Metabolic profiles and treatment gaps in young-onset type 2 diabetes in Asia (the JADE programme): a cross-sectional study of a prospective cohort

Yeung, Roseanne O.; Zhang, Yuying; Luk, Andrea; Yang, Wenying; Sobrepeña, Leorino; Yoon, Kun‐Ho; Aravind, S.R.; Sheu, Wayne Huey Herng; Nguyen, Thy Khue; Ozaki, Risa; Deerochanawong, Chaicharn; Tsang, Chiu Chi; Chan, Wing-Bun; Hong, Eun Gyoung; Quan, T Phuong; Cheung, Y. Whitney; Brown, Nicola; Goh, Su-Yen; Ronald, C.; Mukhopadhyay, Monojitketan; Ojha, Arvind Kumar; Chakraborty, Shaibal; Kong, Alice Pik Shan; Lau, Winnie W. Y.; Jia, Weiping; Li, Wenhui; X, Guo; Bian, Rongwen; Weng, Jianping; Ji, Linong; Rosa, Mercedes Reyes-dela; Toledo, Ronaldo M; Himathongkam, Thep; Yoo, Soon‐Jib; Chow, Chun Chung; Ho, Larry L.T.; Chuang, Lee‐Ming; Tutino, G. E.; Tong, Peter C.Y.; So, Wing‐Yee; Wolthers, Troels; Ko, G. T. C.; Lyubomirsky, Greg; Chan, Juliana C.N.

doi:10.1016/s2213-8587(14)70137-8

Cited by 236 publications

(269 citation statements)

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“…Therefore, we believe that the more likely explanation is that young-onset type 2 diabetes represents a more severe form of diabetes. Our data support recently published studies suggesting that young-onset type 2 diabetes is the more lethal phenotype of diabetes and is associated with a greater mortality, more diabetes complications, unfavorable CVD risk factors, and greater difficulty in achieving glycemic control, even compared with type 1 diabetes (33)(34)(35)(36). Given the increasing incidence of young-onset type 2 diabetes and its severity, there is an urgent need for diabetes prevention efforts to be targeted toward youth.…”

Section: Comparison With the Literaturesupporting

confidence: 91%

Age-Specific Trends From 2000–2011 in All-Cause and Cause-Specific Mortality in Type 1 and Type 2 Diabetes: A Cohort Study of More Than One Million People

et al. 2016

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OBJECTIVETo analyze changes by age-group in all-cause and cause-specific mortality rates from 2000-2011 in people with diabetes. RESEARCH DESIGN AND METHODSA total of 1,189,079 (7.3% with type 1 diabetes) Australians with diabetes registered on the National Diabetes Service Scheme between 2000 and 2011 were linked to the National Death Index. Mortality rates in the total population were age standardized to the 2001 Australian population. Mortality rates were calculated for the following age-groups: 0 to <40 years, ‡ 40 to <60 years, and ‡60 to £85 years. Annual mortality rates were fitted using a Poisson regression model including calendar year as a covariate and age and sex where appropriate, with P trend reported. RESULTSFor type 1 diabetes, all-cause, cardiovascular disease (CVD), and diabetes agestandardized mortality rates (ASMRs) decreased each year by 0.61, 0.35, and 0.14 per 1,000 person-years (PY), respectively, between 2000 and 2011, P trend < 0.05, while cancer mortality remained unchanged. By age, significant decreases in allcause, CVD, and diabetes mortality rates were observed in all age-groups, excluding diabetes mortality in age-group 0-40 years. For type 2 diabetes, all-cause, CVD, and diabetes ASMRs decreased per year by 0.18, 0.15, and 0.03 per 1,000 PY, respectively, P trend < 0.001, while cancer remained unchanged. By age, these decreases were observed in all age-groups, excluding 0-40 years, where significant increases in all-cause and cancer mortality were noted and no change was seen for CVD and diabetes mortality. CONCLUSIONSAll-cause, CVD, and diabetes ASMRs in type 1 and type 2 diabetes decreased between 2000 and 2011, while cancer ASMRs remained unchanged. However, younger populations are not benefiting from the same improvements as older populations. In addition, the absence of a decline in cancer mortality warrants urgent attention.

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Section: Comparison With the Literaturesupporting

confidence: 91%

Age-Specific Trends From 2000–2011 in All-Cause and Cause-Specific Mortality in Type 1 and Type 2 Diabetes: A Cohort Study of More Than One Million People

et al. 2016

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“…So the young patients showed a lifestyle of a relatively high‐energy intake and less physical activity in this province. In a study of metabolic control or the burden of associated complications in adult diabetes in Asia (the Joint Asia Diabetes Evaluation cohort), Yeung et al 32. showed that approximately 18% of the diabetes were young‐onset (diagnosed before 40 years‐of‐age).…”

Section: Discussionmentioning

confidence: 99%

Dietary and physical activity of adult patients with type 2 diabetes in Zhejiang province of eastern China: Data from a cross‐sectional study

Pan

Ming-xia

et al. 2016

J of Diabetes Invest

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Aims/IntroductionLifestyle management helps improve the clinical outcome of patients with type 2 diabetes. The present study aimed to obtain lifestyle data on the dietary and physical activity of adult type 2 diabetes patients in Zhejiang province of eastern China for better patient education and improvement of clinical management.Materials and MethodsA cross‐sectional survey of 607 adult type 2 diabetes patients was carried out in 12 hospitals within eight cities of Zhejiang province. Data were collected for sex, age, basic physical measurement (blood pressure, height, weight, waist circumference and hip circumference), dietary favor and habit (vegetarian diets vs meat diets, preference of salty or light flavors), detailed dietary intake (24‐h recall method), as well as the weekly physical activity.ResultsThe mean age of the patients in the analysis was 56.39 ± 12.29 years, and 38.71% of the patients had higher levels of body mass index than recommended. The average daily total energy intake was 1887.71 ± 575.10 kcal. The percentage of calories from carbohydrate, protein and fat were 61.36 ± 11.59%, 13.29 ± 3.37% and 25.35 ± 11.16%, respectively. For physical activity, the patients generally spent most of their daily time sitting and sleeping, and the time for moderate vigorous activity was limited.ConclusionsAdult patients with type 2 diabetes in Zhejiang province have a relatively high carbohydrate and low protein diet, with very limited physical activity. Patient education to achieve a better lifestyle intervention needs to improve in this region.

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“…In the Joint Asia Diabetes Evaluation (JADE) program, among 41,029 patients recruited from across nine countries/regions in Asia, 18% had onset of T2DM below the age of 40 (97), had longer disease duration, and had higher rates of retinopathy and end-stage renal disease than those with onset of diabetes after the age of 40 (97). In the Hong Kong Diabetes Registry, patients with young-onset diabetes had higher risks of incident cardiovascular and renal complications at any age, driven by the longer disease duration (98).…”

Section: Pattern Of Diabetes Complications In Asia and Pacific Communmentioning

confidence: 99%

Diabetes in Asia and the Pacific: Implications for the Global Epidemic

et al. 2016

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The last three decades have witnessed an epidemic rise in the number of people with diabetes, especially type 2 diabetes, and particularly in developing countries, where more than 80% of the people with diabetes live. The rise of type 2 diabetes in South Asia is estimated to be more than 150% between 2000 and 2035. Although aging, urbanization, and associated lifestyle changes are the major determinants for the rapid increase, an adverse intrauterine environment and the resulting epigenetic changes could also contribute in many developing countries. The International Diabetes Federation estimated that there were 382 million people with diabetes in 2013, a number surpassing its earlier predictions. More than 60% of the people with diabetes live in Asia, with almost one-half in China and India combined. The Western Pacific, the world’s most populous region, has more than 138.2 million people with diabetes, and the number may rise to 201.8 million by 2035. The scenario poses huge social and economic problems to most nations in the region and could impede national and, indeed, global development. More action is required to understand the drivers of the epidemic to provide a rationale for prevention strategies to address the rising global public health “tsunami.” Unless drastic steps are taken through national prevention programs to curb the escalating trends in all of the countries, the social, economic, and health care challenges are likely to be insurmountable.

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Metabolic profiles and treatment gaps in young-onset type 2 diabetes in Asia (the JADE programme): a cross-sectional study of a prospective cohort

Cited by 236 publications

References 31 publications

Age-Specific Trends From 2000–2011 in All-Cause and Cause-Specific Mortality in Type 1 and Type 2 Diabetes: A Cohort Study of More Than One Million People

Age-Specific Trends From 2000–2011 in All-Cause and Cause-Specific Mortality in Type 1 and Type 2 Diabetes: A Cohort Study of More Than One Million People

Dietary and physical activity of adult patients with type 2 diabetes in Zhejiang province of eastern China: Data from a cross‐sectional study

Diabetes in Asia and the Pacific: Implications for the Global Epidemic

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