Metabolic protein kinase signalling in neuroblastoma

Smiles, William J.; Catalano, Luca; Stefan, Victoria E.; Weber, Daniela D.; Kofler, Barbara

doi:10.1016/j.molmet.2023.101771

Cited by 4 publications

(4 citation statements)

References 228 publications

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“…Overall, this results in the self-renewal of tumour cells [ 45 ]. In fact, targeted therapy for MYCN is usually not possible since there are two extended α-helices in the DNA binding domain that do not allow for interaction with small molecules [ 46 ].…”

Section: Neuroblastoma and Oxidative Stressmentioning

confidence: 99%

Section: Neuroblastoma and Oxidative Stressmentioning

confidence: 99%

“…These cells can shift from glycolysis for oxidative phosphorylation when glucose availability is limited. Overall, MYCN amplification can promote both glycolysis and oxidative phosphorylation in NB [46]. DPYSL3, which is an indicator of a good prognosis, encodes the dihydropyrimidinaselike protein 3 and is a member of the DPYSL gene family, which is normally expressed in the nervous system, particularly in the developmental stages.…”

Section: Definitions and Characteristics Of Neuroblastomamentioning

confidence: 99%

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Olive Oil Components as Novel Antioxidants in Neuroblastoma Treatment: Exploring the Therapeutic Potential of Oleuropein and Hydroxytyrosol

Gonçalves,

Aiello,

Rodríguez-Pérez

et al. 2024

Nutrients

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In this review, we explored the therapeutic potential of oleuropein (OLE) and hydroxytyrosol (HT) in the treatment of neuroblastoma (NB). NB is an extracranial tumour that predominantly affects children aged between 17 and 18 months. Recurrence and drug resistance have emerged as the biggest challenges when treating NB, leading to a crucial need for new therapeutic approaches. Food of the Mediterranean Diet (MD) presents several health benefits, including that of cancer treatment. In this review, we emphasised olive oil since it is one of the main liquid ingredients of the MD. OLE is the principal phenolic compound that constitutes olive oil and is hydrolysed to produce HT. Considering that tumour cells produce increased amounts of reactive oxygen species, this review highlights the antioxidant properties of OLE and HT and how they could result in increased cellular antioxidant defences and reduced oxidative damage in NB cells. Moreover, we highlight that these phenolic compounds lead to apoptosis and cell cycle arrest, reduce the side effects caused by conventional treatments, and activate tumours that become dormant as a resistance mechanism. Future research should explore the effects of these compounds and other antioxidants on the treatment of NB in vivo.

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Section: Neuroblastoma and Oxidative Stressmentioning

confidence: 99%

Section: Neuroblastoma and Oxidative Stressmentioning

confidence: 99%

Section: Definitions and Characteristics Of Neuroblastomamentioning

confidence: 99%

See 1 more Smart Citation

Olive Oil Components as Novel Antioxidants in Neuroblastoma Treatment: Exploring the Therapeutic Potential of Oleuropein and Hydroxytyrosol

Gonçalves,

Aiello,

Rodríguez-Pérez

et al. 2024

Nutrients

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show abstract

“…In the therapeutic studies of esophageal squamous cell carcinoma, MAP2K3 inhibitors have been reported to be effective in inhibiting cell growth. MAP2K3 can mediate cellular responses to external stimuli by phosphorylating and activating the p38-MAPK signaling pathway ( 8 ). When cells are subjected to external stimuli, activated MAP3K activates MAP2K3 to phosphorylate and activate the p38-MAPK signaling pathway.…”

Section: Introductionmentioning

confidence: 99%

Exploring MAP2K3 as a prognostic biomarker and potential immunotherapy target in glioma treatment

Pu,

Feng,

et al. 2024

Front. Neurol.

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Glioma, the most prevalent primary brain tumor in adults, is characterized by significant invasiveness and resistance. Current glioma treatments include surgery, radiation, chemotherapy, and targeted therapy, but these methods often fail to eliminate the tumor completely, leading to recurrence and poor prognosis. Immune checkpoint inhibitors, a class of commonly used immunotherapeutic drugs, have demonstrated excellent efficacy in treating various solid malignancies. Recent research has indicated that unconventional levels of expression of the MAP2K3 gene closely correlates with glioma malignancy, hinting it could be a potential immunotherapy target. Our study unveiled substantial involvement of MAP2K3 in gliomas, indicating the potential of the enzyme to serve as a prognostic biomarker related to immunity. Through the regulation of the infiltration of immune cells, MAP2K3 can affect the prognosis of patients with glioma. These discoveries establish a theoretical foundation for exploring the biological mechanisms underlying MAP2K3 and its potential applications in glioma treatment.

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Empagliflozin mitigates cardiac hypertrophy through cardiac RSK/NHE-1 inhibition

Chen,

Overberg,

Ghouse

et al. 2024

Biomedicine & Pharmacotherapy

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Metabolic protein kinase signalling in neuroblastoma

Cited by 4 publications

References 228 publications

Olive Oil Components as Novel Antioxidants in Neuroblastoma Treatment: Exploring the Therapeutic Potential of Oleuropein and Hydroxytyrosol

Olive Oil Components as Novel Antioxidants in Neuroblastoma Treatment: Exploring the Therapeutic Potential of Oleuropein and Hydroxytyrosol

Exploring MAP2K3 as a prognostic biomarker and potential immunotherapy target in glioma treatment

Empagliflozin mitigates cardiac hypertrophy through cardiac RSK/NHE-1 inhibition

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