Metabolic Response Assessment in Non-Small Cell Lung Cancer Patients after Platinum-Based Therapy: A Preliminary Analysis

Stefano, Alessandro; Porcino, Nunziatina; Banna, Giuseppe Luigi; Russo, Giorgio; Mocciaro, Vanessa; Anile, Giuseppe; Gieri, Stefania; Cosentino, Sebastiano; Murè, Gabriella; Baldari, S; Sabini, M.G.; Sardina, D.; Fraggetta, Filippo; Vitabile, Salvatore; Gilardi, Maria Carla; Ippolito, Massimo

doi:10.2174/157340561104150727165035

Cited by 9 publications

(6 citation statements)

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“…Nevertheless, the measurement of PET volumes provides only volumetric information and does not assess metabolic activity; parameters that combine the volumetric and metabolic information, such as the total lesion glycolysis (TLG), can provide a better evaluation of prognosis. A number of studies have shown the usefulness of TLG as a predictive parameter to guide treatment decisions in different cancers ( 27 – 31 ). Maximum SUV, MTV and TLG may be considered as predictive and risk stratification markers for the management of cervical cancer patients ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Correlation between histological grade and positron emission tomography parameters in cervical carcinoma

et al. 2016

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The aim of the present study was to evaluate the changes in cervical cancer glucose metabolism for different levels of cellular differentiation. The metabolic activity was measured by standardized uptake value (SUV), SUV normalized to lean body mass, metabolic tumor volume and total lesion glycolysis using fluorine-18 fluorodeoxyglucose positron emission tomography (PET). A correlation study of these values could be used to facilitate therapeutic choice and to improve clinical practice and outcome. This study considered 32 patients with diagnosed cervical cancers, at different International Federation of Gynecology and Obstetrics stages. Glucose metabolism was assessed by PET examination, and histological specimens were examined to determine their initial grade of differentiation. A correlation study of these values was evaluated. Histological examination showed that all cases were of squamous cell carcinoma. Regarding the differentiation of the tumor, 19 well- to moderately-differentiated tumors and 13 poorly-differentiated tumors were determined. Negative findings for correlations between metabolic parameters and initial grade of histological differentiation were found, and considering that histological grade has been shown to have no consistent prognostic value in cervical cancer treatment, PET imaging could play a significant role in cervical cancer prognosis.

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Section: Introductionmentioning

confidence: 99%

Correlation between histological grade and positron emission tomography parameters in cervical carcinoma

et al. 2016

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“…Based on this value, it is possible to distinguish between progressive disease if ΔSUV>25%, stable disease if −15%<ΔSUV < 25%, and partial response if ΔSUV < −15%, as previously reported 60 . In the same way, ΔTLG and ΔMTV were calculated.…”

Section: Suv ¼ Radioactivity Of the Tumor Injected Radioactivity Body...mentioning

confidence: 76%

Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model

et al. 2023

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Despite aggressive therapeutic regimens, glioblastoma (GBM) represents a deadly brain tumor with significant aggressiveness, radioresistance and chemoresistance, leading to dismal prognosis. Hypoxic microenvironment, which characterizes GBM, is associated with reduced therapeutic effectiveness. Moreover, current irradiation approaches are limited by uncertain tumor delineation and severe side effects that comprehensively lead to unsuccessful treatment and to a worsening of the quality of life of GBM patients. Proton beam offers the opportunity of reduced side effects and a depth-dose profile, which, unfortunately, are coupled with low relative biological effectiveness (RBE). The use of radiosensitizing agents, such as boron-containing molecules, enhances proton RBE and increases the effectiveness on proton beam-hit targets. We report a first preclinical evaluation of proton boron capture therapy (PBCT) in a preclinical model of GBM analyzed via μ-positron emission tomography/computed tomography (μPET-CT) assisted live imaging, finding a significant increased therapeutic effectiveness of PBCT versus proton coupled with an increased cell death and mitophagy. Our work supports PBCT and radiosensitizing agents as a scalable strategy to treat GBM exploiting ballistic advances of proton beam and increasing therapeutic effectiveness and quality of life in GBM patients.

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“…The biological tumor volume (BTV) identified by PET can be used to treat the cancer region more precisely [11]. Furthermore, PET imaging has become a standard component of diagnosis and staging in oncology [12][13][14][15][16]. Functional changes are often faster and more indicative of the effects caused by therapy than anatomical imaging, providing a faster method of detecting the treatment response [17,18].…”

Section: Introductionmentioning

confidence: 99%

Early Monitoring Response to Therapy in Patients with Brain Lesions Using the Cumulative SUV Histogram

et al. 2021

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Gamma Knife treatment is an alternative to traditional brain surgery and whole-brain radiation therapy for treating cancers that are inaccessible via conventional treatments. To assess the effectiveness of Gamma Knife treatments, functional imaging can play a crucial role. The aim of this study is to evaluate new prognostic indices to perform an early assessment of treatment response to therapy using positron emission tomography imaging. The parameters currently used in nuclear medicine assessments can be affected by statistical fluctuation errors and/or cannot provide information on tumor extension and heterogeneity. To overcome these limitations, the Cumulative standardized uptake value (SUV) Histogram (CSH) and Area Under the Curve (AUC) indices were evaluated to obtain additional information on treatment response. For this purpose, the absolute level of [11C]-Methionine (MET) uptake was measured and its heterogeneity distribution within lesions was evaluated by calculating the CSH and AUC indices. CSH and AUC parameters show good agreement with patient outcomes after Gamma Knife treatments. Furthermore, no relevant correlations were found between CSH and AUC indices and those usually used in the nuclear medicine environment. CSH and AUC indices could be a useful tool for assessing patient responses to therapy.

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Metabolic Response Assessment in Non-Small Cell Lung Cancer Patients after Platinum-Based Therapy: A Preliminary Analysis

Cited by 9 publications

References 0 publications

Correlation between histological grade and positron emission tomography parameters in cervical carcinoma

Correlation between histological grade and positron emission tomography parameters in cervical carcinoma

Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model

Early Monitoring Response to Therapy in Patients with Brain Lesions Using the Cumulative SUV Histogram

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