Metabolic study of ginsenoside Rg3 and glimepiride in type 2 diabetic rats by liquid chromatography coupled with quadrupole‐Orbitrap mass spectrometry

Yang, Di; Li, Xue; Fu, Yunhua; Tao, Xingyu; Zheng, Fei; Yu, Jinlong; Hao, Yanpeng; Dai, Yulin

doi:10.1002/rcm.9083

Cited by 8 publications

(3 citation statements)

References 35 publications

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“…The mass spectrum data of YLTZC were gained by UPLC-Q-TOF-MS/MS. As shown in Table 2, a total of 66 chemical constituents were characterized by reference standards, reference literature, mass fragments, and mass spectrometry databases [21][22][23][24][25][26][27][28][29][30][31][32] . The main chemical constituent cluster was composed of 42 flavonoids, 6 saponins, 4 coumarins, 4 lactones, 9 organic acids and 1 limonin.…”

Section: Resultsmentioning

confidence: 99%

Deciphering the mechanisms of Yinlan Tiaozhi capsule in treating hyperlipidemia by combining network pharmacology, molecular docking and experimental verification

Xiao¹,

Hu²,

Jia

et al. 2023

Sci Rep

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Yinlan Tiaozhi capsule (YLTZC) has been widely used to treat hyperlipidemia (HLP). However, its material basis and underlying pharmacological effects remain unclean. The current study aimed to explore the mechanisms involved in the treatment of YLTZC on HLP based on network pharmacology, molecular docking, and experimental verification. Firstly, UPLC-Q-TOF–MS/MS was used to comprehensively analyze and identify the chemical constituents in YLTZC. A total of 66 compounds, mainly including flavonoids, saponins, coumarins, lactones, organic acids, and limonin were characterized and classified. Simultaneously, the mass fragmentation pattern of different types of representative compounds was further explored. By network pharmacology analysis, naringenin and ferulic acid may be the core constituents. The 52 potential targets of YLTZC, including ALB, IL-6, TNF, and VEGFA, were considered potential therapeutic targets. Molecular docking results showed that the core active constituents of YLTZC (naringenin and ferulic acid) have a strong affinity with the core targets of HLP. Lastly, animal experiments confirmed that naringenin and ferulic acid significantly upregulated the mRNA expression of ALB and downregulated the mRNA expression of IL-6, TNF, and VEGFA. In sum, the constituents of YLTZC, such as naringenin and ferulic acid, might treat HLP by regulating the mechanism of angiogenesis and inhibiting inflammatory responses. Furthermore, our data fills the gap in the material basis of YLTZC.

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Section: Resultsmentioning

confidence: 99%

Deciphering the mechanisms of Yinlan Tiaozhi capsule in treating hyperlipidemia by combining network pharmacology, molecular docking and experimental verification

Xiao¹,

Hu²,

Jia

et al. 2023

Sci Rep

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“…The effects of different modes of administration on the metabolic half-life of ginsenosides are highly heterogeneous. When ginsenoside Rg3 was administered intravenously in rats, its half-life was 14 min [ 38 ] and 18.5 min [ 39 ] in separate studies. The variations in the metabolic time of ginsenoside Rg3 in rats can be attributed to the dissimilar solubility of ginsenoside Rg3 and heterogeneity in its absorption and utilization within rats.…”

Section: Metabolic Shift and Pharmacokinetic Changes Of Ginsenosides ...mentioning

confidence: 99%

Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer

Jiang,

Fang,

Zhang

et al. 2023

Chin Med

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In 2021, breast cancer accounted for a substantial proportion of cancer cases and represented the second leading cause of cancer deaths among women worldwide. Although tumor cells originate from normal cells in the human body, they possess distinct biological characteristics resulting from changes in gene structure and function of cancer cells in contrast with normal cells. These distinguishing features, known as hallmarks of cancer cells, differ from those of normal cells. The hallmarks primarily include high metabolic activity, mitochondrial dysfunction, and resistance to cell death. Current evidence suggests that the fundamental hallmarks of tumor cells affect the tissue structure, function, and metabolism of tumor cells and their internal and external environment. Therefore, these fundamental hallmarks of tumor cells enable tumor cells to proliferate, invade and avoid apoptosis. Modifying these hallmarks of tumor cells represents a new and potentially promising approach to tumor treatment. The key to breast cancer treatment lies in identifying the optimal therapeutic agent with minimal toxicity to normal cells, considering the specific types of tumor cells in patients. Some herbal medicines contain active ingredients which can precisely achieve this purpose. In this review, we introduce Ginsenoside's mechanism and research significance in achieving the therapeutic effect of breast cancer by changing the functional hallmarks of tumor cells, providing a new perspective for the potential application of Ginsenoside as a therapeutic drug for breast cancer.

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“…Ginseng, the root of Panax ginseng C. A. Meyer, has been used for thousands of years as a traditional Chinese medicine (TCM) in Asian countries to strengthen immunity, supply nutrition, and decrease fatigue. Ginsenosides are the major active components in ginseng, having a variety of bioactive and pharmacological activities, including anticancer, 1,2 antitumor, 3,4 antidiabetic, 5,6 antihypertensive, 7 antifatigue, 8 and antiaging effects 9 . More than 500 kinds of ginsenosides have been identified from ginseng and related herbs 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Ultrahigh‐performance liquid chromatography coupled to ion mobility quadrupole time‐of‐flight mass spectrometry profiling and unveiling the transformation of ginsenosides by the dual conditions of citric acid and high‐pressure steaming

et al. 2022

Rapid Comm Mass Spectrometry

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Rationale: Many methods have been reported for the production of rare ginsenosides, including heat treatment, acid hydrolysis, alkaline hydrolysis, enzymatic hydrolysis, and microbial transformation. However, the conversion of original ginsenosides to rare ginsenosides under the dual conditions of citric acid and highpressure steam sterilization has rarely been reported.Methods: In this study, a method involving ultrahigh-performance liquid chromatography coupled to ion mobility quadrupole time-of-flight mass spectrometry was developed for analysis of chemical transformation of protopanaxatriol (PPT)-type ginsenosides Rg 1 and Re, protopanaxadiol (PPD)-type ginsenoside Rb 1 , and total ginsenosides in the dual conditions of citric acid and highpressure steam sterilization. An internal ginsenoside database containing 126 known ginsenosides and 18 ginsenoside reference compounds was established to identify the transformation products and explore possible transformation pathways and mechanisms.Results: A total of 54 ginsenosides have been preliminarily identified in the transformation products of PPD-type ginsenosides Rg 1 and Re, PPD-type ginsenoside Rb 1 , and total ginsenosides, and the possible transformation pathways were as follows:

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Metabolic study of ginsenoside Rg3 and glimepiride in type 2 diabetic rats by liquid chromatography coupled with quadrupole‐Orbitrap mass spectrometry

Cited by 8 publications

References 35 publications

Deciphering the mechanisms of Yinlan Tiaozhi capsule in treating hyperlipidemia by combining network pharmacology, molecular docking and experimental verification

Deciphering the mechanisms of Yinlan Tiaozhi capsule in treating hyperlipidemia by combining network pharmacology, molecular docking and experimental verification

Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer

Ultrahigh‐performance liquid chromatography coupled to ion mobility quadrupole time‐of‐flight mass spectrometry profiling and unveiling the transformation of ginsenosides by the dual conditions of citric acid and high‐pressure steaming

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