Metabolic Planar Imaging Using &lt;sup&gt;123&lt;/sup&gt;I-&lt;i&gt;β&lt;/i&gt;-Methyl-Iodophenyl Pentadecanoic Acid Identifies Myocardial Ischemic Memory After Intracoronary Acetylcholine Provocation Tests in Patients With Vasospastic Angina

Yoneyama, Kihei; Akashi, Yoshihiro J.; Kida, Kenji; Ashikaga, Kohei; Musha, Haruki; Suzuki, Kazuhiro; Harada, Tomoo; Miyake, Fumihiko

doi:10.1536/ihj.13-180

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…While this method is non-invasive, it is expensive from a medical economics perspective. 31) MDA-LDL, 21) which is modified LDL-C, is a known oxidative stress marker, 22) and the serum MDA-LDL level increases in patients complicated by smoking 23) or DM. 24) It is conceivable that the oxidative marker MDA-LDL may be associated with endothelial dysfunction in the mechanism of VSA because oxidative stress can generally induce endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Malondialdehyde-Modified Low Density Lipoprotein as Oxidative-Stress Marker in Vasospastic Angina Patients

et al. 2017

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SummaryVasospastic angina (VSA) is caused by endothelial dysfunction and hypercontraction of vascular smooth muscle cells. Although oxidative-stress can induce endothelial dysfunction, the relationship of VSA and the oxidative-stress marker malondialdehyde-modified low density lipoprotein (MDA-LDL) remains unclear. Purpose: Serum MDA-LDL was evaluated in candidate VSA patients.The subjects were 84 patients admitted to our hospital because of chest pain at rest. We stratified the patients into 3 groups; definite VSA, suspected VSA, and unlikely VSA according to a Japanese Circulation Society (JCS) guideline. The patients classified as definite VSA or suspected VSA were considered as "clinical VSA".Forty cases were classified as definite VSA, 35 as suspected VSA, and 9 as unlikely VSA. Thus, clinical VSA was the diagnosis in 75 cases. The patient characteristics showed that the average age of the patients was 60.2 years old (men, 61%). The serum MDA-LDL level of the clinical VSA group (126.3 ± 38.0 U/L) was significantly higher than the unlikely VSA group (98.7 ± 31.1 U/L). Serum MDA-LDL was positively correlated with total cholesterol (T-Chol), lowdensity lipoprotein cholesterol (LDL-C), triglycerides, and fasting blood glucose. Multivariate analysis showed that serum MDA-LDL was the most predictive marker for making a diagnosis of clinical VSA (Odds ratio 1.064, 95% confidence interval 1.014-1.145, P = 0.008). In a population with positive or borderline ECG change, the positive rate in the acetylcholine provocation test was significantly higher in the MDA-LDL higher group compared to the MDA-LDL lower group (81% versus 37%, P = 0.032).: Serum MDA-LDL might be a useful biomarker of VSA and have additional value for the diagnosis of clinical VSA. (Int Heart J 2017; 58: 335-343)

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Section: Discussionmentioning

confidence: 99%

Malondialdehyde-Modified Low Density Lipoprotein as Oxidative-Stress Marker in Vasospastic Angina Patients

et al. 2017

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“…Long-chain fatty acids are major cardiac energy substrates and fatty acids imaging is considered to be a sensitive method to detect ischemic memory [27,28]. In patients with coronary spasm, we performed fatty acid metabolic imaging with BMIPP to clarify the ischemic area as a diagnostic tool.…”

Section: I-bmippmentioning

confidence: 99%

Clinical usefulness of myocardial scintigraphy in patients with vasospastic angina

Sueda

2020

Journal of Cardiology

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Background: Myocardial scintigraphy is defined as class IIb in the Japanese Circulation Society guideline for diagnosis of vasospastic angina (VSA). However, Caucasian guidelines had no classification of cardiac scintigraphy for diagnosis of VSA. Objectives: To clarify the clinical usefulness of myocardial scintigraphy, we analyzed the sensitivity and specificity of each cardiac scintigraphy. Methods: We extracted the 136 papers of myocardial scintigraphy from the PubMed database from 1980 to 2018 in patients with VSA. Finally we analyzed the 88 papers including 33 papers of 201thallium (Tl), 10 papers of 123 I beta-methyl 15-para-iodophenyl 3(R, S)-methylpentadecanoic acid (BMIPP), 9 papers of 123 I-metaiodobenzylguanidine (MIBG), 4 papers of 99m Tc-sestamibi (MIBI: methoxy-isobutylisonitrile), and 2 papers of tetrofosmin to investigate the sensitivity and specificity of each tracer. Results: Tl, BMIPP, or MIBG cardiac scintigraphy were useful to diagnose patients with VSA, because sensitivity was 57-73%. Specificity was 55-83%. Sensitivity of left circumflex artery was significantly lower than other vessels. BMIPP imaging may be helpful for clinical course of VSA. However, myocardial scintigraphic abnormal findings may not always show the ischemic memory due to coronary artery spasm. Conclusions: Recent cardiologists do not perform hyperventilation tests or MIBG scintigraphy for diagnosis of coronary spasm. After understanding the flow of the times, cardiologists should use Tl or BMIPP myocardial scintigraphy for VSA as one of supplementary tools in the real world.

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“…Single photon emission computed tomography (SPECT) images are often acquired to evaluate regional myocardial uptake patterns. 12,16) The common semi-quantitative indices used for the interpretation of cardiac sympathetic nerve images are the heart to mediastinum ratio (H/M) and washout rate (WR). The H/M ratio is determined from anterior planar delayed 123 I-MIBG images ( Figure 1).…”

Section: I-mibgmentioning

confidence: 99%

Usefulness of Cardiac Sympathetic Nerve Imaging Using <sup>123</sup>Iodine-Metaiodobenzylguanidine Scintigraphy for Predicting Sudden Cardiac Death in Patients With Heart Failure

2016

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SummaryThe autonomic nervous system plays an important role in the human heart. Activation of the cardiac sympathetic nervous system is a cardinal pathophysiological abnormality associated with the failing human heart. Myocardial imaging using 123 I-metaiodobenzylguanidine (MIBG), an analog of norepinephrine, can be used to investigate the activity of norepinephrine, the predominant neurotransmitter of the sympathetic nervous system. Many clinical trials have demonstrated that 123 I-MIBG scintigraphic parameters predict cardiac adverse events, especially sudden cardiac death, in patients with heart failure. In this review, we summarize results from published studies that have focused on the use of cardiac sympathetic nerve imaging using 123 I-MIBG scintigraphy for risk stratification of sudden cardiac death in patients with heart failure. (Int Heart J 2016; 57: 140-144)

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Metabolic Planar Imaging Using <sup>123</sup>I-<i>β</i>-Methyl-Iodophenyl Pentadecanoic Acid Identifies Myocardial Ischemic Memory After Intracoronary Acetylcholine Provocation Tests in Patients With Vasospastic Angina

Cited by 8 publications

References 25 publications

Malondialdehyde-Modified Low Density Lipoprotein as Oxidative-Stress Marker in Vasospastic Angina Patients

Malondialdehyde-Modified Low Density Lipoprotein as Oxidative-Stress Marker in Vasospastic Angina Patients

Clinical usefulness of myocardial scintigraphy in patients with vasospastic angina

Usefulness of Cardiac Sympathetic Nerve Imaging Using <sup>123</sup>Iodine-Metaiodobenzylguanidine Scintigraphy for Predicting Sudden Cardiac Death in Patients With Heart Failure

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