Metabolic profile changes in serum of migraine patients detected using 1H-NMR spectroscopy

Harder, Aster V. E.; Vijfhuizen, Lisanne S.; Henneman, Peter; Dijk, Ko Willems van; Duijn, Cornelia M. van; Terwindt, Gisela M.; Maagdenberg, Arn M. J. M. van den

doi:10.1186/s10194-021-01357-w

Cited by 8 publications

(7 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, an additional study investigating the genetic underpinning and causality of the 316 blood metabolites and migraine risk revealed a significant correlation between migraine and 44 metabolites, largely organic acid and lipid metabolic traits (90). Changes in metabolite levels are in line with recent metabolomics studies in the blood of migraine patients (91,92).…”

Section: Genetic Relation With Comorbid Disorderssupporting

confidence: 85%

Migraine genetics: Status and road forward

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background Migraine is considered a multifactorial genetic disorder. Different platforms and methods are used to unravel the genetic basis of migraine. Initially, linkage analysis in multigenerational families followed by Sanger sequencing of protein-coding parts (exons) of genes in the genomic region shared by affected family members identified high-effect risk DNA mutations for rare Mendelian forms of migraine, foremost hemiplegic migraine. More recently, genome-wide association studies testing millions of DNA variants in large groups of patients and controls have proven successful in identifying many dozens of low-effect risk DNA variants for the more common forms of migraine with the number of associated DNA variants increasing steadily with larger sample sizes. Currently, next-generation sequencing, utilising whole exome and whole genome sequence data, and other omics data are being used to facilitate their functional interpretation and the discovery of additional risk factors. Various methods and analysis tools, such as genetic correlation and causality analysis, are used to further characterise genetic risk factors. Findings We describe recent findings in genome-wide association studies and next-generation sequencing analysis in migraine. We show that the combined results of the two most recent and most powerful migraine genome-wide association studies have identified a total of 178 LD-independent ( r2 < 0.1) genome-wide significant single nucleotide polymorphisms (SNPs), of which 99 were unique to Hautakangas et al., 11 were unique to Choquet et al., and 68 were identified by both studies. When considering that Choquet et al. also identified three SNPs in a female-specific genome-wide association studies then these two recent studies identified 181 independent SNPs robustly associated with migraine. Cross-trait and causal analyses are beginning to identify and characterise specific biological factors that contribute to migraine risk and its comorbid conditions. Conclusion This review provides a timely update and overview of recent genetic findings in migraine.

show abstract

Section: Genetic Relation With Comorbid Disorderssupporting

confidence: 85%

Migraine genetics: Status and road forward

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nonetheless, our results aligned with some experiences reported in the literature. Altered levels of certain metabolites, such as cholesterol, glucose, pyruvate, and specific amino acids (leucine, isoleucine, methionine, valine, proline, and serine), have been found in subjects with a migraine [ 41 ]. These amino acid alterations, along with tryptophan and serotonin hypometabolism, have been implicated in determining detectable changes in a migraine brain [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Imaging Correlates between Headache and Breast Cancer: An [18F]FDG PET Study

Antunovic,

Artesani,

Viganò

et al. 2023

Cancers

View full text Add to dashboard Cite

This study aimed to examine brain metabolic patterns on [18F]Fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) in breast cancer (BC), comparing patients with tension-type headache (TTH), migraine (MiG), and those without headache. Further association with BC response to neoadjuvant chemotherapy (NAC) was explored. In this prospective study, BC patients eligible for NAC performed total-body [18F]FDG PET/CT with a dedicated brain scan. A voxel-wise analysis (two-sample t-test) and a multiple regression model were used to compare brain metabolic patterns among TTH, MiG, and no-headache patients and to correlate them with clinical covariates. A single-subject analysis compared each patient’s brain uptake before and after NAC with a healthy control group. Primary headache was diagnosed in 39/46 of BC patients (39% TTH and 46% MiG). TTH patients exhibited hypometabolism in specific brain regions before NAC. TTH patients with a pathological complete response (pCR) to NAC showed hypermetabolic brain regions in the anterior medial frontal cortex. The correlation between tumor uptake and brain metabolism varied before and after NAC, suggesting an inverse relationship. Additionally, the single-subject analysis revealed that hypometabolic brain regions were not present after NAC. Primary headache, especially MiG, was associated with a better response to NAC. These findings suggest complex interactions between BC, headache, and hormonal status, warranting further investigation in larger prospective cohorts.

show abstract

“…For CPMG spectra, each spectrum over the range of 8 0.4–4.4 was integrated into segments of equal width (0.01 ppm). The spectrum between δ 5.2-8.5 was discarded due to the week signal of aromatic amino acids and the potential lack of association with migraine according to previous studies (Dejong et al .,2007; Harder et al .,2021). For BPP-LED data, each spectrum over the range of 8 0.1–6.0 was segmented into integral regions of equal width (0.01ppm).…”

Section: Methodsmentioning

confidence: 99%

Metabolomics reveals reasons for the efficacy of acupuncture in migraine patients: The role of anaerobic glycolysis and mitochondrial citrate in migraine relief

Gao,

Yan,

Wang-Sattler

et al. 2023

Preprint

View full text Add to dashboard Cite

Acupuncture is used worldwide to treat migraine, but its scientific mechanism remains unclear. Here, we report a 1H NMR metabolomics study involving 40 migraine patients and 10 healthy people randomly receiving acupuncture or sham acupuncture, followed by machine learning techniques and functional analysis. We found that acupuncture at acupoints particularly enhanced anaerobic glycolysis and modified mitochondrial function by adjusting the levels of plasma pyruvic acid (P = 0.012), lactic acid (P = 0.031) and citrate (P = 0.00079) at a Bonferroni-corrected level of significance compared to the pre-treatment level of these three metabolites in migraine patients. Therefore, acupuncture supplies energy to migraine patients and relieves migraine attacks. In contrast, we observed that sham acupuncture may partially supply energy to migraine patients through lipid metabolism by changing the levels of plasma lipid (P = 0.0012), glycerine (P = 0.021), and pyruvic acid (P = 0.047) at a Bonferroni-corrected level of significance. The functional network analysis further indicates this different way of supplying energy contributes to the different effects of acupuncture and sham acupuncture. Our findings reveal novel metabolic evidence for the specific effect of acupuncture in relation to sham acupuncture. This metabolic evidence could enlighten a brand new direction into acupuncture analgesia mechanism, which in turn would pose fresh challenges for future acupuncture research.

show abstract

Metabolic profile changes in serum of migraine patients detected using 1H-NMR spectroscopy

Cited by 8 publications

References 78 publications

Migraine genetics: Status and road forward

Migraine genetics: Status and road forward

Imaging Correlates between Headache and Breast Cancer: An [18F]FDG PET Study

Metabolomics reveals reasons for the efficacy of acupuncture in migraine patients: The role of anaerobic glycolysis and mitochondrial citrate in migraine relief

Contact Info

Product

Resources

About