Metabolic Reprogramming in Cancer

Prusty, Debasish; Manna, Subal Chandra

doi:10.1002/9781119851042.ch25

Cited by 1 publication

(1 citation statement)

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“…Research evidence suggests that leucine metabolism is indeed dysregulated in AML. Enhanced expression of leucine transporters, particularly LAT1, has been observed in leukemic cells, signifying an augmented demand for leucine to support their heightened proliferation rates (6). Furthermore, alterations in the activity and expression of enzymes involved in leucine metabolism, such as BCAT1 and LHD, have been documented in AML, implicating leucine metabolism as a potential therapeutic target (7).…”

Section: Introductionmentioning

confidence: 99%

Exploiting leucine metabolism for therapeutic benefit in acute Myeloid Leukemia

Md Rakibul Hasan,

Johnathon Hall,

Faisal Ahmed

2024

GSC Adv. Res. Rev.

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Acute Myeloid Leukemia (AML) presents significant challenges in treatment, especially for elderly patients. Conventional therapies have limitations, necessitating the exploration of novel strategies. Metabolic reprogramming in cancer cells offers promise in this regard, with growing evidence pointing to dysregulated leucine metabolism in AML. Leucine deprivation has shown potential in inhibiting leukemic cell proliferation, inducing cell cycle arrest, and enhancing differentiation. Combination therapies involving leucine deprivation and chemotherapy have exhibited synergistic effects. The precise molecular mechanisms of leucine deprivation's anti-leukemic effects, particularly its potential impact on the mTOR signaling pathway, require further elucidation. Targeting BCAAs and other amino acids, such as methionine and lysine, holds promise in disrupting leukemia cell proliferation and promoting apoptosis. These findings underscore the potential of exploiting leucine metabolism and amino acid pathways for therapeutic benefits in AML.

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Section: Introductionmentioning

confidence: 99%