Metabolic Syndrome and Hypertension Resulting from Fructose Enriched Diet in Wistar Rats

Dupas, Julie; Feray, Annie; Goanvec, Christelle; Guernec, Anthony; Samson, Nolwenn; Bougaran, Pauline; Guerrero, François; Mansourati, Jacques

doi:10.1155/2017/2494067

Cited by 56 publications

(52 citation statements)

References 48 publications

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“…In our study, elevated caloric intake related to fructose overconsumption was not followed by an increase in body mass. Similar findings were reported in some previously published studies [7,[25][26][27], while other authors have reported an increase in body mass [28,29]. These discrepancies could be attributed to differences in experimental settings, such as treatment duration, fructose concentration and the form in which the fructose was consumed (liquid vs. solid food), as well as the age of the experimental animals.…”

Section: Controlsupporting

confidence: 87%

“…Some authors have suggested that fructose overconsumption is associated with increased risk of obesity, insulin resistance, metabolic syndrome, type 2 diabetes, cardiovascular disease and nonalcoholic fatty liver disease [1][2][3], with other authors not fully supporting these assertions [4][5][6]. Studies performed on animals have shown that fructose supplementation can result in hypertension, insulin resistance, dyslipidemia and the accumulation of visceral and ectopic fat [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Fructose-enriched diet affects hepatic lipid metabolism in young male and female rats in different ways

Brkljačić

Veličković

Elaković

et al. 2019

Arch biol sci (Beogr)

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An increase in fructose consumption coincides with a rising incidence of metabolic disorders. Dietary fructose has been shown to affect hepatic lipid metabolism in a way that may lead to lipid deposition in the liver. In this study, we tested the hypothesis that the effects of fructose overconsumption on hepatic lipid metabolism differ between sexes. To that end we examined the effects of a high-fructose diet on the expression of key enzymes and transcription factors involved in the regulation of fatty acid oxidation and de novo lipogenesis in the liver of 12-week-old male and female Wistar rats. Immediately after weaning, the rats were subjected to a standard diet and 10% fructose solution or drinking water for 9 weeks. The fructose-enriched diet induced hypertriglyceridemia and increased hepatic de novo lipogenesis in both sexes, without lipid deposition in the liver. At the same time, visceral adiposity was observed only in female rats, while in males the treatment stimulated hepatic fatty acid oxidation. The fructose-enriched diet induced sex-specific effects on hepatic lipid metabolism in young rats. These results imply that male and female rats employ different strategies to cope with dietary fructose-related energy overload and to avoid lipid accumulation in the liver.

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Section: Controlsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Fructose-enriched diet affects hepatic lipid metabolism in young male and female rats in different ways

Brkljačić

Veličković

Elaković

et al. 2019

Arch biol sci (Beogr)

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“…Although diets high in fructose or fat and fructose (HFHF) have been reported to increase fBGLs in male rats at 3 and 8 weeks (Dupas et al, 2017;Huang, Chiang, Yao, & Chiang, 2004;Wong et al, 2018), other studies have reported that fBGLs in male rats were unaltered 8 weeks following high-fructose feeding (Sanchez-Lozada et al, 2007) and 16 weeks following high-fat/high-sugar feeding (Gerbaix et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…The effect of a diet high in fat and sugar on fBGLs is not clear. Although diets high in fructose or fat and fructose (HFHF) have been reported to increase fBGLs in male rats at 3 and 8 weeks (Dupas et al, ; Huang, Chiang, Yao, & Chiang, ; Wong et al, ), other studies have reported that fBGLs in male rats were unaltered 8 weeks following high‐fructose feeding (Sanchez‐Lozada et al, ) and 16 weeks following high‐fat/high‐sugar feeding (Gerbaix et al, ). Similarly, we did not observe a significant change in fBGLs in female rats on an HFHF diet.…”

Section: Discussionmentioning

confidence: 99%

A diet high in fat and fructose adversely affects osseointegration of titanium implants in rats

King

Tanaka

Ross

et al. 2019

Clinical & Exp Dental Res

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Objectives Diet‐induced metabolic dysfunction such as type 2 diabetes mellitus increases the risk of implant failure in both dental and orthopaedic settings. We hypothesised that a diet high in fat and fructose would adversely affect peri‐implant bone structure and function including osseointegration. Materials and methods Thirty female Sprague‐Dawley rats were divided into three groups (n = 10), control group (normal chow) and two intervention groups on a high‐fat (60%), high‐fructose (20%; HFHF) diet. Titanium implants were placed in the proximal tibial metaphysis in all groups either before commencing the diet (dHFHF group) or 6 weeks after commencing the diet (HFHF group) and observed for an 8‐week healing period. Fasting blood glucose levels (fBGLs) were measured weekly. Structural and functional features of the peri‐implant bone, including bone‐to‐implant contact (BIC), were analysed post euthanasia using microcomputed tomography, pull‐out tests, and dynamic histomorphometry. Results The fBGLs were unchanged across all groups. Peri‐implant trabecular bone volume was reduced in the HFHF group compared with controls (p = .02). Percentage BIC was reduced in both HFHF group (25.42 ± 3.61) and dHFHF group (28.56 ± 4.07) compared with the control group (43.26 ± 3.58, p < .05) and reflected the lower pull‐out loads required in those groups. Osteoblast activity was reduced in both intervention groups compared with the control group (p < .05). Conclusion The HFHF diet compromised osseointegration regardless of whether the implant was placed before or after the onset of the diet and, despite the absence of elevated fBGLs, confirming that changes in bone cell function affected both the initiation and maintenance of osseointegration independent of blood glucose levels.

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“…The result of case-control research using wistar rats proved that rats were fed with fructose supplementation induced hypertension, insulin resistance, and dyslipidemia. Meanwhile, the rats in the control group did not (Dupas et al, 2017). Other studies proved that excessive fructose intake increases blood pressure in wistar rats of 7 ± 2 mm Hg (SBP) and 5 ± 2 mm Hg (DBP) (Perez et al, 2010).…”

Section: Introductionmentioning

confidence: 92%

Daily Intake of Dietary Sucrose and Sodium Among Elderly People With Hypertension in Different Culture

Anggi

Sri²

2018

IJPHCS

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Background: Excessive intake of dietary sucrose and sodium has negative effect for blood pressure. The cause of hypertension might be different in various region depends on food habit. The study aims to analyze the differences intake of dietary sucrose and sodium among elderly people with hypertension in different culture. Materials and Methods:A cross-sectional study was conducted in Surabaya (East Java) and Sukoharjo (Central Java). The sample size was 62 (31 subjects in each area). Dietary intake was measured using SQ-FFQ and Food Recall. Data was analyzed using independent sample t-test and Person correlation test to analyze the mean different and correlation between sucrose and sodium intake and hypertension severity. Result:The average intake of dietary sucrose in Sukoharjo was higher (86.6 ±4.5 g) than Surabaya (59.9 ± 2.9 g), sodium intake in Surabaya was higher (3,137 ±113.2 mg) than Sukoharjo (2,268.9 ± 101 mg). Intake level of both nutrients were statistically different in two regions (p= 0,000). Either sucrose or sodium was correlated with severity of hypertension (r=0.974; p=0.004 and r=0.819; 0=0.019, respectively).Conclusion: Sucrose and sodium intake are different in two regions. It correlates with severity of hypertension among elderly. Hypertension in Central of Java might cause by high sucrose intake, otherwise in East Java might cause by high sodium intake.

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Metabolic Syndrome and Hypertension Resulting from Fructose Enriched Diet in Wistar Rats

Cited by 56 publications

References 48 publications

Fructose-enriched diet affects hepatic lipid metabolism in young male and female rats in different ways

Fructose-enriched diet affects hepatic lipid metabolism in young male and female rats in different ways

A diet high in fat and fructose adversely affects osseointegration of titanium implants in rats

Daily Intake of Dietary Sucrose and Sodium Among Elderly People With Hypertension in Different Culture

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