Metabolic perturbations in pregnant rats exposed to low-dose perfluorooctanesulfonic acid: An integrated multi-omics analysis

Proteomics analysis of plasm exosomes in early pregnancy among normal pregnant women and those with antiphospholipid syndrome

“…Moreover, KEGG analysis revealed that the DEPs were significantly enriched in the PPAR signaling pathway, which consists of three subtypes [ 34 ]. Previous studies have indicated that PPARγ is expressed in the placenta and exerts a significant impact on both its development and function [ 35 ].…”

First trimester plasma per- and Polyfluoroalkyl Substances (PFAS) and blood pressure trajectories across the second and third trimesters of pregnancy

“…Shallow trophoblast invasion is associated with poor remodeling of the spiral arteries and an increase in maternal blood pressure ( Burton and Jauniaux, 2018 ). PFAS, particularly PFOS ( Yu et al, 2023 ), are known to activate peroxisome proliferator active receptors (central regulators of trophoblast differentiation), leading to abnormal trophoblast invasion via placental ischemia, angiogenic factor imbalance, and, ultimately, endothelial dysfunction ( Fournier et al, 2007 ; Tsang et al, 2013 ).…”