Metabolic syndrome and depressive symptoms among rural Northeast general population in China

Yu, Shasha; Yang, Hongmei; Guo, Xiaokui; Zheng, Liqiang; Sun, Yingxian

doi:10.1186/s12889-016-3913-0

Cited by 21 publications

(24 citation statements)

References 32 publications

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“…No significant differences were found in most of the clinical characteristics, including age and gender, suggesting that our comparisons were reasonable. Hypertension is reportedly more prevalent in patients with PD (Hsu et al, 2015 ) and patients with depression (Yu et al, 2017 ), whereas patients with PDD in our research suffered less hypertension. According to a research from South Korea (Park et al, 2016 ), the incidence of hypertension is not significantly different between patients with PD with and without depression.…”

Section: Discussioncontrasting

confidence: 42%

“…Decreased blood pressure in patients with PDD probably appears as the disease progresses. Serum lipid levels (triglyceride, Yu et al, 2017 , LDL-C, Persons and Fiedorowicz, 2016 , and high-density lipoprotein cholesterol, Ong et al, 2016 ) are also reportedly associated with depressive symptoms and suicidality (Oh and Kim, 2017 ). Here, we have demonstrated significantly lower serum LDL-C and Apo-B levels in patients with PDD for the first time, indicating that altered lipid metabolism is also associated with PDD.…”

Section: Discussionmentioning

confidence: 99%

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Integrated Analysis Reveals Altered Lipid and Glucose Metabolism and Identifies NOTCH2 as a Biomarker for Parkinson's Disease Related Depression

Dong

Feng

et al. 2018

Front. Mol. Neurosci.

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Depression is a common comorbidity in Parkinson's disease (PD) but is underdiagnosed. We aim to investigate the altered metabolic pathways of Parkinson's disease-related depression (PDD) in plasma and to identify potential biomarkers for clinical diagnosis. Consecutive patients with PD were recruited, clinically assessed, and patients with PDD identified. Fasting plasma samples were collected from 99 patients and differentially expressed metabolites and proteins between patients with PDD and PD were identified using non-targeted liquid chromatography-mass spectrometry (LC-MS)-based metabolomics and tandem mass tag (TMT)-based proteomics analysis, followed by an integrated analysis. Based on the above results, enzyme-linked immune sorbent assay (ELISA) tests were then performed to identify potential biomarkers for PDD. In clinics, patients with PDD suffered less hypertension and had lower serum low-density lipoprotein cholesterol and apolipoprotein B levels when compared to the other patients with PD. A total of 85 differentially expressed metabolites were identified in metabolomics analysis. These metabolites were mainly lipids and lipid-like molecules, involved in lipid and glucose metabolic pathways. According to proteomics analysis, 17 differentially expressed proteins were identified, and 12 metabolic pathways were enriched, which were predominantly related to glucose metabolism. Integrated analysis indicated that altered lipid and glucose metabolism in PDD may induce cellular injury through oxidative stress. Additionally, plasma levels of several proteins were confirmed to be significantly altered and correlated with depressive severity. NOTCH2 may be a potential blood biomarker for PDD, with an optimal cut-off point of 0.91 ng/ml, a sensitivity value of 95.65%, and a specificity value of 81.58%. Depressive symptoms are associated with lipid and glucose metabolism in patients with PD and NOTCH2 may be a potential blood biomarker for the clinical diagnosis of PDD.

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Section: Discussioncontrasting

confidence: 42%

Section: Discussionmentioning

confidence: 99%

Integrated Analysis Reveals Altered Lipid and Glucose Metabolism and Identifies NOTCH2 as a Biomarker for Parkinson's Disease Related Depression

Dong

Feng

et al. 2018

Front. Mol. Neurosci.

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“…Measurement invariance has been little studied in the Patient Health Questionnaire-9 (PHQ-9) [11], a self-administered version of PRIME-MD for common mental disorders that evaluates each of the nine depression criteria from the DSM-IV [12] (these criteria are maintained in the DSM-V). Many population studies on depression have used the PHQ-9 for group comparisons [13, 14]. However, because measurement invariance between groups has not been evaluated in these studies, differences between groups may reflect measurement bias rather than true differences in depression [10].…”

Section: Introductionmentioning

confidence: 99%

Valid group comparisons can be made with the Patient Health Questionnaire (PHQ-9): A measurement invariance study across groups by demographic characteristics

et al. 2019

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ObjectiveAnalyze the measurement invariance and the factor structure of the Patient Health Questionnaire-9 (PHQ-9) in the Peruvian population.MethodSecondary data analysis performed using cross-sectional data from the Health Questionnaire of the Demographic and Health Survey in Peru. Variables of interest were the PHQ-9 and demographic characteristics (sex, age group, level of education, socioeconomic status, marital status, and area of residence). Factor structure was evaluated by standard confirmatory factor analysis (CFA), and measurement invariance by multi-group CFA, using standard goodness-of-fit indices criteria for interpreting results from both CFAs. Analysis of the internal consistency (α and ω) was also pursued.ResultsData from 30,449 study participants were analyzed, 56.7% were women, average age was 40.5 years (standard deviation (SD) = 16.3), 65.9% lived in urban areas, 74.6% were married, and had 9 years of education on average (SD = 4.6). From standard CFA, a one-dimensional model presented the best fit (CFI = 0.936; RMSEA = 0.089; SRMR = 0.039). From multi-group CFA, all progressively restricted models had ΔCFI<0.01 across almost all groups by demographic characteristics. PHQ-9 reliability was optimal (α = ω = 0.87).ConclusionsThe evidence presents support for the one-dimensional model and measurement invariance of the PHQ-9 measure, allowing for reliable comparisons between sex, age groups, education level, socioeconomic status, marital status, and residence area, and recommends its use within the Peruvian population.

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“…A wide range of mental disorders increase the risk of suicidal ideation [ 6 ], also known as suicidal thoughts. Globally, depression contributes significantly to suicidal ideation [ 7 ], which increases the risk of death by suicide [ 8 ]. The estimated number of suicidal deaths related to mental disorders has increased from 138,000 in 1990 to 232,000 in 2010 [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Trained lay health workers reduce common mental disorder symptoms of adults with suicidal ideation in Zimbabwe: a cohort study

Munetsi¹,

Simms

Dzapasi³

et al. 2018

BMC Public Health

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BackgroundSuicidal ideation may lead to deliberate self-harm which increases the risk of death by suicide. Globally, the main cause of deliberate self-harm is depression. The aim of this study was to explore prevalence of, and risk factors for, suicidal ideation among men and women with common mental disorder (CMD) symptoms attending public clinics in Zimbabwe, and to determine whether problem solving therapy delivered by lay health workers can reduce common mental disorder symptoms among people with suicidal ideation, using secondary analysis of a randomised controlled trial.MethodsAt trial enrolment, the Shona Symptom Questionnaire (SSQ) was used to screen for CMD symptoms. In the intervention arm, participants received six problem-solving therapy sessions conducted by trained and supervised lay health workers, while those in the control arm received enhanced usual care. We used multivariate logistic regression to identify risk factors for suicidal ideation at enrolment, and cluster-level logistic regression to compare SSQ scores at endline (6 months follow-up) between trial arms, stratified by suicidal ideation at enrolment.ResultsThere were 573 participants who screened positive for CMD symptoms and 75 (13.1%) reported suicidal ideation at baseline. At baseline, after adjusting for confounders, suicidal ideation was independently associated with being aged over 24, lack of household income (household income yes/no; adjusted odds ratio 0.52 (95% CI 0.29, 0.95); p = 0.03) and with having recently skipped a meal due to lack of food (adjusted odds ratio 3.06 (95% CI 1.81, 5.18); p < 0.001). Participants who reported suicidal ideation at enrolment experienced similar benefit to CMD symptoms from the Friendship Bench intervention (adjusted mean difference − 5.38, 95% CI −7.85, − 2.90; p < 0.001) compared to those who had common mental disorder symptoms but no suicidal ideation (adjusted mean difference − 4.86, 95% CI −5.68, − 4.04; p < 0.001).ConclusionsProblem-solving therapy delivered by trained and supervised lay health workers reduced common mental disorder symptoms among participants with suicidal thoughts who attended primary care facilities in Zimbabwe.Trial registrationpactr.org ldentifier: PACTR201410000876178

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Metabolic syndrome and depressive symptoms among rural Northeast general population in China

Cited by 21 publications

References 32 publications

Integrated Analysis Reveals Altered Lipid and Glucose Metabolism and Identifies NOTCH2 as a Biomarker for Parkinson's Disease Related Depression

Integrated Analysis Reveals Altered Lipid and Glucose Metabolism and Identifies NOTCH2 as a Biomarker for Parkinson's Disease Related Depression

Valid group comparisons can be made with the Patient Health Questionnaire (PHQ-9): A measurement invariance study across groups by demographic characteristics

Trained lay health workers reduce common mental disorder symptoms of adults with suicidal ideation in Zimbabwe: a cohort study

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