Metabolic remodelling of mice by hypoxic-hypercapnic environment: imitating the naked mole-rat

Lifespan Extension in Long-Lived Vertebrates Rooted in Ecological Adaptation

“…Hypoxia adaptation induces hypothermia and hypo-metabolism, which are physiological hallmarks similar to hibernating species and CR animals, and with links to extended lifespan ( Lewis et al, 2018 ). Likewise, mice exposed to a model of NMR natural environment (hypoxic–hypercapnic environment) exhibit a significant decrease in both body temperature and metabolic rate as observed in CR and mutant mice ( Conti et al, 2006 ; Tolstun et al, 2020 ). There were no significant expression changes in stress-related genes, while also displaying accelerated wound healing ( Tolstun et al, 2020 ).…”

“…Likewise, mice exposed to a model of NMR natural environment (hypoxic–hypercapnic environment) exhibit a significant decrease in both body temperature and metabolic rate as observed in CR and mutant mice ( Conti et al, 2006 ; Tolstun et al, 2020 ). There were no significant expression changes in stress-related genes, while also displaying accelerated wound healing ( Tolstun et al, 2020 ).…”

Hypercapnia-inducible factor: a hypothesis

“…As for the examples of possible cooperation, it was shown that the healing process of the damaged endothelial layer was suppressed under hypoxia, while under the simultaneous action of hypoxia and hypercapnia wound healing was activated by stimulating cell proliferation [21]. We also observed accelerated skin wound healing of mice exposed to HHE, despite the decreased metabolic rate and body temperature [22]. The metabolism suppressing effects of HHE could be an important and evolutionary well-preserved phenomenon mediated by coordinated gene expression.…”

ASIC1a Stimulates the Resistance of Human Hepatocellular Carcinoma by Promoting Epithelial-mesenchymal Transition via the AKT/GSK3β/Snail Signaling Pathway

“…Due to excessive rapid growth, the tumor cells often form hypoxic environment. 37 And hypoxia can induce the transformation of cell metabolism and promote the increase of acidosis, thereby producing high acid load. 38 At this time, the tumor cells can adapt to the acidic microenvironment by changing the metabolic to turn on the detoxi cation mode.…”

“…The anti-ASIC1a (1: 200) antibody was applied in IF according to our previously described method. 37 Alexa Fluor 488-conjugated goat anti-rabbit IgG (H+L) (1: 1000, Abcam, Cambridge, UK) was used as uorescent secondary antibodies. For nuclear staining, cells were incubated with DAPI for 10 min.…”