Metabolic phenotype and adipose and liver features in a high-fat Western diet-induced mouse model of obesity-linked NAFLD

Luo, Yuqi; Burrington, Christine M.; Graff, Emily C.; Zhang, Jian; Judd, Robert L.; Suksaranjit, Promporn; Kaewpoowat, Quanhathai; Davenport, Samantha K.; O’Neill, Ann Marie; Greene, Michael W.

doi:10.1152/ajpendo.00319.2015

Cited by 71 publications

(50 citation statements)

References 45 publications

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“…[43][44][45] Particularly, pervious researches have suggested that excess intake of fat-rich diet may cause hyperlipemia and intestinal endotoxemia, resulting in blood lipid metabolism disorder and systemic inflammation, ultimately contributing to the development of CKD and NAFLD. [46][47][48] Thus, kidney disease caused by eating habits has widely received enough attention by the researchers. HFD-induced metabolic abnormalities would change kidney-related gene expression …”

Section: Discussionmentioning

confidence: 99%

Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kB signaling and Nrf2 pathway in high fat diet fed mice

Xu¹,

Wang²,

Yang³

2017

IJN

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Section: Discussionmentioning

confidence: 99%

Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kB signaling and Nrf2 pathway in high fat diet fed mice

Xu¹,

Wang²,

Yang³

2017

IJN

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“…The entire surface area of each fat pad was counted to provide a total number of crown‐like structures per fat pad. Adipocyte area was determined as previously described .…”

Section: Methodsmentioning

confidence: 99%

Dietary Methionine Restriction Reduces Inflammation Independent of FGF21 Action

Sharma

Dixon

Jung

et al. 2019

Obesity

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Objective: Methionine restriction (MR) decreases inflammation and improves markers of metabolic disease in rodents. MR also increases hepatic and circulating concentrations of fibroblast growth factor 21 (FGF21). Emerging evidence has suggested that FGF21 exerts anti-inflammatory effects. The purpose of this study was to determine the role of FGF21 in mediating the MR-induced reduction in inflammation. Methods: Wild-type and Fgf21 -/mice were fed a high-fat (HF) control or HF-MR diet for 8 weeks. In a separate experiment, mice were fed a HF diet (HFD) for 10 weeks. Vehicle or recombinant FGF21 (13.6 µg/d) was administered via osmotic minipump for an additional 2 weeks. Inflammation and metabolic parameters were measured. Results: Fgf21 -/mice were more susceptible to HFD-induced inflammation, and MR reduced inflammation in white adipose tissue (WAT) and liver of Fgf21 -/mice. MR downregulated activity of signal transducer and activator of transcription 3 in WAT of both genotypes. FGF21 administration reduced hepatic lipids and blood glucose concentrations. However, there was little effect of FGF21 on inflammatory gene expression in liver or adipose tissue or circulating cytokines. Conclusions: MR reduces inflammation independent of FGF21 action. Endogenous FGF21 is important to protect against the development of HFD-induced inflammation in liver and WAT, yet administration of lowdose FGF21 has little effect on markers of inflammation.

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“…In a study by Luo et al, researchers used a WD mouse model that consisted of high fat content (40% of energy from fat with 30% of fat from lard, 30% from butterfat, and 30% from Crisco) and liquid fructose and sucrose (42 g/L total at a ratio of 55% fructose to 45% sucrose) 75 . Researchers found that this diet caused increased glucose intolerance, insulin resistance and adipose tissue dysfunction 75 . In addition, there were increased levels of intrahepatic triglycerides, plasma ALT, liver weight, hepatic fibrosis and hepatic inflammation 75 .…”

Section: Western-like Diet (Wd)mentioning

confidence: 99%

“…Researchers found that this diet caused increased glucose intolerance, insulin resistance and adipose tissue dysfunction 75 . In addition, there were increased levels of intrahepatic triglycerides, plasma ALT, liver weight, hepatic fibrosis and hepatic inflammation 75 . This diet resulted in similar results as the WD consisting of high fat, cholesterol, and one type of sugar (either fructose or glucose) making it a reasonable mouse model option as it also induced NASH with fibrosis and features of metabolic syndrome.…”

Section: Western-like Diet (Wd)mentioning

confidence: 99%

Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights

et al. 2018

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Non-alcoholic fatty liver disease (NAFLD) is a disease of increasing interest as its prevalence is on the rise. NAFLD has been linked to metabolic syndrome, which is becoming more common due to the Western diet. Since NAFLD can lead to cirrhosis and related complications including hepatocellular carcinoma, the increasing prevalence is concerning and medical therapy aimed at treating NAFLD is of great interest. Researchers studying the effects of medical therapy on NAFLD use dietary mouse models. The two main types of mouse model diets are the methionine- and choline-deficient (MCD) diet and Western-like Diet (WD). Although both induce NAFLD, the mechanisms are very different. We reviewed several studies conducted within the last 5 years that use MCD diet or WD mouse models in order to mimic this disease in a way most similar to humans. The MCD diet inconsistently induces NAFLD and fibrosis and doesn’t completely induce metabolic syndrome. Thus, the clinical significance of the MCD diet is questionable. In contrast, WD mouse models consisting of high fat, cholesterol, and a combination of high fructose corn syrup, sucrose, fructose or glucose not only lead to metabolic syndrome but also induce NAFLD with fibrosis making these choices most suitable for research.

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Metabolic phenotype and adipose and liver features in a high-fat Western diet-induced mouse model of obesity-linked NAFLD

Abstract: Luo Y, Burrington CM, Graff EC, Zhang J, Judd RL, Suksaranjit P, Kaewpoowat Q, Davenport SK, O'Neill AM, Greene MW. Metabolic phenotype and adipose and liver features in a high-fat Western diet-induced mouse model of obesity-linked NAFLD.

Cited by 71 publications

References 45 publications

Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kB signaling and Nrf2 pathway in high fat diet fed mice

Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kB signaling and Nrf2 pathway in high fat diet fed mice

Dietary Methionine Restriction Reduces Inflammation Independent of FGF21 Action

Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights

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