Metabolic syndrome after risk-reducing salpingo-oophorectomy in women at high risk for hereditary breast ovarian cancer: A controlled observational study

Bilateral Oophorectomy and the Risk of Incident Diabetes in Postmenopausal Women

“…In women who had undergone oophorectomy, Dørum et al (29) and Michelsen et al (30) each reported a higher prevalence and incidence of metabolic syndrome, and women who undergo hysterectomy with or without BSO, because of anovulation, may have polycystic ovary disease. Although the cause of the association between hysterectomy with or without BSO and diabetes is uncertain, these findings offer a potential hormonal-metabolic mechanism to explain the elevated risk of diabetes among women with BSO in the current study.…”

Risk reducing salpingectomy and delayed oophorectomy in high risk women: views of cancer geneticists, genetic counsellors and gynaecological oncologists in the UK

“…While data related to neurological consequences are more limited and emerging, [24,25] the impact on higher risk of heart disease is more substantial and well established. [20][21][22] Compared to geneticists, gynaecologists were half as aware of the 50% reduction in breast cancer risk with premenopausal RRSO. While a number of analyses in the high-risk [19,36] women have shown this benefit, a recent Dutch paper published after this survey [37] underlined methodological deficiencies in earlier analyses [36,38,39] and reported no benefit of breast cancer risk reduction from premenopausal RRSO.…”

“…[16][17][18] It is the most effective option for preventing tubal/ ovarian cancer, with a hazard ratio (HR) of 0.21 (95%CI 0.12, 0.39) [19] reported in a recent meta-analysis in known BRCA1 and BRCA2 carriers. Although, the benefits of RRSO are significant, decision making is a complex process with many women and clinicians concerned over the side effects of premature surgical menopause, such as: a higher risk of cardiovascular disease, [20][21][22] potential cognitive impairment and Parkinsonism, [23][24][25] osteoporosis, vasomotor symptoms, and detrimental impact on quality of life. [26,27] Premature menopause has been shown to have a mortality impact [28] in low risk women.…”

Screening of the residual normal ovarian tissue adjacent to orthotopic epithelial ovarian carcinomas in nude mice

“…A considerable portion of women with epithelial ovarian cancer are in their childbearing age. The absence of ovarian function will lead to early menopause, with symptoms such as hot flashes, insomnia, body aches, irritability, more serious genitourinary tract infections, and earlier appearance of related diseases such as osteoporosis, coronary heart disease, and metabolic syndrome (Michelsen et al, 2009). Besides, the quality of life of patients is compromised (Finch and Narod, 2011).…”