Metabolic profile of oxidative stress and trace elements in febrile seizures among children

El-Masry, Hosny M. A.; Sadek, Abdelrahim Abdrabou; Hassan, Mohammed H.; Ameen, Hesham H; Ahmed, Hosny A

doi:10.1007/s11011-018-0258-7

Cited by 22 publications

(15 citation statements)

References 26 publications

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“…In our study, epileptic patients with past history of febrile seizures showed significant decrease in zinc serum level in comparison to patients without history of febrile seizures. This agreed with previous studies which revealed low zinc serum level in children with febrile seizures in comparison with controls [37][38][39][40] and in comparison with children who had acute febrile illness without febrile seizures [41]. Several studies support the idea that low zinc levels increase seizure susceptibility.…”

Section: Discussionsupporting

confidence: 92%

Serum zinc and copper levels in a sample of Egyptian epileptic children

Eissa

Abdulghani

Nada

et al. 2020

Egypt J Neurol Psychiatry Neurosurg

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Background: Epilepsy is among the most common disabling neurological disorders among children. Altered serum levels of zinc and copper may facilitate seizure occurrence and repetition, and antiepileptic drugs may disturb their serum levels affecting disease control and outcome. Objective: To investigate the association between serum levels of zinc and copper and epilepsy and antiepileptic treatment in a group of Egyptian epileptic children. Methods: Case-control study on 100 epileptic patients, aged from 2 to 16 years, from neurology outpatient clinic and 50 apparently healthy children with matched age and sex. Venous samples were withdrawn from patients and controls then serum levels of zinc and copper were measured with graphite furnace atomic absorption spectrometer-A Analyst 800. Results: Serum zinc level of patients' group was significantly lower than that of controls with a mean of 59.1 μ/dL ± 22.7 and 85 μ/dL ± 22.2, respectively (P < 0.01). Serum zinc level of patients with history of febrile seizures was significantly decreased compared to patients without history of febrile seizures with a mean of 41.5 μ/dL ± 20.1 and 67.9 μ/dL ± 19.3, respectively (P < 0.01). Patient on carbamazepine intake showed significantly lower zinc serum level than patients without carbamazepine intake, with a mean of 49.0 μ/dL ± 17 and 61.8 μ/dL ± 23.4, respectively (P < 0.01). A significant negative correlation was noted between the duration of illness of epilepsy and the mean copper serum level (P < 0.05). Conclusion: Zinc and copper altered homeostasis have mounting evidence about their role in the pathogenesis of epilepsy. Designing treatment plans that selectively restore zinc and copper normal levels may be a beneficial strategy in the future.

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Section: Discussionsupporting

confidence: 92%

Serum zinc and copper levels in a sample of Egyptian epileptic children

Eissa

Abdulghani

Nada

et al. 2020

Egypt J Neurol Psychiatry Neurosurg

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“…Nonetheless, the hemoglobin and hematocrit levels of the group with recurrent FS was statistically meaningfully lower than rst time FS patients group. Even though there is no linkage found in literature about serum zinc levels and recurrence of FS [29,59], in our study, serum zinc levels of recurrent FS group was statistically signi cantly lower compared to rst time FS patient group. Average serum zinc level was below normal for both groups.…”

Section: Discussioncontrasting

confidence: 79%

The Relation Between Febrile Seizure and Serum Iron and Zinc Levels in Children

Bulut¹,

Gayret²,

Erol³

et al. 2022

Preprint

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Purpose: Febrile seizures (FS) are the most commonly seen seizure type in children and its etiology is not fully understood. It is seen in 2-4% of all children. The most common factors contributing the etiopathogenesis of FS are fever, genetic predisposition and age. Other triggering factors include deficiency of iron, zinc and immunoglobulins as well as cytokine and interferon mechanisms. Methods: This prospective and sectional study includes children between the ages 5 months to 5 years, who came to the outpatient pediatric clinic of Health Sciences University Bagcilar Research and Education Hospital between August 2020 and May 2021. The patient group includes 53 patients who came to the emergency service with febrile seizures and came for a follow-up within the following month and the control group includes 53 healthy children who came for a routine checkup with no prior history of seizures or other illnesses. Results: The age of first time FS ranged from 7 months to 60 months with an average age of 19.6 months. 15.1% of patients had a first degree relative with a history of FS and 7.5% of patients had a family member with a history of epilepsy. Serum iron and serum zinc levels were statistically meaningfully lower in the FS group compared to the control group. (p:0.000; p:0.000; p<0.05 respectively)Conclusion: The occurrence of febrile seizures is closely related to serum iron and zinc levels. We can say that FS is triggered once these parameters are below a threshold.

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“…Disulfide (µmol / l) / alb (g / l). Oxidative stress index = total oxidant status / total antioxidant status) [19][20][21][22][23][24][25][26][27]. The results of hemogram and Vitamin B12, 25 OH D levels were retrospectively taken from their files.…”

Section: Laboratory Analysismentioning

confidence: 99%

Thiol Disulfide Balance Oxidative Stress and Paraoxonase 1 Activities in Children and Adolescents Aged 6-16 Years with Specific Learning Disorders

Savaş¹,

Sayar

Kara³

2021

ELECTRON J GEN MED

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Specific learning disorders (SLD) are some of the most common neurodevelopmental disorders. The aim of this study is to determine the potential relationship between children with SLD and zinc, copper, paraoxonase 1 (PON1), arylesterase (ARY), ischemia-modified albumin, thiol balance, oxidative stress index, total antioxidant status, total oxidant status, and routine biochemical parameters.Methods: All participants were assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children. Total oxidant status, total antioxidant status, thiol balance, ischemia modified albumin, paraoxonase 1 activity, arylesterase activity, zinc and copper levels were measured by the spectrophotometric methods.Results: Compared to the control, the SLD group had statistically significantly lower values for PON1 antioxidant enzyme activity (p=.045), ARY antioxidant enzyme activity (p<.001), 25 OH Vitamin D (p=.005), reduced thiol ratio (p=.028), thiol oxidation reduction ratio (p=.01), native thiols (p=.024) and significantly higher values for total oxidant status (p=.017), oxidized thiol ratio (p=.028). Conclusion:The relationship between oxidative stress and SLD diagnosis in our results will be very important if it is supported by further new studies. In this case, evaluation of vitamin D, oxidative stress, antioxidant status and thiol balance may come to the agenda in the diagnosis and treatment of SLD.

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Metabolic profile of oxidative stress and trace elements in febrile seizures among children

Cited by 22 publications

References 26 publications

Serum zinc and copper levels in a sample of Egyptian epileptic children

Serum zinc and copper levels in a sample of Egyptian epileptic children

The Relation Between Febrile Seizure and Serum Iron and Zinc Levels in Children

Thiol Disulfide Balance Oxidative Stress and Paraoxonase 1 Activities in Children and Adolescents Aged 6-16 Years with Specific Learning Disorders

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