Metabolic Syndrome and Breast Cancer: Is There a Link?

Hauner, Dagmar; Hauner, Hans

doi:10.1159/000365951

Cited by 64 publications

(64 citation statements)

References 46 publications

(59 reference statements)

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“…Moreover, increasing evidence supports a possible link between metabolic syndrome and breast cancer (Simmen & Simmen, 2011; Hauner & Hauner, 2014). A recent study from our group (Montales et al , 2014) provided a proof of this concept by using the Wnt1-Transgenic (Tg) mouse model of human breast cancer (Li et al , 2000).…”

Section: Introductionmentioning

confidence: 99%

Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice

Montales

Melnyk

Liu

et al. 2016

Endocrine-Related Cancer

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The emerging links between breast cancer and metabolic dysfunctions spawned by the obesity pandemic predict a disproportionate early disease onset in successive generations. Moreover, sensitivity to chemotherapeutic agents may be influenced by the patient’s metabolic status to affect disease outcome. Maternal metabolic stress as a determinant of drug response in progeny is not well-defined. Here, we evaluated mammary tumor response to doxorubicin in female mouse mammary tumor virus-Wnt1-transgenic offspring exposed to a metabolically-compromised environment imposed by maternal high-fat diet; control progeny were from dams consuming diets with regular fat content. Maternal high-fat diet exposure increased tumor incidence and reduced tumor latency but did not affect tumor volume response to doxorubicin, when compared to control diet exposure. However, doxorubicin-treated tumors from high-fat diet-exposed offspring demonstrated higher proliferation status (Ki-67), mammary stem cell-associated gene expression (Notch1, Aldh1), and basal stem cell-like (CD29hiCD24+) epithelial subpopulation frequencies, than tumors from control diet progeny. Notably, all epithelial subpopulations [CD29hiCD24+, CD29loCD24+, CD29hiCD24+Thy1+] in tumors from high-fat diet-exposed offspring were refractory to doxorubicin. Further, sera from high-fat diet-exposed offspring promoted sphere formation of mouse mammary tumor epithelial cells and of human MCF7 cells. Untargeted metabolomics analyses identified higher levels of kynurenine and 2-hydroxyglutarate in plasma of high-fat diet than control diet offspring. Kynurenine/doxorubicin co-treatment of MCF7 cells enhanced mammosphere-formation ability and decreased apoptosis, relative to doxorubicin only-treated cells. Maternal metabolic dysfunctions during pregnancy and lactation may be targeted to reduce breast cancer risk and improve early drug response in progeny and may inform clinical management of disease.

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Section: Introductionmentioning

confidence: 99%

Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice

Montales

Melnyk

Liu

et al. 2016

Endocrine-Related Cancer

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“…On the one hand, the type 2 diabetes mellitus (T2D) is believed to be the risk factor on the incidence of breast cancer, colorectal cancer, gastrointestinal malignancies, pancreatic cancer, renal cancer, bladder cancer, and thyroid cancer [3][4][5][6][7][8][9][10][11]. On the other hand, the cancer patients with diabetes have worse long-term outcome [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Metformin use improves the survival of diabetic combined small-cell lung cancer patients

et al. 2015

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Metformin has been reported having potential anticancer effect on kinds of solid tumors, but its role in combined small-cell lung cancer (C-SCLC) remains indistinct. This study aimed to explore whether metformin use has a prognosis benefit in diabetic C-SCLC patients. A total of 259 C-SCLC patients with diabetes were enrolled in our study. The clinicopathological parameters and survival data were collected and analyzed. The correlation between metformin use and clinicopathological characters was analyzed. Univariate and multivariate analyses were performed to investigate the prognostic significance of metformin use for C-SCLC. The metformin was used in 120 (46.3 %) patients. Our data showed that the metformin use decreased C-SCLC recurrence rate (p = 0.001). The median overall survival (OS) and disease-free survival (DFS) were significantly better in the metformin use group compared to non-metformin group (OS 19.0 vs 11.5 months, p < 0.001; DFS 10.5 vs 7.0 months, p < 0.001). Multivariate analyses indicated that metformin use was an independent prognostic factor for OS and DFS (p = 0.001 vs p = 0.018). The metformin use improved the long-term outcome of C-SCLC patients with diabetes, which might be considered a potential useful prognostic indicator and anticancer drug.

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“…(20) Of note is that some studies report categorical data that excessive body fat represents a risk factor to increase incidence of breast cancer, particularly among women in postmenopausal period. (21,22) …”

Section: Discussionmentioning

confidence: 99%

Associated factors with mammographic changes in women undergoing breast cancer screening

Santana

Mattos

Silva

et al. 2016

Einstein (São Paulo)

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Objective:To evaluate association of sociodemographic, anthropometric, and epidemiological factors with result of mammogram in women undergoing breast cancer screening.Methods:This is a cross-sectional study with data obtained through interviews, anthropometric measurements, and mammography of 600 women aged 40 to 69 years at the Preventive Medicine Department of Hospital de Câncer de Barretos, Brazil, in 2014. The results of these examinations in the BI-RADS categories 1 and 2 were grouped and classified in this study as normal mammogram outcome, and those of BI-RADS categories 3, 4A, 4B, 4C, and 5 were grouped and classified as altered mammogram outcome. The statistical analysis included the Student's t-test to compare means, as well as odds ratios (OR), with their corresponding 95% confidence intervals (95%CI), to verify an association by means of the multivariate analysis.Results:Of 600 women evaluated, 45% belonged to the age group of 40–49 years-old and 60.2% were classified as BI-RADS category 2. The multivariate analysis showed that women with blood hypertension (OR: 2.64; 95%CI: 1.07–6.49; p<0.05) were more likely to present changes in the mammography, while physical activity was associated with lower chances (OR: 0.30; 95%CI: 0.11–0.81; p<0.05).Conclusion:Hypertensive women undergoing screening mammography are more likely to present mammographic changes, whereas women practicing physical activity have lower chances (70%) of presenting changes in the breast compared with sedentary individuals.

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Metabolic Syndrome and Breast Cancer: Is There a Link?

Cited by 64 publications

References 46 publications

Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice

Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice

Metformin use improves the survival of diabetic combined small-cell lung cancer patients

Associated factors with mammographic changes in women undergoing breast cancer screening

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