Metabolic Syndrome and Insulin resistance: Etiopathegenesis and influencing factors

Al-Mahmood, AK; Afrin, SF; Hoque, Nazmul

doi:10.3329/bjmb.v4i2.13773

Cited by 4 publications

(4 citation statements)

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“…The metabolic syndrome (MetS),as comprised of visceral obesity, dyslipidaemia, hyperglycaemia, and hypertension, has become one of the major challenges in clinical medicine as well as in publichealthworldwide [1][2][3] .MetS is a cluster of interrelated risk factors whichshows higher susceptibilityto cardiovascular disease (CVD) by 2-fold increase of risk and type 2 diabetes mellitusby 5-fold 4 and that tends to come to an effect within 5-10 years spanin an apparently healthy individual 5 -as itis evident that subjectively healthy individuals may have biochemical abnormalities along with presence of MetS 6,7 . The identification ofmodifiable CVD risk factors and predictors of MetS inan otherwise healthy population is necessary in order toidentify individuals who may benefit from early interventions 6 .…”

Section: Introductionmentioning

confidence: 99%

Triglycerides and Glucose Index as Potential Marker of Metabolic Syndrome

Tabassum

Mozaffor

Rahman

et al. 2020

Int. J. Hum. Health Sci.

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Background:Triglycerides and Glucose Index (TyG index), a product from fasting levels of triglycerides and glucose, presented promising results as apotential marker of metabolic syndrome in different ethnicity. However, no such reports are available in our population to date.Objective: To see the effectiveness of ‘Triglycerides and Glucose Index’ to predict metabolic syndromein a Bangladeshi population.Methods: This cross-sectional study was carried out in Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, from March 2016 to February 2017. A total of 200 apparently healthy subjects (127 men and 73 women) were selected for the study, who attended the out-patient-departments of the same institution. Anthropometric measurements were recorded – height, weight, waist circumference (WC) and body mass index (BMI). Overnight fasting blood samples were collected to estimate fasting serum glucose andlipid profile. Then TyG index was calculated and evaluated as a tool in diagnosis of metabolic syndrome in the study subjects.Receiver operating characteristic (ROC) curves were plotted to assess the performance of TyG index in MetS prediction by gender. The power of MetS prediction was quantified by the area under the curve (AUC) with 95% confidence intervals.Results: Sensitivity, specificity, positive predictive value and negative predictive value of TyG index to predict metabolic syndrome were 70.45%, 82.14%, 75.61% and 77.97%in males and 25.00%, 97.32%, 88.00% and 62.29%in females respectively. ROC curve showed optimal cut off value 8.72 and area under the curve 0.72 in male study subjects; in female study subjects, the values were 8.72 and 0.96 respectively (P<0.001).Conclusion:Triglycerides and Glucose Index (TyG index) represents a simple,accessible and effective tool for assessment of metabolic syndrome in Bangladeshi population.International Journal of Human and Health Sciences Vol. 05 No. 01 January’21 Page: 85-89

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Section: Introductionmentioning

confidence: 99%

Triglycerides and Glucose Index as Potential Marker of Metabolic Syndrome

Tabassum

Mozaffor

Rahman

et al. 2020

Int. J. Hum. Health Sci.

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“…Menopause is accompanied with a redistribution of body fat resulting in central obesity and insulin resistance which were found to largely increase the prevalence of MetS in postmenopausal females 30 . Additionally, several biological changes take place during menopause and might aid indeveloping insulin resistance and MetS including oxidative stress, inflammatory changes, and postmenopausal alterations in adipocytokine production and lipid utilization 31,32 . These facts broadly elucidate the obvious acceleration in cardiovascular diseases (CVD) in females post menopause 33 .…”

Section: Resultsmentioning

confidence: 99%

Gender Differentials of Metabolic Syndrome in Bangladesh taking Menopause into Consideration

Billah

Jahan

Jundi

et al. 2020

Int. J. Hum. Health Sci.

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Objective:To assess the gender differences of metabolic syndrome (MetS) in Bangladesh and factors associated with it.Materials and methods: Cross sectional study was performed on 227 premenopausal women, 48 menopausal women and 217 men. The gender differentials were studied with measurement of waist circumference, blood pressure and fasting blood for triglyceride (TG), high density lipoprotein (HDL), blood sugar (FBS).Results:Premenopausal women had 22.9% (95% CI: 17.9-28.8%), menopausal women had 43.8% (95% CI: 30.7-57.7%), and the men had 53.9% (95% CI: 47.3-60.4%) prevalence of MetS giving a 1:1.7:2.1 ratio of premenopausal, menopausal women and men prevalence respectively. More than 95% of study population had low HDL irrespective of gender and menopause status. Obesity was 5.3% in premenopausal women, 14.6% in menopausal women and 54.4% in men. HTN was 10.6% in premenopausal women, 35.4% in menopausal women, and 19.4% in men. High TG was 42.5% in premenopausal women, 41.7%, in menopausal women and 62.0% in men. High FBS was 22.0% in premenopausal women, 37.5% in menopausal women and 30.4% in men.Conclusion: Compared to premenopausal women, MetS in men was two times higher and nearly two times higher in menopausal women, pulling menopausal women prevalence almost equal to men. Menopausal women had high prevalence of HTN while obesity was more prevalent in men. Dyslipidemia should be a concern for the policy makers in search of a prevention program.International Journal of Human and Health Sciences Vol. 05 No. 01 January’21 Page: 101-107

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“…Several other studies also emphasized that utilization of fruits as compare to juices are associated with a lower risk of diabetes, especially among women 24,25,26 . A meta-analysis showed that fruit juice has a borderline significant effect on reducing diastolic blood pressure, but had no effect on systolic blood pressure 27,28 .…”

Section: Introductionmentioning

confidence: 99%

Possible role of grape fruit in controlling hyperglycemia and associated complications: Better glycemic control in healthy subjects through fruits fibers as compared to fruit juices

Gul

Khatoon

Ahmed

et al. 2020

Bangladesh J Med Sci

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Background: Diabetes is regarded as a chronic disorder, which is globally spreading at an alarming rate and individuals are being pushed down by the burden of diabetes. Different measures and control programs have been conducted for awareness of this disaster endocrine disease as its associated complications. Objective: Current study has been conducted to evaluate the hypothesis that whole fruits provide better glycemic control than fruit juices. Materials & Methods: The study includes two groups of healthy volunteers, one group was on whole fruits while another group was supplied with fruit juices of same fruits and fasting blood sugar and random blood sugar were monitored. Results: Results revealed that whole grapefruit and orange fruit play effective role in maintaining random blood sugar levels in comparison to juices. Further suggested that dietary fibers are not only effective in regulating blood sugar, but also influence on blood pressure and pulse rate. Conclusion: Based on above findings, it has been concluded that type 2 diabetes patients can achieve better glycemic control by dietary fibers rather than juices, and it may be helpful in controlling diabetes related complication such as high blood pressure. Bangladesh Journal of Medical Science Vol.19(3) 2020 p.480-485

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Metabolic Syndrome and Insulin resistance: Etiopathegenesis and influencing factors

Cited by 4 publications

References 50 publications

Triglycerides and Glucose Index as Potential Marker of Metabolic Syndrome

Triglycerides and Glucose Index as Potential Marker of Metabolic Syndrome

Gender Differentials of Metabolic Syndrome in Bangladesh taking Menopause into Consideration

Possible role of grape fruit in controlling hyperglycemia and associated complications: Better glycemic control in healthy subjects through fruits fibers as compared to fruit juices

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