Metabolic myopathy

Thomas, P K

doi:10.1136/pgmj.43.496.103

Cited by 4 publications

(1 citation statement)

References 59 publications

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“…5, and compared with the response obtained with a similar dosage of calciferol in 20 boys and 10 girls of the total of 70 who presented separately with proved rickets (based on bone biopsy and/or Looser's zones and raised alkaline phosphatase). Non-specific symptoms of lassitude, muscle weakness, aches, and pains as described by other workers (Prineas et al, 1965;Thomas, 1967;Ford et al, 1972b) were relieved by therapy, often in a sufficiently striking manner to be commented on by their teachers. A full report on the results of therapy will be presented when the follow-up study is completed.…”

Section: Resultsmentioning

confidence: 80%

Serum Alkaline Phosphatase and Rickets in Urban Schoolchildren

Cooke¹,

Swan²,

Asquith³

et al. 1973

BMJ

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Since the decline of the widespread supplementation of the diet with vitamin D, the demands of the physiological growth spurt for extra vitamin D in adolescents already on a borderline intake may be responsible for the great increase in "biochemical" rickets. Once the growth spurt is over the condition subsides but the results ofimpaired growth or permanent pelvic deformity will not necessarily be eradicated.

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Section: Resultsmentioning

confidence: 80%

Serum Alkaline Phosphatase and Rickets in Urban Schoolchildren

Cooke¹,

Swan²,

Asquith³

et al. 1973

BMJ

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Nature of muscular change in osteomalacia: Light‐ and electron‐microscope observations

Dastur¹,

Gagrat²,

Wadia³

et al. 1975

The Journal of Pathology

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Thirteen muscle biopsy specimens (mainly the gluteus maximus) from 12 patients with laboratory confirmation of osteomalacia and proximal muscle weakness in 10 were examined by light and electron microscopy. Light microscopy revealed mild diffuse non-specific atrophy of the muscle fibres in 10 cases, severe generalised atrophy in one and patchy group atrophy in one. There was no myopathic change in specimens from cases with either a nutritional aetiology, or a mixed aetiology. The former, mostly women gave a history of severe chronic malnutrition often accompanied by repeated pregnancies and prolonged lactation; those with a mixed aetiology gave, in addition, evidence of a metabolic or endocrine disorder such as hyperparathyroidism, hyperthyroidism, uraemia, or treatment with anti-epileptic drugs or were of uncertain origin. Electron-microscope examination of muscle from the nutritional group showed atrophic changes in the fibres, such as loss of myofibrils, prominence of mitochondria and glycogen, loosening and folding of the basement-membrane but good preservation of the remaining myofibrils. In contrast muscle from cases of mixed aetiology showed, in addition to the atrophic features, clear degenerative changes in the myofibrils and the mitochondria, accumulation of amorphous material at the site of myofibrillar loss and of lipofuscin in muscle fibres, vascular endothelium and satellite cells. The earliest degenerative change was in the "I" band, involving actin filaments and "Z" line. The triads were generally preserved but the sarcoplasmic reticulum appeared affected in a patient with tetany and severe mitochondrial degeneration. In a patient with thyrotoxicosis, proliferation of central nuclei, "Z" line streaming and formation of "T" tubular aggregates were seen. In one patient with hyperparathyroidism and hypercalcaemia, severe myofibrillar degeneration and mitochondria showing osmiophilic deposits, possibly of calcium phosphate, were encountered. It is concluded: (1) that all osteomalacic muscle weakness is not myopathic but a non-specific atrophy occurring probably on the basis of disuse and malnutrition, and (2) patients with an added metabolic or endocrinological disorder show in addition to the atrophy, degenerative changes in the muscle fibre and its sub-cellular components consistent with myopathy, and these patients should be clearly distinguished from those with a background of malnutrition only.

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Quaternary ammonium salts — advances in chemistry and pharmacology since 1960

Cavallito

1980

Progress in Drug Research / Fortschritte Der Arzneimittelforschung / Progrès Des Recherches Pharmaceutiques

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Metabolic myopathy

Cited by 4 publications

References 59 publications

Serum Alkaline Phosphatase and Rickets in Urban Schoolchildren

Serum Alkaline Phosphatase and Rickets in Urban Schoolchildren

Nature of muscular change in osteomalacia: Light‐ and electron‐microscope observations

Quaternary ammonium salts — advances in chemistry and pharmacology since 1960

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