Metabolic syndrome and acute pancreatitis

Mikolašević, Ivana; Milić, Sandra; Orlić, Lidija; Poropat, Goran; Jakopčić, Ivan; Franjić, Neven; Klanac, Ana; Krišto, Nikolina; Štimac, Davor

doi:10.1016/j.ejim.2016.04.004

Cited by 58 publications

(56 citation statements)

References 18 publications

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“…Nowadays obesity is considered as a global pandemic which poses great threat to human health. Some studies have shown that obesity was positively correlated with severity of AP [37,38,12]. However, due to the paucity of studies between obesity and incidence of AP, their relationship has been a matter of dispute.…”

Section: Discussionmentioning

confidence: 99%

“…Since it is well believed that there is an interrelation between metabolic syndrome and in ammation [10,11], we suspect that metabolic syndrome may also have a signi cant impact on AP. Although some studies have demonstrated that metabolic syndrome was positively associated with the severity of AP [1,12], there is still lack of data showing the relationship between metabolic syndrome and the occurrence of AP in Chinese population. The study therefore investigated the association of metabolic syndrome and the occurrence of AP in Chinese population.…”

Section: Introductionmentioning

confidence: 99%

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Metabolic Syndrome Components and Acute pancreatitis: A Case-Control Study in China

Shen

Wang

Zhen

et al. 2020

Preprint

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Background: Acute pancreatitis (AP) is a common inflammatory disorder of pancreas. Recent evidence has shown that metabolic syndrome was positively correlated with the severity of AP. However, only few studies have revealed the relationship between metabolic syndrome and the occurrence of AP. We therefore elucidated the association between the metabolic syndrome components and the incidence rate of AP. Methods: A hospital-based case-control study was conducted. 705 patients admitted to our hospital from January 2016 to December 2018 were included in the study. Subjects were divided into case and control group according to their diagnosis: (1) According to the revised Atlanta classification from 2012, patients diagnosed as AP were enrolled into case group. (2) Patients without history of AP or any disease related to metabolic syndrome were allocated into control group. Controls were matched to cases individually by sex and age (control/case ratio=1). Risk factors were determined by univariate and multivariate logistic regression analyses. Results: The incidence rate of metabolic syndrome with AP patients was 30.9%, which was more frequent than controls (13.2%) (OR=2.975; 95%CI 1.947-4.548, p<0.001). In multivariate regression analysis, histories of smoking or alcohol drinking, biliary stone were important predictors of AP. Besides, occurrence of AP was significantly associated with total cholesterol (TC) (OR=1.831; 95%CI 1.137-2.948, p=0.013), triglyceride (TG) (OR=2.058; 95%CI 1.332-3.179, p=0.001), fasting plasma glucose (FPG) (OR =2.345; 95%CI 1.395-3.940, p=0.001), as well as low values of apolipoprotein A (Apo A) (OR =0.247; 95%CI 0.146-0.416, p<0.001). Conclusion: Metabolic syndrome and its components portend high risks of occurrence of AP.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metabolic Syndrome Components and Acute pancreatitis: A Case-Control Study in China

Shen

Wang

Zhen

et al. 2020

Preprint

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“…AP, a common acute abdominal disease, results from inflammatory reactions which damage the pancreas [3,15]. It causes acute stress, resulting in releases of various inflammatory cytokines and free radicals [3,16].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of He-Wei-Tong-Xie decoction on acute pancreatitis complicated with gastrointestinal dysfunction

Jin¹,

Li²,

Song³

et al. 2017

Trop. J. Pharm Res

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“…DM2 has been reported to cause an increase of 2-3 times in the risk of developing AP. Cirrhosis doubles the mortality in AP [30,31]. AP has also been associated with the time and duration of stress which may be beneficial or harmful to the exocrine pancreas.…”

Section: Etiologymentioning

confidence: 99%

Review of Current Evidence in Acute Pancreatitis

Varley¹,

Rossi²,

Murray³

et al. 2019

obm hg

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Acute pancreatitis (AP), an inflammatory condition of the pancreas, is one of the most common ailments of the gastrointestinal system, which results in significant morbidity and mortality. The main etiological causes of AP include alcohol consumption, gallstones, hypertriglyceridemia, and biliary stones. The clinical signs and symptoms of AP and the diagnostic criteria for this disease have been well established. Multiple scoring systems are applied to predict the severity and prognosis of AP, and the associated mortality. The present review of the literature highlights the recent significant contributions in the areas of etiology, risk factors, epidemiology, diagnosis, complications, prognosis, and the latest modalities in the treatment, which could be beneficial in the management of AP.

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Metabolic syndrome and acute pancreatitis

Cited by 58 publications

References 18 publications

Metabolic Syndrome Components and Acute pancreatitis: A Case-Control Study in China

Metabolic Syndrome Components and Acute pancreatitis: A Case-Control Study in China

Therapeutic effect of He-Wei-Tong-Xie decoction on acute pancreatitis complicated with gastrointestinal dysfunction

Review of Current Evidence in Acute Pancreatitis

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