Metabolic syndrome – a new definition and management guidelines
A joint position paper by the Polish Society of Hypertension, Polish Society for the Treatment of Obesity, Polish Lipid Association, Polish Association for Study of Liver, Polish Society of Family Medicine, Polish Society of Lifestyle Medicine, Division of Prevention and Epidemiology Polish Cardiac Society, “Club 30” Polish Cardiac Society, and Division of Metabolic and Bariatric Surgery Society of Polish Surgeons

Dobrowolski, Piotr; Prejbisz, Aleksander; Kuryłowicz, Alina; Baska, Alicja; Burchardt, Paweł; Chlebus, Krzysztof; Dzida, Grzegorz; Jankowski, Piotr; Jaroszewicz, Jerzy; Jaworski, Paweł; Kamiński, Karol; Kapłon‐Cieślicka, Agnieszka; Klocek, Marek; Kukla, Michał; Mamcarz, Artur; Mastalerz-Migas, Agnieszka; Ostrowska, Lucyna; Śliż, Daniel; Tarnowski, Wiesław; Wolf, Jacek; Wyleżoł, Mariusz; Zdrojewski, Tomasz; Banach, Maciej; Januszewicz, Andrzej; Bogdański, Paweł

doi:10.5114/aoms/152921

Cited by 96 publications

(72 citation statements)

References 81 publications

(107 reference statements)

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“…The exclusion criteria were represented by patients with cardiovascular risk factors under treatment, medical or surgical comorbidities associated with a pro-inflammatory status, or treated with drugs mediating inflammation. In addition, we excluded patients with 3 of 5 of the criteria for metabolic syndrome [ 11 , 12 ] or those participating at the same time in another clinical trial. Patients included in the study had no associated cardiovascular risk factors requiring drug treatment.…”

Section: Methodsmentioning

confidence: 99%

Determinants of Arterial Stiffness in Patients with Morbid Obesity. The Role of Echocardiography and Carotid Ultrasound Imaging

et al. 2023

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Background and objective: Morbid obesity is accompanied by an increased cardiovascular (CV) risk, which justifies a multidisciplinary, integrative approach. Arterial stiffness has a well-defined additional role in refining individual CV risk. Given that echocardiography and carotid ultrasound are usual methods for CV risk characterization, we aimed to identify the imaging parameters with a predictive value for early-onset arterial stiffness. Material and methods: We conducted a study in which 50 patients (divided into two equal groups with morbid obesity and without obesity), age and gender matched, untreated for cardiovascular risk factors, were addressed to bariatric surgery or non-inflammatory benign pathology surgery. Before the surgical procedures, we evaluated demographics, anthropometric data and biochemical parameters including adipokines (chemerin, adiponectin). Arterial stiffness was evaluated using the Medexpert ArteriographTM TL2 device. Transthoracic echocardiography and carotid ultrasound were also performed. We also analyzed adipocyte size and vascular wall thickness in intraoperative biopsies. Results: Left ventricle (LV) mass index (p = 0.2851), LV ejection fraction (LVEF) (p = 0.0073), epicardial adipose tissue thickness (p = 0.0001) as echocardiographic parameters and carotid intima–media thickness (p = 0.0033), relative wall thickness (p = 0.0295), wall to lumen thickness ratio (p = 0.0930) and carotid cross-sectional area (p = 0.0042) as ultrasound parameters were significant measures in our groups and were assessed in relation to adipocyte size, blood vessel wall thickness and adipokines serum levels. Statistical analysis revealed directly proportional relationships between LV mass index (p = 0.008), carotid systolic thickness of the media (p = 0.009), diastolic thickness of the media (p = 0.007), cross-sectional area (p = 0.001) and blood vessel wall thickness. Carotid relative wall thickness positively correlates with adipocyte size (p = 0.023). In patients with morbid obesity, chemerin and adiponectin/chemerin ratio positively correlates with carotid intima–media thickness (p = 0.050), systolic thickness of the media (p = 0.015) and diastolic thickness of the media (p = 0.001). The multiple linear regression models revealed the role of epicardial adipose tissue thickness and carotid cross-sectional area in predicting adipocyte size which in turn is an independent factor for arterial stiffness parameters such as pulse wave velocity, subendocardial viability ratio and aortic augmentation index. Conclusions: Our results suggest that epicardial adipose tissue thickness, carotid intima–media thickness, relative wall thickness and carotid cross-sectional area might be useful imaging parameters for early prediction of arterial stiffness in patients with morbid obesity.

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Section: Methodsmentioning

confidence: 99%

Determinants of Arterial Stiffness in Patients with Morbid Obesity. The Role of Echocardiography and Carotid Ultrasound Imaging

et al. 2023

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“…MetS was defined according to Dobrowolski P et al newly proposed criteria for the MetS. 5 According to this new point, a person has MetS when:…”

Section: Metabolic Syndrome Criteria and High Blood Pressure Definitionmentioning

confidence: 99%

“…4 In the meantime, a new definition has been proposed. 5 In the new definition, HBP is considered a key feature of MetS. 6 Also, MetS is accompanied by a pro-inflammatory state which explains the elevation of various inflammatory markers such as hs-CRP, insulin resistance which results in increased obesity-induced systemic oxidative stress and activates downstream inflammatory cascades, leading to tissue fibrosis, atherogenesis, and, subsequently CVD.…”

Section: Introductionmentioning

confidence: 99%

Effects of cardiometabolic risk factors on blood pressure in outpatients at Sominé DOLO hospital, Mopti, Mali

Coulibaly¹,

Kondé²,

Traoré³

et al. 2023

IJCBR

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Blood cardiometabolic impairments are associated to high blood pressure which is a pivot cardiovascular risk factor. The objective of this study was to assess cardiometabolic risk factors rates in subjects with high blood pressure in the steady state. A total of 292subjects, 107 cases and 185 controls were enrolled in cross-sectional study. Clinical and biological data were assessed during visits and after overnight fasting. Data were analyzed on R. A p-value < 0.05 was considered for statistical significance.Univariate analysis showed thatage > 50 years, visceral obesity, metabolic syndrome and hs- CRP ≥ 3 mg/L were significant predictors of high blood pressure: OR = 2.1, 95% CI [1.3-3.5], p = 0.003; OR = 1.6, 95% CI [1.0-2.6], p = 0.05; OR = 3.3; 95% CI [2.0-5.4], p < 0.001; OR = 16.8; 95% CI [9.4-31.4], p < 0.001, respectively. Multivariate analysis showed a positive association between obesity, metabolic syndrome, hs-CRP and high blood pressure: aOR = 2.29; 95% CI [1.14-4.69], p = 0.02; aOR = 3.47; 95% CI [1.64-7.61], p = 0.001; aOR = 18.10; CI, 2.5% to 95% [9.40-36.99], p < 0.001, respectively. In contrast, female sex was negatively associated with high blood pressure aOR = 0.31; CI, 95% CI [0.13-0.72], p < 0.008. Prevention policiesshould take into account blood cardiometabolic level for subjects with high blood pressure even though in the steady sate.

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“…The presence of obesity together with two of the three additional diagnostic criteria (elevated blood pressure, impaired carbohydrate metabolism, or elevated nonhigh-density lipoprotein cholesterol) is referred to as metabolic syndrome (MetS). The development of obesity and MetS components significantly increases the risk of cardiovascular events [40]. In addition, VDD may be associated with, among others, increased levels of nonlipid biomarkers of cardiovascular risk, such as high sensitivity C-reactive protein, cystatin-C, creatinine, uric acid, or hemoglobin A1c (HbA1c) [41].…”

Section: Recent Findingsmentioning

confidence: 99%

Impact of vitamin D receptor polymorphisms in selected metabolic disorders

Fronczek

Osadnik

Banach

2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

Self Cite

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Purpose of reviewVitamin D (vitD) can regulate metabolic pathways in adipose tissue and pancreatic β cells by interacting with its vitamin D receptor (VDR). The aim of this study was to review original publications published in the last months and verify the relationship between genetic variants in the VDR gene and type 2 diabetes (T2D), metabolic syndrome (MetS), overweight, and obesity.Recent findingsThe recent studies concern genetic variants located in the coding and noncoding regions of the VDR gene. Some of the described genetic variants may affect VDR expression or posttranslational processing altered functionality or vitD binding capacity of VDR. Nevertheless, the data collected in recent months on the assessment of the relationship between VDR genetic variants and the risk of T2D, MetS, overweight, and obesity still do not give a clear answer to whether they have a direct impact on these metabolic disorders.SummaryAnalysis of the potential association between VDR genetic variants and parameters such as glycemia, body mass index, body fat, and lipid levels improves the current understanding of the pathogenesis of T2D, MetS, overweight, and obesity. A thorough understanding of this relationship may provide important information for individuals with pathogenic variants and enable the implementation of appropriate prevention against the development of these disorders.

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Cited by 96 publications

References 81 publications

Determinants of Arterial Stiffness in Patients with Morbid Obesity. The Role of Echocardiography and Carotid Ultrasound Imaging

Determinants of Arterial Stiffness in Patients with Morbid Obesity. The Role of Echocardiography and Carotid Ultrasound Imaging

Effects of cardiometabolic risk factors on blood pressure in outpatients at Sominé DOLO hospital, Mopti, Mali

Impact of vitamin D receptor polymorphisms in selected metabolic disorders

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