Metabolic Reprogramming and Renal Fibrosis

Zhu, Xiaoyu; Jiang, Lili; Long, Mengtuan; Wei, Xuejiao; Hou, Yue; Du, Yujun

doi:10.3389/fmed.2021.746920

Cited by 27 publications

(24 citation statements)

References 177 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since HIF–1α is a transcriptional factor that promotes the expression of several genes involved in glycolysis [ 37 , 38 ], we next explored its levels in whole tissue lysates, observing that HIF–1α tends to increase along the UUO progression. However, a significant increase was observed only at 21 days of the UUO compared to the sham group ( Figure 6 C).…”

Section: Resultsmentioning

confidence: 99%

Expression Profiles of Kidney Mitochondrial Proteome during the Progression of the Unilateral Ureteral Obstruction: Focus on Energy Metabolism Adaptions

et al. 2022

View full text Add to dashboard Cite

Kidney diseases encompass many pathologies, including obstructive nephropathy (ON), a common clinical condition caused by different etiologies such as urolithiasis, prostatic hyperplasia in males, tumors, congenital stenosis, and others. Unilateral ureteral obstruction (UUO) in rodents is an experimental model widely used to explore the pathophysiology of ON, replicating vascular alterations, tubular atrophy, inflammation, and fibrosis development. In addition, due to the kidney’s high energetic demand, mitochondrial function has gained great attention, as morphological and functional alterations have been demonstrated in kidney diseases. Here we explore the kidney mitochondrial proteome differences during a time course of 7, 14, and 21 days after the UUO in rats, revealing changes in proteins involved in three main metabolic pathways, oxidative phosphorylation (OXPHOS), the tricarboxylic acid cycle (TCA), and the fatty acid (FA) metabolism, all of them related to bioenergetics. Our results provide new insight into the mechanisms involved in metabolic adaptations triggered by the alterations in kidney mitochondrial proteome during the ON.

show abstract

Section: Resultsmentioning

confidence: 99%

Expression Profiles of Kidney Mitochondrial Proteome during the Progression of the Unilateral Ureteral Obstruction: Focus on Energy Metabolism Adaptions

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Based on the circRNA-related regulatory network, we identified two hub genes, circSlc8a1 and circApoe, which might be involved in the pathogenesis of renal fibrosis by sponging multiple DE miRNAs and their downstream targeted DE mRNAs. Metabolic disturbance has been increasingly recognized as an important pathogenic process that underlies renal fibrosis, and development of drugs for metabolic reprogramming will be a promising anti-fibrotic therapy ( Zhao et al, 2020 ; Zhu et al, 2021 ). This study might provide a new perspective on renal fibrosis and contribute to the development of novel therapeutics for CKD.…”

Section: Discussionmentioning

confidence: 99%

Integrated Analysis of the CircRNA-Based ceRNA Network in Renal Fibrosis Induced by Ischemia Reperfusion Injury

Wei

Liu

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

Background: Circular RNAs (circRNAs), which have broad posttranscriptional regulatory potencies, are involved in the pathogenesis of fibrotic diseases and are promising diagnostic biomarkers and therapeutic targets. However, their specific roles in renal fibrosis remain elusive.Methods: A robust unilateral renal ischemia reperfusion injury (UIRI) mouse model was established to recapitulate the pathophysiology of renal fibrosis. The expression of circRNAs, miRNAs, and mRNAs was profiled by high-throughput RNA sequencing technology.Results: In total, 4983 circRNAs, 216 miRNAs, and 6371 mRNAs were differentially expressed in UIRI-induced fibrotic kidneys. Candidate circRNAs and miRNAs were validated by RT–qPCR in both UIRI and unilateral ureteral obstruction mouse models. Bioinformatic analysis indicated that the parental genes of the differentially expressed circRNAs were predominantly implicated in focal adhesion, adhesion junctions, and regulation of actin cytoskeleton pathways. Through circRNA-miRNA-mRNA construction, we identified two hub genes, circSlc8a1 and circApoe, that targeted a large number of differentially expressed miRNAs and mRNAs related to metabolism and cytokine–cytokine receptor pathways, respectively.Conclusion: CircRNAs were dysregulated in the UIRI model and might be potentially involved in the pathogenesis of renal fibrosis. Research efforts should focus on unravelling the functions of aberrantly expressed circRNAs in renal fibrosis to uncover biomarkers that would enable early diagnosis and the design of prompt therapeutic interventions to prevent disease progression.

show abstract

“…Sirt1 has recently been found to act as an important regulator of immune cells and immune responses ( Shen et al, 2021 ), which deserves the attention of researchers studying kidney diseases. In addition, metabolic reprogramming has been an emerging hotspot of kidney disease research in recent years, and changes in fatty acid metabolism and glucose metabolism have been found to be closely related to renal fibrosis ( Zhu et al, 2021 ). Sirt1 plays an important role in energy and metabolic regulation ( Ong and Ramasamy, 2018 ), and therefore, sirt1 may mediate metabolic reprogramming and play an important role in renal diseases.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive bibliometric analysis of sirtuins: Focus on sirt1 and kidney disease

Liu

Yang

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Sirtuins, as regulators of metabolism and energy, have been found to play an important role in health and disease. Sirt1, the most widely studied member of the sirtuin family, can ameliorate oxidative stress, immune inflammation, autophagy, and mitochondrial homeostasis by deacetylating regulatory histone and nonhistone proteins. Notably, sirt1 has gradually gained attention in kidney disease research. Therefore, an evaluation of the overall distribution of publications concerning sirt1 based on bibliometric analysis methods to understand the thematic evolution and emerging research trends is necessary to discover topics with potential implications for kidney disease research. We conducted a bibliometric analysis of publications derived from the Web of Science Core Collection and found that publications concerning sirt1 have grown dramatically over the past 2 decades, especially in the past 5 years. Among these, the proportion of publications regarding kidney diseases have increased annually. China and the United States are major contributors to the study of sirt1, and Japanese researchers have made important contributions to the study of sirt1 in kidney disease. Obesity, and Alzheimer’s disease are hotspots diseases for the study of sirt1, while diabetic nephropathy is regarded as a research hotspot in the study of sirt1 in kidney disease. NAD+, oxidative stress, and p53 are the focus of the sirt1 research field. Autophagy and NLRP3 inflammasome are emerging research trends have gradually attracted the interest of scholars in sirt1, as well as in kidney disease. Notably, we also identified several potential research topics that may link sirt1 and kidney disease, which require further study, including immune function, metabolic reprogramming, and fecal microbiota.

show abstract

Metabolic Reprogramming and Renal Fibrosis

Cited by 27 publications

References 177 publications

Expression Profiles of Kidney Mitochondrial Proteome during the Progression of the Unilateral Ureteral Obstruction: Focus on Energy Metabolism Adaptions

Expression Profiles of Kidney Mitochondrial Proteome during the Progression of the Unilateral Ureteral Obstruction: Focus on Energy Metabolism Adaptions

Integrated Analysis of the CircRNA-Based ceRNA Network in Renal Fibrosis Induced by Ischemia Reperfusion Injury

Comprehensive bibliometric analysis of sirtuins: Focus on sirt1 and kidney disease

Contact Info

Product

Resources

About