Metabolic Reprogramming and Cancer: 2022

Abstract

Cancer is a disease that is considered as a silent killer. Early therapeutic interventions can lead to cure from the disease. The causal reasons for cancer are many. At the molecular level, metabolic reprogramming is a process for self-renewal and survival by the cancer cells. Dietary constituents is an important factor that leads into metabolic transitions and induce cellular reprogramming. The process is initiated by inducing changes in metabolism leading to supply of nutrients and energy to the tumour cells, and this is linked to the induction of EMT and VM. Thermodynamic changes that gets distinguished in proliferating and non-proliferating cells might also be a possible reason for cellular reprogramming. The entire process of metabolic reprogramming is linked to diet driven changes and bioenergetics. The work here elucidates in brief dependency of metabolic reprogramming on different factors, or stages and highlights possibilities for therapeutic interventions as part of cancer therapeutics.