Metabolic profiling and in vitro-in vivo extrapolation of furathiocarb in mammalian hepatic microsomes

Abass, Khaled; Reponen, Petri; Alsanie, Walaa F.; Rautio, Arja; Pelkonen, Olavi

doi:10.1016/j.toxrep.2022.03.030

Cited by 1 publication

(1 citation statement)

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“…Utilizing liquid chromatography-mass spectrometry (LC-MS) analysis, a total of eight phase I metabolites were identified. Primary metabolic pathways observed included the oxidation of sulfur and the cleavage of the nitrogen-sulfur bond (N-S) in the parent compounds (Abass et al, 2009;Abass et al, 2014;Abass et al, 2022;Abass et al, 2023). The metabolism of carbamate pesticides to more potent metabolites through the carbofuran pathway is a prevalent feature across all species examined, although there were notable differences in amounts and ratios of the metabolic pathways involved.…”

Section: Metabolismmentioning

confidence: 99%

Metabolites in the regulatory risk assessment of pesticides in the EU

Pelkonen,

Abass,

Parra Morte

et al. 2023

Front. Toxicol.

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A large majority of chemicals is converted into metabolites through xenobiotic-metabolising enzymes. Metabolites may present a spectrum of characteristics varying from similar to vastly different compared with the parent compound in terms of both toxicokinetics and toxicodynamics. In the pesticide arena, the role of metabolism and metabolites is increasingly recognised as a significant factor particularly for the design and interpretation of mammalian toxicological studies and in the toxicity assessment of pesticide/metabolite-associated issues for hazard characterization and risk assessment purposes, including the role of metabolites as parts in various residues in ecotoxicological adversities. This is of particular relevance to pesticide metabolites that are unique to humans in comparison with metabolites found in in vitro or in vivo animal studies, but also to disproportionate metabolites (quantitative differences) between humans and mammalian species. Presence of unique or disproportionate metabolites may underlie potential toxicological concerns. This review aims to present the current state-of-the-art of comparative metabolism and metabolites in pesticide research for hazard and risk assessment, including One Health perspectives, and future research needs based on the experiences gained at the European Food Safety Authority.

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Section: Metabolismmentioning

confidence: 99%