Metabolic syndrome and incidence of liver and breast cancers in Japan

Osaki, Yoneatsu; Taniguchi, Shin‐ichi; Tahara, Aya; Okamoto, M.; Kishimoto, Takuji

doi:10.1016/j.canep.2011.03.007

Cited by 78 publications

(117 citation statements)

References 30 publications

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“…There is growing epidemiologic evidence indicating that metabolic syndrome increases the risk of breast cancer among postmenopausal women [4–10]. Our findings support findings from the Women’s Health Initiative (WHI) study of postmenopausal women, which indicated that time-dependent metabolic syndrome (any combination of ≥3 components) was positively associated with a 77 % (95 % CI 1.01–3.12) increased rate of breast cancer [5].…”

Section: Discussionsupporting

confidence: 83%

“…Limited epidemiologic evidence suggests that metabolic syndrome may be associated with an increased breast cancer risk, particularly among postmenopausal women [4–10]. Individual cardiometabolic factors, such as abdominal obesity, type 2 diabetes, high blood pressure, and high cholesterol, have been associated with increased risks of breast cancer in some studies [4–6, 11–22], but not in others [5, 7, 23–25].…”

Section: Introductionmentioning

confidence: 99%

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Cardiometabolic factors and breast cancer risk in U.S. black women

Bosco

Palmer

Boggs

et al. 2012

Breast Cancer Res Treat

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Previous studies have suggested that metabolic syndrome may be associated with an increased risk of breast cancer, particularly in postmenopausal women, but U.S. black women have not been assessed. We examined the associations of abdominal obesity, type 2 diabetes, hypertension, and high cholesterol individually and in combination with breast cancer incidence in the Black Women’s Health Study. By means of Cox regression models, we estimated incidence rate ratios (IRR) and 95 % confidence intervals (CI) for the associations of baseline and time-dependent values of self-reported abdominal obesity, type 2 diabetes, hypertension, and high cholesterol with breast cancer incidence. During 516,452 person years of follow-up (mean years = 10.5; standard deviation = 2.9) from 1995 to 2007, 1,228 breast cancer cases were identified. After adjustment for age, education, body mass index at age 18, physical activity, and individual cardiometabolic factors, neither individual nor combinations of cardiometabolic factors were associated with breast cancer incidence overall; the multivariable IRR was 1.04 (95 % CI 0.86–1.25) for the combination of ≥3 factors relative to the absence of all factors, and 1.17 (0.85–1.60) for having all four factors. Among postmenopausal women, however, the comparable IRRs were 1.23 (0.93–1.62) and 1.63 (1.12–2.37), respectively. Our findings provide some support for an association between cardiometabolic factors and breast cancer incidence among postmenopausal U.S. black women.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Cardiometabolic factors and breast cancer risk in U.S. black women

Bosco

Palmer

Boggs

et al. 2012

Breast Cancer Res Treat

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“…One study was identified via hand searching and the study was included in our meta-analysis. Thus, the meta-analysis included 30 independent observational studies89101112131415161718192021222324252627282930313233343536 published between 1989 and 2016 with a total of 11643 breast cancer cases. The characteristics of the included studies were summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Hypertension and breast cancer risk: a systematic review and meta-analysis

Han

Guo

Shi

et al. 2017

Sci Rep

173

104

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Observational studies examining the relationship between hypertension and breast cancer risk have reported conflicting findings. We conducted this systematic review and meta-analysis to summarize the evidence regarding the association between hypertension and risk of breast cancer. Eligible studies were identified through a comprehensive literature search of PubMed, EMBASE, and the Cochrane library until August 2016. We included observational studies that reported relative risks (RR) with corresponding 95% confidence intervals (CIs). Results from individual studies were pooled by using a random-effects model. 29 articles of 30 studies, with totally 11643 cases of breast cancer, were eligible for inclusion in the meta-analysis. We observed a statistically significant association between hypertension and increased breast cancer risk (RR: 1.15; 95% CI: 1.08, 1.22). In the subgroup analysis, we found a positive association between hypertension and breast cancer incidence among postmenopausal women (RR: 1.20; 95% CI: 1.09, 1.31). In contrast, hypertension was not associated with risk of breast cancer among premenopausal women (RR: 0.97; 95% CI: 0.84, 1.12) and Asian population (RR: 1.07; 95% CI: 0.94, 1.22).This meta-analysis collectively suggests a significantly association between hypertension and breast cancer risk, specifically for postmenopausal hypertensive women.

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“…According to the recent publication in Japan, an estimated 10.7 million people suffered from MetS and another 9.4 million were estimated to be at risk in 2006 [3]. MetS is strongly associated with the development of cardiovascular disease (CVD), coronary heart disease (CHD), and diabetes mellitus [4,5], and has been found to be related to colon and breast cancers [6,7]. Thus, finding preventive measures for this syndrome is a matter of great importance.…”

Section: Introductionmentioning

confidence: 99%