Metabolic studies on the human heart in vivo

Bing, Richard J.; Taeschler, M; Siegel, A.; Vitale, A; Balboni, Fiamma

doi:10.1016/0002-9343(53)90397-0

Cited by 6 publications

(6 citation statements)

References 28 publications

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“…The myocardial oxygen extraction expressed as a percentage value of arterial oxygen saturation as well as the oxygen consumption values in m l/100 g of muscle (table IV) are no different from values reported for man [Bing et al, 1953;G o r l in , 1960;L in deneg et al, 1964; W e n d t et a /., 1965],…”

Section: Discussionmentioning

confidence: 57%

“…Although arterial values of glucose do not appear to be different in Papio and man [Bing et al, 1953;Sundemeyer et a!., 1961], the baboon heart showed a greater extraction of glucose. Arterial values of pyruvate and lactate, as well as the extraction of these substrates, particularly lactates, are higher in the baboon than in reported human subjects [Bing et al, 1953;L in d en eg e7cr/., 1964;W en d t et al, 1965].…”

Section: Discussionmentioning

confidence: 71%

“…Arterial values of pyruvate and lactate, as well as the extraction of these substrates, particularly lactates, are higher in the baboon than in reported human subjects [Bing et al, 1953;L in d en eg e7cr/., 1964;W en d t et al, 1965]. On the other hand, arterial levels of free fatty acids are higher in man [Ballard eta/., 1960;Bing etal., 1953Bing etal., /1954L in d en eg et al, 1964], but the myocardial extraction appears to be similar.…”

Section: Discussionmentioning

confidence: 96%

“…On the other hand, arterial levels of free fatty acids are higher in man [Ballard eta/., 1960;Bing etal., 1953Bing etal., /1954L in d en eg et al, 1964], but the myocardial extraction appears to be similar. The A redox potential as determined from pyruvate/lactate ratios is positive for both man and Papio [Brink and Lew is, 1967;W en d t et a!., 1965], Myocardial usage of all three carbohydrate substrates as well as free fatty acids appears to be higher for Papio [Ballard et a!., 1960;Bing et al, 1953Bing et al, , 1954Brink and L ew is, 1967;L in d en eg et a!., 1964;Sundemeyer et a!., 1961].…”

Section: Discussionmentioning

confidence: 99%

“…Metabolic studies Aliquots of arterial and coronary venous blood taken during each coronary flow determination were analyzed for glucose, pyruvate, lactate, and free fatty acid (FFA) contents according to enzymatic and titrimetric methods previously described [Brink and Lewis, 1967], It has been shown that these substrates account for over 90 per cent of myocardial substrate utilization in man [Bing et al, 1953[Bing et al, /1954, Oxygen extraction ratios for the various substrates were calculated as the oxygen equivalent of the arteriovenous differ ence of the substrate, expressed as a percentage of the overall arteriovenous difference across the myocardium [Bing el al., 1953]. Myocardial consumption of the various carbohydrate and fatty acid substrates was calculated as the product of the coronary arteriovenous difference of each substance and the coronary blood flow.…”

Section: Coronary Artery Anatomymentioning

confidence: 99%

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The Baboon (Papio ursinus) Heart (Coronary Blood Supply, Muscle Function and Metabolism)

Brink¹,

Lewis²,

Bosman³

et al. 1970

IJFP

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The sub-human primate baboon (Papio ursinus) was subjected to cardiac catheterisation studies and pathologic injection techniques with a view to establishing baseline values pertaining to coronary artery morphology, coronary blood flow and myocardial energetics and metabolism. The similarities to the human situation (and minor differences) are considered in the light of possible extrapolation to clinical conditions in contemplated future experimental studies of myocardial physiology.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Coronary Artery Anatomymentioning

confidence: 99%

See 3 more Smart Citations

The Baboon (Papio ursinus) Heart (Coronary Blood Supply, Muscle Function and Metabolism)

Brink¹,

Lewis²,

Bosman³

et al. 1970

IJFP

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Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions Potential for pharmacological interventions

Stanley

Lopaschuk

Hall

et al. 1997

Cardiovascular Research

515

435

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It is now clear that the availability of different metabolic substrates can have a profound influence on the extent of damage incurred during episodes of cardiac ischaemia, and on cardiac functional recovery on reperfusion following ischaemia. In particular, increases in fatty acid availability and oxidation, compared to glucose oxidation, under such conditions leads to a worsening of outcome. Therefore metabolic interventions aimed at enhancing glucose utilisation and pyruvate oxidation at the expense of fatty acid oxidation is a valid therapeutic approach to the treatment of myocardial ischaemia. In particular, the development of agents which will promote full glucose oxidation as opposed to glycolysis alone, offer clear advantages. This can be accomplished by different means, including direct or indirect inhibition of CPT-I or inhibition of fatty acid beta-oxidation, or by direct or indirect activation of PDH. It is not yet clear which of these approaches offers the best treatment of cardiac ischaemia. To date, trimetazidine and carnitine have received limited approval in Europe for the treatment of angina; large scale clinical trials with the other agents mentioned above have not been completed. The increasing availability of agents affecting these specific sites, and the increasingly sophisticated techniques for assessing myocardial metabolism, should allow elucidation of the optimum metabolic targets and development of novel pharmacological agents for the treatment of ischaemic heart disease.

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A study of glycogen and lactate in the myotomal muscles and liver of the Coalfish (Gadus virensL.) during sustained swimming

Johnston

Goldspink

1973

J. Mar. Biol. Ass.

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The locomotor roles of the myotomal muscles of fish are dependent on swimming speed. The mean maximum sustained swimming speed for coalfish (Gadus virens L.) during a 6-h period in an experimental exercise chamber was determined using a fixedvelocity technique and found to be 4 bodylengths/s. Biochemical measurements were made on the concentration of glycogen and lactate in the red muscle and white muscle at a series of known swimming speeds. Evidence is provided that red muscle alone is used at speeds below 2 bodylengths/s. The fall in concentration of red muscle glycogen was directly proportional to increased swimming speed. At speeds in excess of 2 bodylengths/s a statistically significant increase in lactate concentration occurred in the white muscle fibres. A reduction in glycogen content of the white muscle was also noted at speeds at and above the estimated mean sustained swimming speed. These results are discussed in the light of the current ideas pertaining to the division of labour between myotomal muscles in fish.

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Metabolic studies on the human heart in vivo

Cited by 6 publications

References 28 publications

The Baboon (Papio ursinus) Heart (Coronary Blood Supply, Muscle Function and Metabolism)

The Baboon (Papio ursinus) Heart (Coronary Blood Supply, Muscle Function and Metabolism)

Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions Potential for pharmacological interventions

A study of glycogen and lactate in the myotomal muscles and liver of the Coalfish (Gadus virensL.) during sustained swimming

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