Metabolic syndrome and dietary patterns: a systematic review and meta-analysis of observational studies

Rodríguez-Monforte, Míriam; Sánchez, Emília; Barrio, Francisco; Costa, Bernardo; Flores-Mateo, Gemma

doi:10.1007/s00394-016-1305-y

Cited by 174 publications

(155 citation statements)

References 89 publications

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“…Induction of MetS in rodents through HCHF diet has been well-established by previous studies [28,29]. It mimics the dietary habit of the Western population with high consumption of saturated fat and wide use of refined sugar as sweeteners in beverages [36]. In this study, HCHF diet for 16 weeks successfully induced MetS by causing central obesity, high blood pressure, and hypertriglyceridemia in rats, which fulfilled at least three criteria put forward by the harmonized definitions of MetS [1].…”

Section: Discussionmentioning

confidence: 60%

The Beneficial Effects of Stingless Bee Honey from Heterotrigona itama against Metabolic Changes in Rats Fed with High-Carbohydrate and High-Fat Diet

Ramli

Chin

Zarkasi

et al. 2019

IJERPH

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Metabolic syndrome (MetS) is a group of conditions including central obesity, hyperglycemia, dyslipidemia, and hypertension that increases the risk for cardiometabolic diseases. Kelulut honey (KH) produced by stingless honey bees has stronger antioxidant properties compared to other honey types and may be a functional food against MetS. This study aimed to determine the efficacy of KH in preventing metabolic changes in rats with MetS induced by high-carbohydrate and high-fat (HCHF) diet. Male Wistar rats were randomly assigned to the control (C), HCHF diet-induced MetS (S), and MetS supplemented with KH (K) groups. The K group was given KH (1 g/kg/day) for eight weeks. Compared to the control, the S group had significant higher omental fat mass, serum triglyceride, systolic blood pressure, diastolic blood pressures, adipocyte area, and adipocyte perimeter (p < 0.05). KH supplementation significantly prevented these MetS-induced changes at week 16 (p < 0.05). Several compounds, including 4-hydroxyphenyl acetic acid, coumaric and caffeic acids, had been detected via liquid chromatography-mass spectrometry analysis that might contribute to the reversal of these changes. The beneficial effects of KH against MetS-induced rats provide the basis for future KH research to investigate its potential use in humans and its molecular mechanisms in alleviating the disease.

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Section: Discussionmentioning

confidence: 60%

The Beneficial Effects of Stingless Bee Honey from Heterotrigona itama against Metabolic Changes in Rats Fed with High-Carbohydrate and High-Fat Diet

Ramli

Chin

Zarkasi

et al. 2019

IJERPH

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“…Trolox or Vc solution (5-100 µg/mL) were served as positive controls. The results were expressed as the percentage of inhibition in the following Equation (1).…”

Section: Phenolic Compositions Analysis By Hplc-esi-hr-qtof-ms/msmentioning

confidence: 99%

“…Nowadays, incidences of metabolic syndrome-related diseases have rapidly increased all over the world, such as oxidative damage, diabetes, obesity, hypertension, and cardiovascular disease [1]. Food nutritionists have revealed that oxidative stress and high-calorie diets was closely related to the development of chronic disease [2].…”

Section: Introductionmentioning

confidence: 99%

HPLC-ESI-qTOF-MS/MS Characterization, Antioxidant Activities and Inhibitory Ability of Digestive Enzymes with Molecular Docking Analysis of Various Parts of Raspberry (Rubus ideaus L.)

Liu

Qin

et al. 2019

Antioxidants

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The anti-oxidative phenolic compounds in plant extracts possess multiple pharmacological functions. However, the phenolic characterization and in vitro bio-activities in various parts of raspberry (Rubus idaeus L.) have not been investigated systematically. In the present study, the phenolic profiles of leaves (LE), fruit pulp (FPE), and seed extracts (SE) in raspberry were analyzed by HR-HPLC-ESI-qTOF-MS/MS method, and their antioxidant activities and digestive enzymes inhibitory abilities were also investigated. The molecular docking analysis was used to delineate their inhibition mechanisms toward type II diabetes related digestive enzymes. Regardless of LE, FPE, or SE, 50% methanol was the best solvent for extracting high contents of phenolic compounds, followed by 50% ethanol and 100% methanol. The LE of raspberry displayed the highest total phenolic content (TPC) and total flavonoid content (TFC). A total of nineteen phenolic compounds were identified. The quantitative results showed that gallic acid, ellagic acid, and procyanidin C3 were the major constituents in the three extracts. The various parts extracts of raspberry all exhibited the strong antioxidant activities, especially for LE. Moreover, the powerful inhibitory effects of the three extracts against digestive enzymes (α-glucosidase and α-amylase) were observed. The major phenolic compounds of the three extracts also showed good inhibitory activities of digestive enzyme in a dose-dependent manner. The underlying inhibitory mechanisms of the main phenolic compounds against digestive enzymes were clarified by molecular docking analysis. The present study demonstrated that the various parts of raspberry had strong antioxidant activities and inhibitory effects on digestive enzymes, and can potentially prevent oxidative damage or diabetes-related problems.

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“…Insulin resistance (IR) is the main pathologic characteristic of MetS and the most accepted unifying theory explaining the pathophysiology of the disease. 1 In the search for improved and novel therapeutic strategies, microRNAs (miRNAs) have drawn attention as potential targets due to their regulatory role on gene networks involved in metabolism, including lipid and glucose homeostasis. 2 Mounting evidence suggests that circulating miRNAs are involved in the regulation of obesity, diabetes, and MetS, but existing studies have yielded inconclusive results.…”

Section: Introductionmentioning

confidence: 99%

Circulating miR-143-3p inhibition protects against insulin resistance in Metabolic Syndrome via targeting of the insulin-like growth factor 2 receptor

Lin

Shengjie

Gui

et al. 2019

Translational Research

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Metabolic syndrome (MetS) is characterized by a cluster of metabolic disorders including obesity, dyslipidemia, hyperglycemia, and hypertension. Here, we report that 27 microRNAs were found to be expressed differently in serum and urine samples of MetS patients compared to control subjects on microarray analysis. Further qualitative real time-polymerase chain reaction analyses confirmed that circulating levels of miR-143-3p were significantly elevated in MetS patients compared with controls, both in serum and urine samples. After accounting for confounding factors, high levels of miR-143-3p remained an independent risk factor for insulin resistance. Inhibition of miR-143-3p expression in mice protected against development of obesity-associated insulin resistance. Furthermore, we demonstrated that insulin-like growth factor 2 receptor (IGF2R) was among the target genes of miR-143-3p by searching 3 widely used bioinformatics databases and preliminary validation. Our experiments suggest that knockdown of circulating miR-143-3p may protect against insulin resistance in the setting of MetS via targeting of IGF2R and activation of the insulin signaling pathway. Our results characterize the miR-143-3p-IGF2R pathway as a potential target for the treatment of obesity-associated insulin resistance.

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Metabolic syndrome and dietary patterns: a systematic review and meta-analysis of observational studies

Cited by 174 publications

References 89 publications

The Beneficial Effects of Stingless Bee Honey from Heterotrigona itama against Metabolic Changes in Rats Fed with High-Carbohydrate and High-Fat Diet

The Beneficial Effects of Stingless Bee Honey from Heterotrigona itama against Metabolic Changes in Rats Fed with High-Carbohydrate and High-Fat Diet

HPLC-ESI-qTOF-MS/MS Characterization, Antioxidant Activities and Inhibitory Ability of Digestive Enzymes with Molecular Docking Analysis of Various Parts of Raspberry (Rubus ideaus L.)

Circulating miR-143-3p inhibition protects against insulin resistance in Metabolic Syndrome via targeting of the insulin-like growth factor 2 receptor

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