Metabolic Regulation of Methionine Restriction in Diabetes

Yin, Jie; Ren, Wenkai; Chen, Shuai; Li, Yuying; Han, Hui; Gao, Jing; Liu, Gang; Wu, Xin; Li, Tiejun; Kim, Sung Woo; Yin, Yulong

doi:10.1002/mnfr.201700951

Cited by 45 publications

(34 citation statements)

References 111 publications

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“…Similar results were found in grouper ( Epinephelus coioides ) fed a Met deficient levels (7.1 g/kg) diet, which showed increased PEPCK activity (Chi et al, ). Dietary Met restriction might impair Akt activation and thus lower glucose utilization (Yin et al, ). In addition, 12.4 g/kg dietary Met decreased gluconeogenesis capacity by down‐regulating PCPEK mRNA levels, indicating that the optimal dietary Met suppresses gluconeogenesis and promotes glycolysis, leading to optimal use of energy sources to maintain the maximum growth in juvenile cobia (Figure ).…”

Section: Discussionmentioning

confidence: 99%

Dietary methionine affects growth and the expression of key genes involved in hepatic lipogenesis and glucose metabolism in cobia (Rachycentron canadum)

Chi

Zhu

et al. 2019

Aquacult Nutr

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Juvenile cobia (Rachycentron canadum), a carnivorous fish, was chosen to examine the effects of methionine (Met) supplementation of low fishmeal diets on growth and the expression of key genes related to hepatic lipogenesis and glucose metabolism. Seven isonitrogenous and isolipidic diets were formulated to contain 7.2, 9.0, 10.0, 12.4, 14.1, 16.3 and 18.6 g/kg dietary Met levels. Healthy cobia (initial average weight ± SE = 9.79 ± 0.04 g) were randomly assigned into seven groups in triplicate with 40 individuals per sea cage for 8 weeks. The results showed that the weight gain rate (WGR) of fish increased as the dietary Met was increased up to 12.4 g/kg and then decreased. The expression of insulin‐like growth factor‐I (IGF‐I) and target of rapamycin (TOR) genes was inhibited by the Met‐deficient diets. The mRNA levels of fatty acid synthase (FAS) and sterol regulatory element‐binding protein‐1 (SREBP1) genes increased with increasing dietary Met until 12.4 g/kg after which the former remained constant, whereas the latter decreased from 12.4 to 18.6 g/kg Met. The mRNA levels of pyruvate kinase (PK) increased as the dietary Met levels increased, reaching a peak at 12.4 g/kg, and then decreased with further increases in Met. However, the mRNA levels of phosphoenolpyruvate carboxykinase (PEPCK) decreased as the dietary Met was increased up to 12.4 g/kg and then remained constant from 12.4 to 18.6 g/kg Met. In conclusion, based on the straight broken‐line analysis of WGR against dietary Met levels, the optimal dietary Met requirement for juvenile cobia was estimated to be 12.4 g/kg (26.9 g/kg dietary protein). A diet with the optimal level of Met induces fish growth and is associated with increased IGF‐I and TOR.

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Section: Discussionmentioning

confidence: 99%

Dietary methionine affects growth and the expression of key genes involved in hepatic lipogenesis and glucose metabolism in cobia (Rachycentron canadum)

Chi

Zhu

et al. 2019

Aquacult Nutr

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“…[25] The potential underlying mechanisms here might be associated with improving metabolic flexibility, enhancing antioxidant activity, and stimulating the synthesis of fibroblast growth factor 21 (FGF21). [26] MR also ameliorates learning and memory impairments and reduces oxidative stress in the rat brain. [27] Moreover, potential implications of the relationship between MR and the gut microbiome were suggested by the finding that restriction of sulfur-containing amino acids improved barrier function by markedly upregulating Claudins.…”

Section: Introductionmentioning

confidence: 90%

Methionine Restriction Regulates Cognitive Function in High‐Fat Diet‐Fed Mice: Roles of Diurnal Rhythms of SCFAs Producing‐ and Inflammation‐Related Microbes

Wang

Ren

Hui

et al. 2020

Molecular Nutrition Food Res

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Scope Methionine restriction (MR) is known to potently alleviate inflammation and improve gut microbiome in obese mice. The gut microbiome exhibits diurnal rhythmicity in composition and function, and this, in turn, drives oscillations in host metabolism. High‐fat diet (HFD) strongly altered microbiome diurnal rhythmicity, however, the role of microbiome diurnal rhythmicity in mediating the improvement effects of MR on obesity‐related metabolic disorders remains unclear. Methods and results 10‐week‐old male C57BL/6J mice are fed a low‐fat diet or HFD for 4 weeks, followed with a full diet (0.86% methionine, w/w) or a methionine‐restricted diet (0.17% methionine, w/w) for 8 weeks. Analyzing microbiome diurnal rhythmicity at six time points, the results show that HFD disrupts the cyclical fluctuations of the gut microbiome in mice. MR partially restores these cyclical fluctuations, which lead to time‐specifically enhance the abundance of short‐chain fatty acids producing bacteria, increases the acetate and butyric, and dampens the oscillation of inflammation‐related Desulfovibrionales and Staphylococcaceae over the course of 1 day. Notably, MR, which protects against systemic inflammation, influences brain function and synaptic plasticity. Conclusion MR could serve as a potential nutritional intervention for attenuating obesity‐induced cognitive impairments by balancing the circadian rhythm in microbiome‐gut‐brain homeostasis.

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“…首先, 蛋氨酸在细胞内能够直接与自由基反应从而达到清除自由基的目的. 其次, 蛋氨酸能够合成半胱氨酸, 对机体抗氧化系统起到间接调节作用 [57,58] . 然而, 研究发现动物模型添加过量的蛋氨酸能够显著增加同型半胱氨酸含量和 DNA甲酰化紊乱几率, 并进一步直接诱导线粒体产生自由基, 造成氧化应激 [57,59] .…”

Section: 谷氨酸属于酸性氨基酸通过腹腔注射敌草快建立仔猪氧化应激模型本研究组前期试验发现饲料中unclassified