Metabolic profile of olive leaves of different cultivars and collection times

Lorini, Alexandre; Aranha, Bianca Camargo; Antunes, Bruna da Fonseca; Otero, Deborah Murowaniecki; Jacques, Andressa Carolina; Zambiazi, Rui Carlos

doi:10.1016/j.foodchem.2020.128758

Cited by 38 publications

(44 citation statements)

References 35 publications

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“…The varieties that showed the highest oleuropein content in the olive leaf coincide with the study carried out by Lorini et al (2021) [10] of Arbequina, Manzanilla and Picual cultivars, where the highest oleuropein content in olive leaf throughout the four seasons (winter, spring, summer and autumn) was observed in the Picual variety, followed very closely by Manzanilla. Similar trends to other studies were also observed during the different seasons, in winter a decrease in oleuropein content of Picual and Cornicabra was observed, which was similar to that observed by Romero et al (2017) [11] in olive leaves from Picual trees in the south of Spain during the 2012/2013 season, where the oleuropein content decreased from 72.12 mg/g in November to 54.02 mg/g in January.…”

Section: Discussionsupporting

confidence: 80%

Determination of the Variability of Bioactive Compounds and Minerals in Olive Leaf along an Agronomic Cycle

et al. 2021

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Olive leaves are still considered waste in the oil industry; however, the leaves have a content of oleuropein and other bioactive compounds that gives them great potential to be transformed into by-products. The most appropriate moment along an agronomic cycle (November 2019 to October 2020) has been evaluated to take advantage of this potential of the olive leaves varieties of Picual, Cornicabra and Manzanilla. In addition, factors that affect the content of phenolic compounds such as absolute maximum and minimum temperatures, relative humidity, sunshine hours, rainfall, differential of temperatures and mineral nutrition have been studied. The results show that the pruning season was the best time to take advantage of the olive leaf due to its high oleuropein content, especially in Picual and Manzanilla. The variety was the factor that most affected all the phenolic compounds studied, while the absolute minimum temperature factor notably affected verbascoside. Particular mineral nutrients, such as Mg and Fe, turned out to be most useful for differentiating locations. The content of verbascoside and hydroxytyrosol was also affected by agronomic conditions (location/conventional or ecological).

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Section: Discussionsupporting

confidence: 80%

Determination of the Variability of Bioactive Compounds and Minerals in Olive Leaf along an Agronomic Cycle

et al. 2021

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“…The production of phytochemicals in the plant metabolism is a dynamic process [47,48] and depends on several factors, including the vegetative period, collection year and time, and geographic locations [49][50][51][52]. Several studies have shown that both total and individual phenolic compounds have even changed in the same species due to geographical factors [37,39,53].…”

Section: Quantification Of Phytochemicalsmentioning

confidence: 99%

Shedding Light into the Connection between Chemical Components and Biological Effects of Extracts from Epilobium hirsutum: Is It a Potent Source of Bioactive Agents from Natural Treasure?

Zengin

Mahomoodally

et al. 2021

Antioxidants

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Epilobium hirsutum is extensively used as a traditional remedy in folk medicine, especially against prostate inflammation. Therefore, we evaluated the chemical profiles and biopharmaceutical potentials of different extracts of E. hirsutum aerial parts and roots. Metabolomic, antioxidant, and enzyme inhibitory profiles were investigated. Human prostate cancer PC3 cells were exposed to the extracts to evaluate antiproliferative effects. Gene expression and bioinformatics analyses were performed to investigate anti-inflammatory mechanisms. Oenothein B and myricetin were prominent compounds in the extracts. In scavenging/reducing assays, the methanol, infusion, and methanol/water extracts exhibited similar activities. We also observed the reduction of PC3 viability occurring following exposure to methanol and methanol/water extracts. According to bioinformatics analysis, myricetin was predicted to interact with COX-2 and TNFα. The interaction between TNFα and oxo-dihydroxy-octadecenoic acid was predicted as well. Intriguingly, the gene expression of COX-2 and TNFα was reduced in PC3 cells after exposure to methanol and methanol/water extracts. These effects were paralleled by the decreased gene expression of IL-8 and NFkB and the inhibition of PGE2 release. Therefore, the present findings suggest the potential use of E. hirsutum for the management of the burden of inflammation and oxidative stress occurring in lower urinary tract diseases, including prostatitis.

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“…OLs are a rich source of valuable polyphenols, whereas olive fruits are good sources of oleuropeosides, flavonols, and flavones [ 29 , 30 , 31 , 32 ]. Numerous studies have established that the bioactive components in OLs possess beneficial properties, including antioxidant, antimicrobial, and antitumor characteristics [ 28 , 33 , 34 , 35 , 36 , 37 ]. Accordingly, OLs are a natural, inexpensive, and readily available source of phenolic compounds [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Efficacy of Olive Leaf (Olea europaea L.) Extracts in the Treatment of Colorectal Cancer and Prostate Cancer Using In Vitro Cell Models

Albogami

Hassan

2021

Molecules

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Cancer is one of the most serious public health issues worldwide, ranking second only to cardiovascular diseases as a cause of death. Numerous plant extracts have extraordinary health benefits and have been used for centuries to treat a variety of ailments with few side effects. Olive leaves have a long history of medicinal and therapeutic use. In this study, the anti-cancer properties of an olive leaf extract were investigated in vitro using colorectal and prostate cancer cell lines (HT29 and PC3, respectively). A high-performance liquid chromatography analysis showed that the olive leaf extract contained a high chlorogenic acid content. Accordingly, chlorogenic acid may be related to the observed effects of the aqueous extract on cancer cells, including increased inhibition of cancer cell growth, migration, DNA fragmentation, cell cycle arrest at the S phase, reactive oxygen species (ROS) production, and altered gene expression. The effects of the extracts were greater in HT29 than in PC3 cells. These results suggest that chlorogenic acid, the main constituent in the olive extract, is a promising new anti-cancer agent. Further analyses should focus on its in vivo effects on colorectal tumor models, both alone and in combination with established agents.

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Metabolic profile of olive leaves of different cultivars and collection times

Cited by 38 publications

References 35 publications

Determination of the Variability of Bioactive Compounds and Minerals in Olive Leaf along an Agronomic Cycle

Determination of the Variability of Bioactive Compounds and Minerals in Olive Leaf along an Agronomic Cycle

Shedding Light into the Connection between Chemical Components and Biological Effects of Extracts from Epilobium hirsutum: Is It a Potent Source of Bioactive Agents from Natural Treasure?

Assessment of the Efficacy of Olive Leaf (Olea europaea L.) Extracts in the Treatment of Colorectal Cancer and Prostate Cancer Using In Vitro Cell Models

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