Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer

Nava, Gerardo M.; Madrigal‐Perez, Luis Alberto

doi:10.1080/14737159.2022.2065196

Cited by 20 publications

(14 citation statements)

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“…A state of glucose depletion causes a metabolic shift from glycolysis to oxidative phosphorylation, as a compensatory strategy for metabolic needs [ 24 , 37 ], as well as an increase in mitochondrial mass [ 25 ]. Given that the combined treatment mimicked a condition of glucose deprivation, we performed a mitochondrial mass analysis in both B16-F10 and Mel16.…”

Section: Resultsmentioning

confidence: 99%

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The αMSH-Dependent PI3K Pathway Supports Energy Metabolism, via Glucose Uptake, in Melanoma Cells

Cardinali

Kovacs

Mosca

et al. 2023

Cells

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Stimulation of melanocytes and murine melanoma cells with αMSH plus the PI3K inhibitor LY294002 resulted in ROS increase, oxidative DNA damage, and pigment retention. We performed cellular and molecular biology assays (Western blot, FACS, immunofluorescence analysis, scratch assay) on murine and human melanoma cells. Treatment with αMSH plus LY294002 altered cortical actin architecture. Given that cytoskeleton integrity requires energy, we next evaluated ATP levels and we observed a drop in ATP after exposure to αMSH plus LY294002. To evaluate if the αMSH-activated PI3K pathway could modulate energy metabolism, we focused on glucose uptake by analyzing the expression of the Glut-1 glucose translocator. Compared with cells treated with αMSH alone, those exposed to combined treatment showed a reduction of Glut-1 on the plasma membrane. This metabolic alteration was associated with changes in mitochondrial mass. A significant decrease of the cell migratory potential was also observed. We demonstrated that the αMSH-dependent PI3K pathway acts as a regulator of energy metabolism via glucose uptake, influencing the actin cytoskeleton, which is involved in melanosome release and cell motility. Hence, these results could constitute the basis for innovative therapeutical strategies.

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Section: Resultsmentioning

confidence: 99%

“…In cancer cells, including melanoma, glucose is mainly metabolized by aerobic glycolysis (the Warburg effect) and efficiently produces ATP and lactate as by-products. The Warburg effect is associated with increased rates of cell proliferation [ 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

The αMSH-Dependent PI3K Pathway Supports Energy Metabolism, via Glucose Uptake, in Melanoma Cells

Cardinali

Kovacs

Mosca

et al. 2023

Cells

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“…[10][11][12] On the other hand, Warburg effect is characterized by hyperlactacemia. [1,13] This phenomenon has been described in a number of different solid tumors, such as lung cancer,[2, 14] colorectal cancer,[3, 15, 16] cervical cancer, Page 4/8 intrinsic pontine glioma, gastric cancer [4], among others. The glycolytic phenotype of cancer cell leads to excessive amounts of lactic acid production, which acts as an energy source for interorganic-carbon supply of circulating carbohydrates and a carcinogenic signal, heightening the interaction and interference between tumor cells and adjacent cells, creating favorable conditions for tumor-stroma interaction.…”

Section: Discussionmentioning

confidence: 99%

“…This phenomenon leads to increased glucose consumption and excess lactic level accumulation. [1] Warburg effect has been widely investigated in some solid tumor that closely related to tumor proliferation, anti-apoptosis, chemoresistance, metastasis and poor clinical outcomes, [2][3][4] however, it had been rarely reported in diffuse large B-cell lymphoma (DLBCL) and hemophagocytic lymphohistiocytosis (HLH). [5][6][7] In addition, treatment options for hyperlactacemia are limited, and it also associated with high mortality.…”

Section: Introductionmentioning

confidence: 99%

Warburg effect secondary to diffuse large B‑cell lymphoma-associated hemophagocytic lymphohistiocytosis: a case report

Zhou

Wang

Zhu

et al. 2022

Preprint

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Background: The increase in glucose consumption during aerobic glycolysis of cancer cells, known as the Warburg effect, is associated with dismal prognosis. Warburg effect secondary to diffuse large B‑cell lymphoma (DLBCL) is rare and there is no specific treatment regimen. Case presentation: We here described a case of patient who presented with hemophagocytic lymphohistiocytosis and developed hyperlactacemia inducing by Warburg effect, then he was successfully treated by continuous renal replacement therapy (CRRT) and diagnostic chemotherapy. Eventually, he was diagnosed as DLBCL. Conclusion: Existing evidence shows that Warburg effect can be secondary to diffuse large B-cell lymphoma, CRRT combined with diagnostic chemotherapy was effective in this case. Additive attention should be paid to this phenomenon and effective strategy remains to be explored.

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“…In addition, we believe that it would be worthwhile to investigate less invasive techniques, such as plasma metabolites and proteins derived from the Warburg-effect (e.g. glucose, lactate, GLUT1) or fluorodeoxyglucose (FDG)-uptake by primary tumors, as those may be used for both prognosis and diagnosis of CRC 142 .…”

Section: Recommendations For Future Researchmentioning

confidence: 99%

Cancer cell metabolism and colorectal cancer survival

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Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer

Cited by 20 publications

References 100 publications

The αMSH-Dependent PI3K Pathway Supports Energy Metabolism, via Glucose Uptake, in Melanoma Cells

The αMSH-Dependent PI3K Pathway Supports Energy Metabolism, via Glucose Uptake, in Melanoma Cells

Warburg effect secondary to diffuse large B‑cell lymphoma-associated hemophagocytic lymphohistiocytosis: a case report

Cancer cell metabolism and colorectal cancer survival

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