Metabolic Profiles in Obese Children and Adolescents with Insulin Resistance

Kostovski, Marko; Simeonovski, Viktor; Mironska, Kristina; Tasić, Velibor; Gucev, Zoran

doi:10.3889/oamjms.2018.097

Cited by 31 publications

(28 citation statements)

References 59 publications

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“…25 Kostovski et al has concluded that insulin resistant obese children and adolescents tend to have a worse metabolic profile in comparison to individuals without insulin resistance. 26 Above two studies support our finding.…”

Section: Discussionsupporting

confidence: 86%

Study of prevalence of metabolic syndrome in obese children in Konaseema region of India

Pratyush

Rao

2020

Int J Contemp Pediatr

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Background: The rising prevalence of overweight and obesity is associated with development of growing number of early complications in children and adolescents among that type 2 diabetes mellitus and metabolic syndrome (MS) is common. Present study has been designed to identify the prevalence of MS in children with overweight risk, overweight or obesity and to compare anthropometric and biochemical parameters in patients with metabolic syndrome and without MS.Methods: This is a cross sectional descriptive study conducted in the department of paediatrics where 120 patients with obesity were enrolled for this study and various metabolic parameters were compared.Results: In our study the prevalence of metabolic syndrome was 30% among obese and overweight children. Fasting insulin (18.65±13.64 mg/dl versus 16.48±10.32 mg/dl) was significantly higher in patients with MS than without MS (p is less than 0.05). Homeostatic model assessment of insulin resistance (HOMA-IR) was 5.84±1.43 in MS group and 4.54±1.34 in without MS group. The p value was 0.00. The glycocylated haemoglobin was significantly higher in MS group than without MS group (5.84±0.78 versus 4.54±0.34).Conclusions: From our study we can conclude that metabolic syndrome is a common problem in children with overweight and obesity in our region. Insulin resistance and metabolic abnormality were more common in children with MS.

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Section: Discussionsupporting

confidence: 86%

Study of prevalence of metabolic syndrome in obese children in Konaseema region of India

Pratyush

Rao

2020

Int J Contemp Pediatr

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“…A similar result was found in a study in Jakarta (Pulungan et al, 2013). In contrast, A study by Kostovski in Macedonia showed that the percentage of female experienced insulin resistance was higher than the male with p = 0.009 (p <0.05) (Kostovski et al, 2018). The explanation to this finding was because 52.94% of the female were in adolescence while 68.89% the male was in the pre-adolescent age.…”

Section: Discussionsupporting

confidence: 83%

Relationship Between Vitamin D Deficiency And Insulin Resistance In Obese Children

Juliaty¹,

Gabrilasari²,

Daud³

et al. 2020

GJHS

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INTRODUCTION: Obesity represents the major risk factor for development of insulin resistance during childhood and adolescents. In obesity, adipose tissue release free fatty acids, various hormones, and cytokines, resulting in insulin resistance. This study aimed to establish the correlation between vitamin D deficiency and the incidence of insulin resistance in obese children. DESIGN AND METHOD: This analytical cross-sectional study was arranged from December 2019 - February 2020 included 96 students aged 11 - 17 years old from junior and senior high school who met the criteria for obesity in Makassar. The study subjects were parted into two groups, obese children with vitamin D deficiency (levels of 25-hydroxyvitamin D ≤ 20 ng/ml) and obese children without vitamin D deficiency group (levels of 25-hydroxyvitamin D > 20 ng/ml). Data were analyzed using univariate and bivariate analysis. RESULTS: The frequency of insulin resistance in obese children with vitamin D deficiency was 28 (54.9%), while obese children without vitamin D deficiency was 10 (22.2%). Based on statistical analysis, the frequency of the occurrence of insulin resistance in vitamin D deficiency obese children was higher than in obese children without vitamin D deficiency with OR = 4.261 (95% CI 1.744 – 10.411), p = 0.001. CONCLUSION: The risk of insulin resistance in obese children with vitamin D deficiency is 4.261 times higher than obese children without vitamin D deficiency.

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“…However, the effect of the mentioned factors on the preoperative serum glucose level is still in debate [ 9 ]. Age and body weight of children are considered important factors that influence serum glucose levels [ 10 ]. Children with lower body weight are more susceptible to hypoglycemia during fasting compared to children with higher body weight [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Preoperative Fasting Duration on Blood Glucose and Hemodynamics in Children

Hajian

Shabani

Khanlarzadeh

et al. 2020

Journal of Diabetes Research

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Background. Prolonged preoperative fasting is one of the concerns of pediatricians and anesthesiologists in pediatric surgery. The aim of this study was to assess the impact of preoperative fasting duration on blood glucose and hemodynamics in children. Methods. This cross-sectional study was conducted on 50 children who were between the ages of 3 and 12 years in Besat Hospital, Hamedan, Iran. The time of the last solid and liquid meal taken by child were recorded based on interview with the parents. The first blood glucose test was obtained in the operation room, and the second test was performed 20 minutes after induction of anesthesia by glucometer. Systolic blood pressure (SBP), mean arterial pressure (MAP), and heart rate (HR) were recorded before anesthesia induction and in five-minute intervals in the first 20 minutes of surgery. Results. The mean age of the children was 6.63 (SD 1.85) years. Mean blood glucose 20 minutes after surgery was 101.17 (SD 92) mg/dl, which was significantly higher than the baseline values (87.66 (SD 11.84) mg/dl) (P<0.001). The comparison of mean blood glucose level between groups of fasting with different duration for solids (<12 hours and >12 hours) and for liquids (<6 hours and >6 hours) revealed no significant difference in either groups (P>0.05). No significant correlation was observed between blood glucose level at the induction of anesthesia with weight and age (P>0.05). There was a significantly negative correlation between duration of fasting for liquids and SBP (P>0.05). Conclusion. Prolonged preoperative fasting cannot affect blood glucose in children; however, maybe it has impact on systolic blood pressure.

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Metabolic Profiles in Obese Children and Adolescents with Insulin Resistance

Cited by 31 publications

References 59 publications

Study of prevalence of metabolic syndrome in obese children in Konaseema region of India

Study of prevalence of metabolic syndrome in obese children in Konaseema region of India

Relationship Between Vitamin D Deficiency And Insulin Resistance In Obese Children

The Impact of Preoperative Fasting Duration on Blood Glucose and Hemodynamics in Children

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