improved abdominal fat as measured by MRI, triglycerides, and insulin resistance as measured by HOMA‐IR …”