Metabolic Syndrome after Bariatric Surgery. Results Depending on the Technique Performed

Gracia-Solanas, Jose Antonio; Elía, M.; Aguilella, V.; Ramı́rez, José M.; Martínez, José Mário; Bielsa, M. A.; Martínez, Mariano

doi:10.1007/s11695-010-0309-6

Cited by 39 publications

(13 citation statements)

References 32 publications

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“…Addressing the hedonic mechanisms of overconsumption in obesity by performing NAS DBS may provide therapeutic relief to certain individuals who are refractory to current approaches (Jeffery et al, 2004; Li et al, 2005; Gracia-Solanas et al, 2011). The nucleus accumbens is critical in mediating reward-seeking behaviors, including binge eating (Avena et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Amelioration of Binge Eating by Nucleus Accumbens Shell Deep Brain Stimulation in Mice Involves D2 Receptor Modulation

Halpern¹,

et al. 2013

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Hedonic over-consumption contributing to obesity involves altered activation within the mesolimbic dopamine system. Dysregulation of dopamine signaling in the nucleus accumbens shell (NAS) has been implicated in reward-seeking behaviors, such as binge eating, which contributes to treatment resistance in obesity (Wise, 2012). Direct modulation of the NAS with deep brain stimulation (DBS), a surgical procedure currently under investigation in humans for the treatment of major depression, obsessive-compulsive disorder, and addiction, may also be effective in ameliorating binge eating. Therefore, we examined the ability of DBS of the NAS to block this behavior in mice. c-Fos immunoreactivity was assessed as a marker of DBS-mediated neuronal activation. NAS DBS was found to reduce binge eating, and increased c-Fos levels in this region. DBS of the dorsal striatum had no influence on this behavior, demonstrating anatomical specificity for this effect. The dopamine D2 receptor antagonist, raclopride, attenuated the action of DBS, while the D1 receptor antagonist, SCH-23390, was ineffective, suggesting that dopamine signaling involving D2 receptors underlies the effect of NAS DBS. To determine the potential translational relevance to the obese state, chronic NAS DBS was also examined in diet-induced obese mice, and was found to acutely reduce caloric intake and induce weight loss. Taken together, these findings support the involvement of the mesolimbic dopamine pathways in the hedonic mechanisms contributing to obesity, and the efficacy of NAS DBS to modulate this system.

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Section: Discussionmentioning

confidence: 99%

Amelioration of Binge Eating by Nucleus Accumbens Shell Deep Brain Stimulation in Mice Involves D2 Receptor Modulation

Halpern¹,

et al. 2013

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“…However, when revaluated at 7 years of follow-up, the percentage of patients submitted to vertical banded gastroplasty and LRYGB that presented MS resumed to near preoperative values owing to weight regain, which did not occur after biliopancreatic diversion yet at the expense of a higher morbidity rate [42]. …”

Section: Discussionmentioning

confidence: 99%

Excess body mass index loss predicts metabolic syndrome remission after gastric bypass

Nora

Guimarães

Almeida

et al. 2014

Diabetol Metab Syndr

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BackgroundMetabolic syndrome (MS) is a condition associated with obesity that identifies individuals with increased cardiovascular risk. Gastric bypass improves several MS components, such as glucose, lipid metabolism and hypertension. The aim of this study was to evaluate the effect of long-limb gastric bypass on the remission of MS criteria associated with morbid obesity.MethodsObese patients who met the “harmonized” criteria for MS (n = 153) that underwent laparoscopic Roux-en-Y gastric bypass (LRYGB) with a long biliopancreatic limb were prospectively evaluated with regards to body weight, body mass index (BMI), percentage of excess BMI lost (% EBMIL), fasting glucose, blood pressure and lipid profile up to 36 months after surgery.ResultsBefore surgery, patients had a BMI of 44.3 ± 0.5 kg/m2; 66% were under anti-diabetic treatment; 78.4% were under anti-hypertensive treatment and 44.3% were under anti-dyslipidemic treatment. After a mean follow-up time of 2.4 ± 0.1 years, MS remission rates were 32.7% at 6 months, 69.7% at 12 months, 63.4% at 24 months, and 59.2% at 36 months; when only 32.9%, 43.4% and 15.8% of patients were still under anti-diabetic, anti-hypertensive and anti-dyslipidemic treatment, respectively. The %EBMIL and BMI were the parameters that showed the highest accuracy to predict the MS remission at all-time points after the surgery.ConclusionsLong limb gastric bypass in obese patients results in significant and sustained weight loss which predicts a high remission rate of MS and allows the discontinuation of drug therapy for several metabolic disturbances in most patients.

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“…Please cite this article in press as: Iannelli Although the efficacy of bariatric surgery on the MetS has been investigated in several single procedure reports [17][18][19], only three studies compared the LRYGBP with the LSG, recently accepted as a stand-alone bariatric procedure capable of resolving the MetS after surgery [5,20,21]. In a series of 91 morbidly obese patients undergoing LRYGBP (52 patients) and LSG (39 patients), Vidal et al found a comparable resolution rate 1 year after surgery (62.2% vs. 67.3%, respectively) [20].…”

Section: Discussionmentioning

confidence: 99%

Evolution of low-grade systemic inflammation, insulin resistance, anthropometrics, resting energy expenditure and metabolic syndrome after bariatric surgery: A comparative study between gastric bypass and sleeve gastrectomy

Iannelli

Anty

Schneck

et al. 2013

Journal of Visceral Surgery

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Metabolic Syndrome after Bariatric Surgery. Results Depending on the Technique Performed

Cited by 39 publications

References 32 publications

Amelioration of Binge Eating by Nucleus Accumbens Shell Deep Brain Stimulation in Mice Involves D2 Receptor Modulation

Amelioration of Binge Eating by Nucleus Accumbens Shell Deep Brain Stimulation in Mice Involves D2 Receptor Modulation

Excess body mass index loss predicts metabolic syndrome remission after gastric bypass

Evolution of low-grade systemic inflammation, insulin resistance, anthropometrics, resting energy expenditure and metabolic syndrome after bariatric surgery: A comparative study between gastric bypass and sleeve gastrectomy

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