2018
DOI: 10.1096/fasebj.2018.32.1_supplement.816.5
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Metabolic stress directs WNK kinases to aggresomes for pooling and degradation in the distal convoluted tubule of the kidney

Abstract: ObjectiveRenal salt retention due to excessive function of the renal NaCl cotransporter (NCC) along the distal convoluted tubule (DCT) plays a central role in the pathogenesis of hypertension. The Western type diet with high salt and low potassium content (HS/LK) has been shown to increase NCC activity by stimulating its phosphorylation via a kinase cascade comprising with‐no‐lysine kinases (WNKs) and a Ste20‐related kinase (SPAK). WNKs and SPAK have been shown to accumulate in perinuclear aggregates in respon… Show more

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