Metabolic Profile Characterization of Different Thyroid Nodules Using FTIR Spectroscopy: A Review

Neto, Vanessa; Esteves-Ferreira, Sara; Inácio, Isabel; Alves, Márcia; Dantas, Rosa; Almeida, Idália; Guimarães, Joana; Azevedo, Teresa; Nunes, Alexandra

doi:10.3390/metabo12010053

Cited by 12 publications

(3 citation statements)

References 84 publications

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“…Methods for metabolome interrogation include Fourier transform-infrared (FT-IR) spectroscopy ( 205 ), Raman spectroscopy ( 206 ), NMR spectroscopy ( 18 , 207 ), MS-based approaches such as MS ( 20 ), MS/MS ( 208 ), liquid chromatography (LC)-MS ( 209 ), gas chromatography (GC)-MS ( 210 , 211 ), as well as others.…”

Section: Technology-based Omicsmentioning

confidence: 99%

Advances and Trends in Omics Technology Development

2022

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The human history has witnessed the rapid development of technologies such as high-throughput sequencing and mass spectrometry that led to the concept of “omics” and methodological advancement in systematically interrogating a cellular system. Yet, the ever-growing types of molecules and regulatory mechanisms being discovered have been persistently transforming our understandings on the cellular machinery. This renders cell omics seemingly, like the universe, expand with no limit and our goal toward the complete harness of the cellular system merely impossible. Therefore, it is imperative to review what has been done and is being done to predict what can be done toward the translation of omics information to disease control with minimal cell perturbation. With a focus on the “four big omics,” i.e., genomics, transcriptomics, proteomics, metabolomics, we delineate hierarchies of these omics together with their epiomics and interactomics, and review technologies developed for interrogation. We predict, among others, redoxomics as an emerging omics layer that views cell decision toward the physiological or pathological state as a fine-tuned redox balance.

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Section: Technology-based Omicsmentioning

confidence: 99%

Advances and Trends in Omics Technology Development

2022

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“…RS is sensitive for lipids, amino acids, and nucleic acids and, additionally, for disulphides and cytochromes. FTIR is sensitive to protein and phosphate content and their structures, and thyroid FTIR investigation has proven to be useful in the diagnosis of TNs [17]. RS spectra are not sensitive to water content, as FTIR is, and have been used for both in vitro, for cytological and tissue samples, and in vivo analyses (fiber-optic RS performed during surgery).…”

Section: Raman Spectroscopymentioning

confidence: 99%

Raman Spectroscopy as a Potential Adjunct of Thyroid Nodule Evaluation: A Systematic Review

Kujdowicz,

Januś,

Taczanowska-Niemczuk

et al. 2023

IJMS

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The incidence of thyroid nodules (TNs) is estimated at 36.5% and 23% in females and males, respectively. A single thyroid nodule is usually detected during ultrasound assessment in patients with symptoms of thyroid dysfunction or neck mass. TNs are classified as benign tumours (non-malignant hyperplasia), benign neoplasms (e.g., adenoma, a non-invasive follicular tumour with papillary nuclear features) or malignant carcinomas (follicular cell-derived or C-cell derived). The differential diagnosis is based on fine-needle aspiration biopsies and cytological assessment (which is burdened with the bias of subjectivity). Raman spectroscopy (RS) is a laser-based, semiquantitative technique which shows for oscillations of many chemical groups in one label-free measurement. RS, through the assessment of chemical content, gives insight into tissue state which, in turn, allows for the differentiation of disease on the basis of spectral characteristics. The purpose of this study was to report if RS could be useful in the differential diagnosis of TN. The Web of Science, PubMed, and Scopus were searched from the beginning of the databases up to the end of June 2023. Two investigators independently screened key data using the terms “Raman spectroscopy” and “thyroid”. From the 4046 records found initially, we identified 19 studies addressing the differential diagnosis of TNs applying the RS technique. The lasers used included 532, 633, 785, 830, and 1064 nm lines. The thyroid RS investigations were performed at the cellular and/or tissue level, as well as in serum samples. The accuracy of papillary thyroid carcinoma detection is approx. 90%. Furthermore, medullary, and follicular thyroid carcinoma can be detected with up to 100% accuracy. These results might be biased with low numbers of cases in some research and overfitting of models as well as the reference method. The main biochemical changes one can observe in malignancies are as follows: increase of protein, amino acids (like phenylalanine, tyrosine, and tryptophan), and nucleic acid content in comparison with non-malignant TNs. Herein, we present a review of the literature on the application of RS in the differential diagnosis of TNs. This technique seems to have powerful application potential in thyroid tumour diagnosis.

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“…Hyperspectral Fourier transform imaging spectroscopy (FTIS) enables the simultaneous acquisition of two-dimensional spatial information and one-dimensional spectral information, and has proven to be a critical tool in numerous scientific and industrial fields, including biomedicine [1][2][3], agriculture [4,5], remote sensing [6], and others. In recent years, several types of Fourier transform imaging spectroscopies (FTISs) have been developed, including interferometers based on Michelson interferometers [7][8][9][10], Sagnac interferometers [11][12][13][14][15][16][17], Mach-Zehnder interferometers [18][19][20], and Fabry-Perot interferometers [21,22].…”

Section: Introductionmentioning

confidence: 99%

Hyperspectral Channel-Modulated Static Birefringent Fourier Transform Imaging Spectropolarimeter with Zoomable Spectral Resolution

Zhang,

Zhu,

Huang

et al. 2023

Photonics

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A novel channel-modulated static birefringent Fourier transform imaging spectropolarimeter (CSBFTIS) is introduced, which is based on a double Wollaston prism (DWP). With an adjustable air gap (AG), the spectral resolution can be adjusted by changing the AG. The CSBFTIS combines the channel-modulated imaging spectropolarimeter and the slit-free static birefringent Fourier transform imaging spectrometer technology with adjustable spectral resolution. The device is compact and robust, with a wide spectral range and a large luminous flux. Compared with various previous spectropolarimeters, it can greatly reduce the size of the spectral image data to adapt to different application requirements. A prototype is built, and simulation and experiments are carried out, and the results prove the effectiveness of the method.

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Metabolic Profile Characterization of Different Thyroid Nodules Using FTIR Spectroscopy: A Review

Cited by 12 publications

References 84 publications

Advances and Trends in Omics Technology Development

Advances and Trends in Omics Technology Development

Raman Spectroscopy as a Potential Adjunct of Thyroid Nodule Evaluation: A Systematic Review

Hyperspectral Channel-Modulated Static Birefringent Fourier Transform Imaging Spectropolarimeter with Zoomable Spectral Resolution

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