Metabolic syndrome among adolescents in Dubai, United Arab Emirates, is attributable to the high prevalence of low HDL levels: a cross-sectional study

Haroun, Dalia; Mechli, Rola; Sahuri, Razan; Al-Khatib, Safa; Obeid, Omar; Mallah, Carla El; Wood, Lesley; Al-Suwaidi, Khulood Eid Khalfan

doi:10.1186/s12889-018-6215-x

Cited by 21 publications

(25 citation statements)

References 41 publications

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“…Low HDL-c (17%) was the most prevalent MetS component, followed by metabolic glucose (8%), raised TG (5.3%), DBP (1.4%), and high WC (0.5%). Our results are in agreement with several studies reporting HDL as the predominant risk factor among adolescents, followed by high BP, in both Saudi Arabia and the UAE; 45,61,62 with~87% of Saudi children and adolescents aged 10-18 years old had low HDL levels. 61 Moreover, a recent UAE study suggested that if MetS did not account for HDL levels, their prevalence would drop from 3.7% to 0.8%.…”

Section: Discussionsupporting

confidence: 93%

“…44 The prevalence of MetS, according to the IDF criteria, among adolescents aged 10-16 years old attending public schools in Dubai was 3.7%. 45 Similarly, the prevalence of MetS was 3% among Qatari school children, 46 2.3% among Turkish school children aged 10-19 years, 47 and 4.7% in Canadian Tsimshian Nation youth aged 6-18 years. 48 Higher prevalence of 6.3% was reported in another Turkish study in 7-15 years old children 49 and 16.5% among school-aged children in Pakistan based on various definitions.…”

Section: Discussionmentioning

confidence: 90%

“…50 However, studies that have assessed the prevalence of MetS using different diagnostic criteria have consistently reported different results sometimes differing by more than two-fold. 45 Several reports indicate that the prevalence of childhood MetS has substantially increased during childhood and adolescence due to the increasing rate of childhood obesity on a global scale. 49,51 The prevalence of MetS among obese children was reported to be more serious than that among normal weight children.…”

Section: Discussionmentioning

confidence: 99%

“…61 Moreover, a recent UAE study suggested that if MetS did not account for HDL levels, their prevalence would drop from 3.7% to 0.8%. 45 Studies investigating the genetic susceptibility to having low HDL have identified several predisposing variants among Arabs. 63 On the other hand, an Iranian study reported that 46.5% of children had at least one of the MetS components with the most prevalent MetS component was hypertension followed by abdominal obesity, hypertriglyceridemia and low HDL-C; 53 while a Turkish study showed that the variables of greatest frequency in pre-pubertal children were hypertension, hypertriglyceridemia, low HDL-C and hyperinsulinemia, with a prevalence of 32.9%, 29.4%, 23.1%, and 14.1%, respectively.…”

Section: Discussionmentioning

confidence: 99%

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<p>Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children</p>

Saeed¹,

Al‐Habori²,

Saif-Ali³

et al. 2020

DMSO

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In view of the high rate of obesity and physical inactivity as well as the rising incidence of Type 2 DM among children in the neighboring Gulf countries and Middle East region; the aim of this study was, therefore, to determine the prevalence of metabolic syndrome (MetS) and prediabetes in Yemeni school-aged children. Patients and Methods: In this study, 1402 school children aged 12-13 years old (grade 7) were recruited from public schools in the capital Sana'a during the period April-May 2013. Anthropometric measurements and BP were recorded and BMI was calculated. Fasting venous blood (5 mL) was collected for biochemical analysis including FBG, HbA1c, insulin and lipids profile. Insulin resistance (HOMA-IR) and β-cell function (HOMA-β) were calculated. Results: The prevalence of prediabetes (as defined by impaired fasting glucose) and MetS (as classified by the IDF 2007) were 0.86% and 0.5%, respectively. Our results also showed 5.21% and 20.26% of the children to have two or one factor(s) of the MetS criteria fulfilled, respectively, with low HDL-c (17%) being the most prevalent MetS component, followed by metabolic glucose (8%), raised TG (5.3%), DBP (1.4%), and high WC (0.5%). Moreover, the prevalence of overweight and obesity was 4.2% and 2.8%, respectively; and about 1.2% of children had abnormal high insulin levels. Children with impaired fasting glucose (IFG) had increased HOMA-IR (p = 0.016) and SBP (p = 0.042) and decreased HDL-c (p = 0.034) and HOMA-β (p < 0.001); whereas obese children had increased WC (p < 0.001) and TG (p = 0.049). Conclusion: The main finding of this study is that Yemeni children are at potential risk of obesity, metabolic syndrome and prediabetes despite their low prevalences. These results highlight the need for early identification and close monitoring of children at risk of later Type 2 DM as an important primary care strategy that can effectively prevent or delay the onset of such condition.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

<p>Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children</p>

Saeed¹,

Al‐Habori²,

Saif-Ali³

et al. 2020

DMSO

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“…Co-occurrence of excess body weight and lipid disorders was assessed in many populations, including studies carried out in China, Brazil, Denmark, Germany, USA, Ghana, United Arab Emirates [12][13][14][15][16][17] . Until now, however, no results have been published of similar studies on a large sample of children form a Central or Eastern European country, in which a rapid change of social and economic status of society in the last 30 years has been observed, [18].…”

Section: Introductionmentioning

confidence: 99%

Lipid disorders in children living with overweight and obesity- large cohort study from Poland

Brzeziński

Metelska²,

Myśliwiec

et al. 2020

Lipids Health Dis

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Background: While in the general paediatric population the presence of abnormal lipid values is estimated at 8-20%, depending on the population, accepted norms and age, it was shown that in the population of lean children the prevalence of dyslipidemia is lower than in obese children, in whom it ranges from 20 to over 40%. Until now, however, no results of similar studies on a large sample of children form a Central or Eastern European country have been published. The aim of this study was to evaluate the prevalence of lipid disorders in overweight and obese children and adolescents participating in an integrated weight reduction programme. Methods: According to the "6-10-14 for Health" programme implementation schedule, the programme accepted patients living in Gdańsk, aged 6, 9-11 and 14 years old, with BMI above the 85th percentile for age and sex, according to the Polish percentile charts. During the first visit, each of the participants underwent basic anthropometric examinations-body weight, body height, waist and hip circumference, blood pressure and body composition by bioelectrical impedance were measured. Blood samples were taken to assess lipid, glucose and insulin levels as well as alanine transaminase (ALT) and thyroid stimulating hormone (TSH) activity. Results: 1948 patients underwent full anthropomethric and blood work measurements. At least one of the lipid disorders occurred in 38.23% of girls and 40.51% of boys with overweight and obesity. The most common lipid disorderswere decreased high-density lipoprotein cholesterol (HDL-C) levels (present in 20.55% of the girls and 23.79% of the boys) and elevated low-density lipoprotein cholesterol (LDL-C) (present in 15.31% of the girls and 14.25% of the boys). There was no strong association between lipid disorders and age, sex, birth weight, gestational age at birth or body composition. Conclusions: Such a frequent occurrence of lipid disorders in the population of children and adolescents should be an important warning signal both at the individual and population level. Not only effective screening methods for overweight and obese children should be implemented from an early age but also therapeutic measures are required.

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