Metabolic syndrome and exaggerated blood pressure response to exercise in newly diagnosed hypertensive patients

Abstract

Presence of MS in newly diagnosed hypertensive patients is associated with increased peak exercise BP and a higher frequency of EBPR over and above its separate elements.

Mechanical and metabolic reflex activation of the sympathetic nervous system in younger adults with metabolic syndrome

“…These discrepancies may be due, at least in part, to the presence and/or absence of overt MetSyn. Consistent with this concept, the individual components of the MetSyn fail to predict exaggerated blood pressure responses to whole-body exercise independent of the presence of MetSyn (Miyai et al, 2013; Tsioufis et al, 2012). To investigate potential mechanisms underlying exaggerated blood pressure responses to whole-body exercise in MetSyn, we tested the hypothesis that young adults with MetSyn would exhibit augmented sympathetic and pressor responses to mechanoreflex and metaboreflex activation when compared with healthy, age-matched control subjects.…”

“…Based on reports of exaggerated blood pressure responses to whole-body exercise in patients with metabolic syndrome (Miyai et al, 2013; Tsioufis et al, 2012), we tested the hypothesis that MetSyn adults would exhibit augmented sympathetic and pressor responses to mechanoreflex and metaboreflex activation when compared with healthy, age-matched control subjects. Contrary to our hypothesis, sympathetic and pressor responses to mechanoreflex and metaboreflex activation are not augmented in younger adults with MetSyn.…”

“…Based on reports of exaggerated blood pressure responses to exercise in patients with metabolic syndrome (MetSyn) (Miyai et al, 2013; Tsioufis et al, 2012), it is reasonable to speculate sympathetic nervous system activation during metabo- and mechanoreflex stimulation might be exaggerated as well. This augmented pressor response, if present, could negate the beneficial effects of exercise in this population, for whom exercise is recommended as a non-pharmacological strategy for improving fitness and reducing cardiovascular risk.…”

Predictors for diagnosing metabolic syndrome among hypertensive patients in a tertiary care centre

“…However, some authors reported it as low as 29-35% [5,6]. This variation in prevalence of MS can be explained by different factors like ethnicity, age, gender distribution, duration of hypertension, sample size, type of study and criteria used.…”

“…So, it is important to know the proportion of hypertensive subjects having metabolic syndrome (MS). The prevalence of MS varies from 29% to 68% among hypertensive patients in different studies [3][4][5][6]. As a resource poor country, it may not be possible to screen all hypertensive subjects for the presence of MS.…”