2020
DOI: 10.1002/jssc.201901169
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Metabolic profiling comparison of isovitexin in normal and kidney stone model rats by ultra‐high‐performance liquid chromatography coupled to quadrupole time‐of‐flight mass spectrometry

Abstract: Isovitexin, a bioactive flavonoid constituent isolated from Desmodii Styracifolii, is considered an adjuvant for antiurolithiasis diseases. In this study, an ultra‐high‐performance liquid chromatography coupled with hybrid triple quadruple time‐of‐flight mass spectrometry method was developed to characterize and compare the metabolic profiling of isovitexin experimented on normal and kidney stone model rats. The comparative research indicated that 28 metabolites (18 phase I and 10 phase II) in normal rats and … Show more

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Cited by 5 publications
(2 citation statements)
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“…On the other hand, in the A. maculatum extract, the main fragment ions observed in the positive ions MS/MS spectrum were at m/z 415.1026 ([M+H-H 313.0706 ([ 0,2 X] + ) and 283.0603 ([ 0,1 X] + ). Despite these differences in the MS/MS spectra of isovitexin in two extracts examined, that could be attributed to the matrix effect, overall fragmentation patterns, together with presence of [M+H-4H 2 O] + ion at m/z 361,0703 and small intensity ion [Y 0 ] + at m/z 271,0603, as well absence of [ 0,3 X] + ion indicated 6-C-glycoside of apigenin [34][35][36][37].…”
Section: Structure Determination Of Biomarkers Of Adulterationmentioning
confidence: 94%
See 1 more Smart Citation
“…On the other hand, in the A. maculatum extract, the main fragment ions observed in the positive ions MS/MS spectrum were at m/z 415.1026 ([M+H-H 313.0706 ([ 0,2 X] + ) and 283.0603 ([ 0,1 X] + ). Despite these differences in the MS/MS spectra of isovitexin in two extracts examined, that could be attributed to the matrix effect, overall fragmentation patterns, together with presence of [M+H-4H 2 O] + ion at m/z 361,0703 and small intensity ion [Y 0 ] + at m/z 271,0603, as well absence of [ 0,3 X] + ion indicated 6-C-glycoside of apigenin [34][35][36][37].…”
Section: Structure Determination Of Biomarkers Of Adulterationmentioning
confidence: 94%
“…Where appropriate, biomarkers were also identified by their retention times, UV-vis and MS spectral data obtained from LC-DAD-MS (/MS) measurements. All spectral data were then compared with those from literature reports [30][31][32][33][34][35][36][37][38][39].…”
Section: Structure Determination Of Biomarkers Of Adulterationmentioning
confidence: 99%