Metabolic profiling of type 1 diabetes mellitus in children and adolescents: a case–control study

Bervoets, Liene; Massa, Guy; Guedens, Wanda; Louis, Evelyne; Noben, Jean-Paul; Adriaensens, Peter

doi:10.1186/s13098-017-0246-9

Cited by 41 publications

(32 citation statements)

References 24 publications

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“…L‐serine concentration has in several studies been found to be significantly altered in diabetes. A study of children with type 1 diabetes and non‐diabetic controls found that the concentration of L‐serine in plasma was decreased by 42% in patients . Similar studies of patients with type 2 diabetes have found reduced L‐serine concentration in blood .…”

mentioning

confidence: 84%

L‐serine: a neglected amino acid with a potential therapeutic role in diabetes

Holm

Buschard

2019

APMIS

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L‐serine is classified as a non‐essential amino acid; however, L‐serine is indispensable having a central role in a broad range of cellular processes. Growing evidence suggests a role for L‐serine in the development of diabetes mellitus and its related complications, with L‐serine being positively correlated to insulin secretion and sensitivity. L‐serine metabolism is altered in type 1, type 2, and gestational diabetes, and L‐serine supplementations improve glucose homeostasis and mitochondrial function, and reduce neuronal death. Additionally, L‐serine lowers the incidence of autoimmune diabetes in NOD mice. Dietary supplementations of L‐serine are generally regarded as safe (GRAS) by the FDA. Therefore, we believe that L‐serine should be considered as an emerging therapeutic option in diabetes, although work remains in order to fully understand the role of L‐serine in diabetes.

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confidence: 84%

L‐serine: a neglected amino acid with a potential therapeutic role in diabetes

Holm

Buschard

2019

APMIS

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“…Previous studies on the lipid profile analysis of patients with DM concerned mainly type 2 DM, where the importance of abnormalities in the lipid profile in the aetiopathogenesis of cardiovascular diseases has been confirmed [23]. Published studies on lipid profile assessments in patients with T1DM in relation to a control group without diabetes showed significantly lower levels of analysed parameters in patients with T1DM [24]. New data are expected soon from the completed Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) to provide information about potential renal and cardiovascular protective effects of ACEI and statins in high-risk adolescents [25].…”

Section: Original Papermentioning

confidence: 94%

Is treatment of type 1 diabetes mellitus (insulin therapy, metabolic control) optimal for preventing cardiovascular autonomic neuropathy?

Pawliński

Gastoł

Fiema

et al. 2019

Endokrynologia Polska

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Introduction: Long-term poor metabolic control promotes the occurrence of microvascular complications, such as cardiovascular autonomic neuropathy (CAN) and atherogenic hyperlipidaemia, which translates into increased mortality in patients with type 1 diabetes mellitus (T1DM). The aim of the study was to assess the prevalence of CAN in patients with T1DM in relation to treatment method (continuous subcutaneous insulin infusion, CSII, versus multiple daily injections using pens, MDI) and metabolic control. Material and methods: The study group comprised 93 adults (60 women, 33 men), mean age 31 years, with T1DM being treated at a local clinical centre from 2011 to 2015. The presence of CAN, the results of laboratory tests, and anthropometric data were analysed. The subjects were divided into two groups according to treatment method (CSII, MDI). Results: The median duration of diabetes was 16 years. 61% of the subjects used MDI and 39% used CSII. 41% of the subjects presented with CAN (confirmed with the Ewing test using ProSciCard apparatus), with a significantly lower prevalence in the group of patients treated with CSII (15.4% vs. 60.4%; p < 0.001). The mean HbA 1c level in the CSII-treated group was noticeably lower (7.44 ± 1.67% vs. 8.55 ± 1.1%, p < 0.001), and these patients also had lower triglyceride levels (0.71 vs. 1.32 mmol/L, p < 0.001). Regardless of the treatment method, 72% of all patients under 40 years of age achieved their therapeutic target of LDL cholesterol level < 2.6 mmol/L, whereas only 13% of all those over 40 years old achieved an LDL cholesterol level < 1.8 mmol/L. Conclusions: The presented results draw attention to the high prevalence of CAN among T1DM patients. The study reveals the need for more intensive monitoring and treatment of hyperlipidaemia, despite good glycaemic control, especially in those over the age of 40 years. (Endokrynol Pol 2019; 70 (4): 323-329)

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“…The correlation coefficient gives a linear indication of the strength of the correlation and is independent of the intensity of the variable so it is a better measure for the reliability of the variable in the classification process. Strongly discriminating variables have a clear covariance with a high absolute value for the correlation coefficient [ 43 ]. The quality of the model was evaluated by the R 2 and Q 2 values, defining the variance explained (indicating goodness of fit) and the variance predicted by the model, respectively.…”

Section: Methodsmentioning

confidence: 99%

Evolution of the metabolome in response to selection for increased immunity in populations of Drosophila melanogaster

et al. 2017

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We used NMR-based metabolomics to test two hypotheses–(i) there will be evolved differences in the metabolome of selected and control populations even under un-infected conditions and (ii) post infection, the metabolomes of the selected and control populations will respond differently. We selected replicate populations of Drosophila melanogaster for increased survivorship (I) against a gram-negative pathogen. We subjected the selected (I) and their control populations (S) to three different treatments: (1) infected with heat-killed bacteria (i), (2) sham infected (s), and (3) untreated (u). We performed 1D and 2D NMR experiments to identify the metabolic differences. Multivariate analysis of the metabolic profiles of the untreated (Iu and Su) flies yielded higher concentrations of lipids, organic acids, sugars, amino acids, NAD and AMP in the Iu treatment as compared to the Su treatment, showing that even in the absence of infection, the metabolome of the I and S regimes was different. In the S and I regimes, post infection/injury, concentration of metabolites directly or indirectly associated with energy related pathways (lipids, organic acids, sugars) declined while the concentration of metabolites that are probably associated with immune response (amino acids) increased. However, in most cases, the I regime flies had a higher concentration of such metabolites even under un-infected conditions. The change in the metabolite concentration upon infection/injury was not always comparable between I and S regimes (in case of lactate, alanine, leucine, lysine, threonine) indicating that the I and S regimes had evolved to respond differentially to infection and to injury.

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Metabolic profiling of type 1 diabetes mellitus in children and adolescents: a case–control study

Cited by 41 publications

References 24 publications

L‐serine: a neglected amino acid with a potential therapeutic role in diabetes

L‐serine: a neglected amino acid with a potential therapeutic role in diabetes

Is treatment of type 1 diabetes mellitus (insulin therapy, metabolic control) optimal for preventing cardiovascular autonomic neuropathy?

Evolution of the metabolome in response to selection for increased immunity in populations of Drosophila melanogaster

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