Metabolic syndrome and cognitive impairment amongst elderly people in Chinese population: a cross‐sectional study

Liu, C.‐Y.; Zhou, Hua‐Dong; Xu, Zhi‐Qiang; Zhang, W.‐W.; Li, X.‐Y.; Zhao, Jiangang

doi:10.1111/j.1468-1331.2009.02640.x

Cited by 22 publications

(18 citation statements)

References 36 publications

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“…Surprisingly, other factors such as hyperglycaemia and hypertension were not statistically associated with cognitive impairment in our study. These results contradict some previous studies [6, 24], specifically the study performed by Friedman et al, who found that hypertension increased the risk for cognitive impairment [13]. One explanation could be the differences between populations, especially the relatively young average age in our study (36.6 years) compared with previous studies (47.3 years in Friedman's study).…”

Section: Discussioncontrasting

confidence: 99%

Are Cardiovascular Risk Factors Associated with Verbal Learning and Memory Impairment in Patients with Schizophrenia? A Cross-Sectional Study

Lançon

Dassa

Fernandez

et al. 2012

Cardiovascular Psychiatry and Neurology

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Objective. The aim of this study is to assess the relationships of cardiovascular risk factors with verbal learning and memory in patients with schizophrenia. Methods and Design. cross-sectional study. Inclusion Criteria. Diagnosis of schizophrenia according to the DSM-IV-TR criteria. Data Collection. Sociodemographic information, clinical characteristics, anthropometric measurements, blood tests, and episodic memory using the California Verbal Learning Test (CVLT). Analysis. A multivariate analysis using multiple linear regressions was performed to determine variables that are potentially associated with verbal learning and memory. Results. One hundred and sixty-eight outpatients participated in our study. An association was found between the metabolic syndrome (MetS) and memory impairment on measures of verbal learning, and short- and long-term memory. Among the different components of MeTS, hypertriglycerides, abdominal obesity, and low HDL cholesterol were the only factors associated with memory impairment. Alcohol dependence or abuse was associated with a higher rate of forgetting. Conclusion. Our findings suggest that MetS and alcohol use may be linked with memory impairment in schizophrenia. These findings provide important insights into the interdependencies of cardiovascular risk factors and cognitive disorders and support novel strategies for treating and preventing cognitive disorders in patients with schizophrenia.

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Section: Discussioncontrasting

confidence: 99%

Are Cardiovascular Risk Factors Associated with Verbal Learning and Memory Impairment in Patients with Schizophrenia? A Cross-Sectional Study

Lançon

Dassa

Fernandez

et al. 2012

Cardiovascular Psychiatry and Neurology

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“…Our findings showed similar results and magnitude confirming previous studies of the association between MetS and lower cognitive performance [21][22][23][24] , and extend these findings to a predominantly Hispanic population in which the MetS prevalence is high. Hispanics have been traditionally understudied, although they are the fastest growing population in the US, they have the highest MetS prevalence, and together with non-Hispanic blacks, may be at a higher risk of dementia than non-Hispanic whites [25] .…”

Section: Discussionsupporting

confidence: 81%

The Metabolic Syndrome and Cognitive Performance: The Northern Manhattan Study

et al. 2011

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Background: The metabolic syndrome (MetS) is a risk factor for diabetes, stroke, myocardial infarction, and increased mortality, and has been associated with cognition in some populations. We hypothesized that MetS would be associated with lower Mini-Mental State Examination (MMSE) scores in a multi-ethnic population, and that MetS is a better predictor of cognition than its individual components or diabetes. Methods: We conducted a cross-sectional analysis among 3,150 stroke-free participants. MetS was defined by the modified National Cholesterol Education Program guidelines-Adult Treatment Panel III (NCEP-ATPIII) criteria. Linear regression and polytomous logistic regression estimated the association between MMSE score and MetS, its individual components, diabetes, and inflammatory biomarkers. Results: MetS was inversely associated with MMSE score (unadjusted β = –0.67; 95% CI –0.92, –0.41). Adjusting for potential confounders, MetS was associated with lower MMSE score (adjusted β = –0.24; 95% CI –0.47, –0.01), but its individual components and diabetes were not. Those with MetS were more likely to have an MMSE score of <18 than a score of ≧24 (adjusted OR = 1.94; 95% CI 1.26, 3.01). There was an interaction between MetS and race-ethnicity, such that MetS was associated with lower MMSE score among non-Hispanic whites and Hispanics but not non-Hispanic blacks. Conclusions: MetS was associated with lower cognition in a multi-ethnic population. Further studies of the effect of MetS on cognition are warranted, and should account for demographic differences.

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“…Our findings add to a growing body of evidence that suggests MetS is associated with accelerated cognitive aging and the risk of cognitive impairment in acute cerebral ischemia patients, independently of other known risk factors for cognitive impairment (OR 3.542; 95% CI:1.972–6.361, Table 4). This correlation is consistent with the findings of other studies in Chinese populations [5, 6, 24]. However, the overall prevalence of MetS in the present study was 39.3%, which differed from values reported for other Chinese population-based studies [5, 6, 24].…”

Section: Discussionsupporting

confidence: 90%

“…This correlation is consistent with the findings of other studies in Chinese populations [5, 6, 24]. However, the overall prevalence of MetS in the present study was 39.3%, which differed from values reported for other Chinese population-based studies [5, 6, 24]. This discrepancy may be explained by differences in the characteristics of the study populations.…”

Section: Discussionsupporting

confidence: 88%

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Association between Metabolic Syndrome and Cognitive Impairment after Acute Ischemic Stroke: A Cross-Sectional Study in a Chinese Population

et al. 2016

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Background and ObjectivesMetabolic syndrome (MetS), a risk factor for many vascular conditions, is associated with vascular cognitive disorders. The objective of the present study was to explore the associations of MetS and its individual components with the risks of cognitive impairment and neurological dysfunction in patients after acute stroke.MethodsThis cross-sectional study enrolled 840 patients ranging in age from 53 to 89 years from the Tianjin area of North China. Cognitive function was evaluated using the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination. Neuropsychiatric behavior was assessed using the Neuropsychiatric Inventory Questionnaire. Emotional state was examined according to the Hamilton Depression Rating Scale, and neuromotor function was evaluated using the National Institutes of Health Stroke Scale, Barthel index, and the Activity of Daily Living test. After overnight fasting, blood samples were obtained to measure biochemistry indicators.ResultsMetS and its individual components were closely correlated with MoCA score. MetS patients had high levels of inflammation and a 3.542-fold increased odds ratio (OR) for cognitive impairment [95% confidence interval (CI): 1.972–6.361]. Of the individual MetS components, central obesity (OR 3.039; 95% CI: 1.839–5.023), high fasting plasma glucose (OR 1.915; 95% CI: 1.016–3.607), and type 2 diabetes (OR 2.241; 95% CI: 1.630–3.081) were associated with an increased incidence of cognitive impairment. Consistent and significant worsening in different neurological domains was observed with greater numbers of MetS components.ConclusionsMetS was associated with worse cognitive function, neuromotor dysfunction, and neuropsychological symptoms among Chinese acute stroke patients.

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Metabolic syndrome and cognitive impairment amongst elderly people in Chinese population: a cross‐sectional study

Abstract: MetS is associated with cognitive impairment amongst elderly people in the Chinese population.

Cited by 22 publications

References 36 publications

Are Cardiovascular Risk Factors Associated with Verbal Learning and Memory Impairment in Patients with Schizophrenia? A Cross-Sectional Study

Are Cardiovascular Risk Factors Associated with Verbal Learning and Memory Impairment in Patients with Schizophrenia? A Cross-Sectional Study

The Metabolic Syndrome and Cognitive Performance: The Northern Manhattan Study

Association between Metabolic Syndrome and Cognitive Impairment after Acute Ischemic Stroke: A Cross-Sectional Study in a Chinese Population

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