Metabolic syndrome and insulin signaling in kidney

Abstract

Metabolic syndrome (MetS) is now recognized as a big threat for human health. It has been a problem in developed countries for decades and also emerging similarly in developing countries. It has been also called as "Syndrome X", "Deadly quartet", "Reaven's syndrome". Essentially these are of the same clinical status, in which insulin resistance is the common condition. In such condition hyperinsulinemia occurs, which may have potential influence on other organs and tissues, including kidney -glomeruli and tubules -, cardiovascular systems, liver, muscles. This review will focus on the influence of MetS on the point of insulin resistance and its influence of kidney, especially proximal tubules and glomeruli.

Late Stage Complications of Diabetes and Insulin Resistance

“…Metabolic syndrome is predicted to become a major public health problem in many developed, as well as developing countries. It has been referred to as Syndrome X [90] or the Insulin Resistance Syndrome and is currently referred to as the Metabolic Syndrome. Metabolic syndrome (Mets), a complex of disorders including the abdominal obesity, dyslipidemia, hypertension and impaired fasting glucose, is one of the known risk factors for cardiovascular disease (CVD).…”