2020
DOI: 10.21203/rs.3.rs-44974/v1
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Metabolic profiles of whole serum and serum-derived exosomes are different in head and neck cancer patients treated by radiotherapy

Abstract: Background Serum metabolome reflects a general patient's body response to both disease state (e.g., cancer) and implemented treatment (e.g., radiotherapy, RT). Though serum-derived exosomes are an emerging type of liquid biopsy, a metabolite content of these vesicles remains under-researched yet. In this pilot study, we aimed to compare metabolite profiles of the whole serum and serum-derived exosomes in the context of differences between cancer patients and healthy controls as well as patients’ response to R… Show more

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Cited by 14 publications
(3 citation statements)
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“…Moreover, if exosomes actually have any shuttling function for ( poly)phenolic compounds under ( patho) physiological conditions remains poorly elucidated so far. Nevertheless, in head and neck cancer patients' serum-derived EVs, particular small metabolites were found to be markedly downregulated compared to healthy controls, like citric acid and 4-hydroxybenzoic acid, 71 important metabolomic alterations in exosome cargo observed in pathological conditions. This observation highlights that small compounds, despite chemically different, can comprise valid exosome payloads in addition to proteins, nucleic acids or other metabolites like glucose, glutamate, etc.…”
Section: Reviewmentioning
confidence: 95%
“…Moreover, if exosomes actually have any shuttling function for ( poly)phenolic compounds under ( patho) physiological conditions remains poorly elucidated so far. Nevertheless, in head and neck cancer patients' serum-derived EVs, particular small metabolites were found to be markedly downregulated compared to healthy controls, like citric acid and 4-hydroxybenzoic acid, 71 important metabolomic alterations in exosome cargo observed in pathological conditions. This observation highlights that small compounds, despite chemically different, can comprise valid exosome payloads in addition to proteins, nucleic acids or other metabolites like glucose, glutamate, etc.…”
Section: Reviewmentioning
confidence: 95%
“…These cargoes are involved in pathways in the cancer microenvironment that regulate the aggressive phenotype of cancer (Table 2, Ref. [16,17,[87][88][89][90][91][92][93][94][95][96][97][98][99][100]). On the one hand, exosomes after radiotherapy suppress aggressive phenotypes of tumor cells, such as proliferation and migration; on the other hand, exosome-mediated signaling after irradiation promotes the aggressive phenotype of cancer cells, such as drug resistance and radiotherapy resistance, by establishing communication between tumor cells and their microenvironment.…”
Section: Alteration Of Exosomal Cargoes After Tumor Radiotherapymentioning
confidence: 99%
“…In the circulating exosomes of HNSCC patients treated with radiotherapy, 1-hexadecanol was increased, citric acid, 4hydroxybenzoic acid, and propylene glycol were significantly decreased, and glycerol and cholesterol showed a moderate reduction. These metabolite-related pathways include fatty acid oxidation and ketone body metabolism [99]. Twenty-four significantly altered metabolites appeared in the plasma EVs of mice receiving cranial irradiation.…”
Section: Othersmentioning
confidence: 99%