Metabolic regulation on the immune environment of glioma through gut microbiota

Lyu, Yingying; Yang, Hui; Liang, Chen

doi:10.1016/j.semcancer.2021.05.005

Cited by 34 publications

(38 citation statements)

References 98 publications

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Section: Discussionmentioning

confidence: 99%

“…The proven mechanisms include binding with G protein-coupled receptors (GPCRs) and inhibition of histone deacetylase (HDAC) ( 33 ). Parts of SCFAs in the circulation can enter the CNS, especially when the blood–brain barrier is breached ( 26 , 34 ). SCFAs were found to affect the NF-κB pathway in tumor cells and immune cells.…”

Section: Discussionmentioning

confidence: 99%

“…The NF-κB pathway affects the production of inflammatory factors such as IL-6 and IL-8 to regulate the tumor microenvironment and promote the development of glioma. SCFAs can also induce Treg differentiation and IL-10 secretion ( 26 ). Therefore, further experiments should explore the relationship between Bacteroidia and its metabolites with glioma growth through metabolomic analysis.…”

Section: Discussionmentioning

confidence: 99%

“…The role of the gut microbiome in the immune system has also been well studied in germ-free (GF) animals. GF animals have severe immune deficiencies, which are manifested as defects in lymphoid structure and immune function, demonstrating that the GM is essential for the activation and function of immune cells (16,26) diseases that the number of CD4+T cells in the small intestine of antibiotic-treated mice was significantly increased, indicating the correlation between GM and adaptive immunity (11). Our results have proved that the gut microbiome dysbiosis in mice can lead to the decrease of Foxp3 expression in the glioma microenvironment and promote the development of glioma, further indicating that GM have a certain effect on adaptive immunity.…”

Section: Discussionmentioning

confidence: 99%

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Gut Microbiome Alterations Affect Glioma Development and Foxp3 Expression in Tumor Microenvironment in Mice

Fan

Chen

et al. 2022

Front. Oncol.

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Glioma is the most common malignant tumor of the central nervous system (CNS), with high degree of malignancy and poor prognosis. The gut microbiome (GM) is composed of microorganisms with different properties and functions, which play an important role in human physiology and biological activities. It has been proved that GM can affect the development of glioma through natural immunity, but whether GM can affect glioma through adaptive immunity and whether there are some microorganisms in the GM that may affect glioma growth still remain unclear. In our study, we evaluated the relationship between GM and glioma. We proved that (I) glioma growth can induce structural changes of mouse GM, including the decreased abundance of Bacteroidia and increased abundance of Firmicutes. (II) GM dysbiosis can downregulate Foxp3 expression in the brain and promote glioma growth. A balanced environment of GM can upregulate the expression of Foxp3 in the brain and delay the development of glioma. (III) The increased abundance of Bacteroidia is associated with accelerated glioma progression, while its decreased abundance is associated with delayed glioma progression, which may be one of the key microorganisms affecting glioma growth. This study is helpful to reveal the relationship between GM and glioma development and provide new ideas for adjuvant therapy of glioma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Gut Microbiome Alterations Affect Glioma Development and Foxp3 Expression in Tumor Microenvironment in Mice

Fan

Chen

et al. 2022

Front. Oncol.

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“…The functional prediction showed that environmental information processing, such as CAMs and ECM-receptor interactions, was significantly higher in HGG patients than in the HCs. Several CAMs, such as neural cell adhesion molecule L1, have been identified to underlie the occurrence of glioma malignancies ( Senner et al, 2002 ; Jiang et al, 2019 ; Lyu et al, 2021 ). ECM plays an important role in gliomas, such as in the higher expression of laminin a2 in glioblastoma ( Lathia et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Association Between Oral Microbiota and Human Brain Glioma Grade: A Case-Control Study

et al. 2021

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Gliomas are the most prevalent form of primary malignant brain tumor, which currently have no effective treatments. Evidence from human studies has indicated that oral microbiota is closely related to cancers; however, whether oral microbiota plays a role in glioma malignancy remains unclear. The present study aimed to investigate the association between oral microbiota and grade of glioma and examine the relationship between malignancy-related oral microbial features and the isocitrate dehydrogenase 1 (IDH1) mutation in glioma. High-grade glioma (HGG; n=23) patients, low-grade glioma (LGG; n=12) patients, and healthy control (HCs; n=24) participants were recruited for this case-control study. Saliva samples were collected and analyzed for 16S ribosomal RNA (rRNA) sequencing. We found that the shift in oral microbiota β-diversity was associated with high-grade glioma (p=0.01). The phylum Patescibacteria was inversely associated with glioma grade (LGG and HC: p=0.035; HGG and HC: p<0.01). The genera Capnocytophaga (LGG and HC: p=0.043; HGG and HC: p<0.01) and Leptotrichia (LGG and HC: p=0.044; HGG and HC: p<0.01) were inversely associated with glioma grades. The genera Bergeyella and Capnocytophaga were significantly more positively correlated with the IDH1 mutation in gliomas when compared with the IDH1-wild-type group. We further identified five oral microbial features (Capnocytophaga Porphyromonas, Haemophilus, Leptotrichia, and TM7x) that accurately discriminated HGG from LGG (area under the curve [AUC]: 0.63, 95% confidence interval [CI]: 0.44–0.83) and HCs (AUC: 0.79, 95% CI: 0.68–0.92). The functional prediction analysis of oral bacterial communities showed that genes involved in cell adhesion molecules (p<0.001), extracellular matrix molecule-receptor interaction (p<0.001), focal adhesion (p<0.001), and regulation of actin cytoskeleton (p<0.001) were associated with glioma grades, and some microbial gene functions involving lipid metabolism and the adenosine 5'-monophosphate-activated protein kinase signaling pathway were significantly more enriched in IDH1 mutant gliomas than compared with the IDH1-wild-type gliomas. In conclusion, our work revealed oral microbiota features and gene functions that were associated with glioma malignancy and the IDH1 mutation in glioma.

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Metabolic heterogeneity in tumor microenvironment – A novel landmark for immunotherapy

Chen,

Han,

Qing

2024

Autoimmunity Reviews

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Metabolic regulation on the immune environment of glioma through gut microbiota

Cited by 34 publications

References 98 publications

Gut Microbiome Alterations Affect Glioma Development and Foxp3 Expression in Tumor Microenvironment in Mice

Gut Microbiome Alterations Affect Glioma Development and Foxp3 Expression in Tumor Microenvironment in Mice

Association Between Oral Microbiota and Human Brain Glioma Grade: A Case-Control Study

Metabolic heterogeneity in tumor microenvironment – A novel landmark for immunotherapy

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