Metabolic syndrome and its association with white blood cell count in children and adolescents in Korea: The 2005 Korean National Health and Nutrition Examination Survey

Lee, Y.-J.; Shin, Youn Ho; Kim, J.-K.; Shim, Jae Yong; Kang, Dae Ryong; Lee, H.-R.

doi:10.1016/j.numecd.2009.03.017

Cited by 41 publications

(37 citation statements)

References 26 publications

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“…While atherosclerosis-associated inflammation might contribute to this relationship, there is also considerable evidence that leukocytosis directly enhances atherosclerosis and thrombosis (1). Numerous CVD risk factors -including obesity, smoking, sedentary lifestyles and metabolic syndrome (including individual components of metabolic syndrome, such as high triglycerides and low HDL) -are all associated with leukocytosis (2)(3)(4). While these associations have usually been made for total wbcs or neutrophils, monocytosis has also been specifically associated with CVD and with atherosclerotic plaque burden in both prospective and cross-sectional studies (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice

Murphy¹,

Akhtari²,

Tolani³

et al. 2011

J. Clin. Invest.

451

532

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Leukocytosis is associated with increased cardiovascular disease risk in humans and develops in hypercholesterolemic atherosclerotic animal models. Leukocytosis is associated with the proliferation of hematopoietic stem and multipotential progenitor cells (HSPCs) in mice with deficiencies of the cholesterol efflux-promoting ABC transporters ABCA1 and ABCG1 in BM cells. Here, we have determined the role of endogenous apolipoprotein-mediated cholesterol efflux pathways in these processes. In Apoe -/-mice fed a chow or Western-type diet, monocytosis and neutrophilia developed in association with the proliferation and expansion of HSPCs in the BM. In contrast, Apoa1 -/-mice showed no monocytosis compared with controls. ApoE was found on the surface of HSPCs, in a proteoglycan-bound pool, where it acted in an ABCA1-and ABCG1-dependent fashion to decrease cell proliferation. Accordingly, competitive BM transplantation experiments showed that ApoE acted cell autonomously to control HSPC proliferation, monocytosis, neutrophilia, and monocyte accumulation in atherosclerotic lesions. Infusion of reconstituted HDL and LXR activator treatment each reduced HSPC proliferation and monocytosis in Apoe -/-mice. These studies suggest a specific role for proteoglycanbound ApoE at the surface of HSPCs to promote cholesterol efflux via ABCA1/ABCG1 and decrease cell proliferation, monocytosis, and atherosclerosis. Although endogenous apoA-I was ineffective, pharmacologic approaches to increasing cholesterol efflux suppressed stem cell proliferative responses.

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Section: Introductionmentioning

confidence: 99%

ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice

Murphy¹,

Akhtari²,

Tolani³

et al. 2011

J. Clin. Invest.

451

532

View full text Add to dashboard Cite

show abstract

“…A mounting body of evidence suggests that CVD is closely linked to chronic low-grade inflammation, which is known to contribute to the development of atherosclerosis [25]. Higher WBC counts and ferritin levels, even within the normal range, have been associated with CVD and MS [26,27], which are conditions linked to chronic low-grade inflammation and insulin resistance. Thus, vitamin D is drawing the interest of medical researchers with its potential role in a wide variety of health conditions, including CVD [28] and insulin resistance [16].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D status and its association with cardiometabolic risk factors in Korean adults based on a 2008-2010 Korean National Health and Nutrition Examination Survey

Chung

Hong

2013

Nutr Res Pract

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Recent studies suggest that vitamin D deficiency and cardiometabolic disorders are becoming increasingly more prevalent across multiple populations. However, there is a lack of comprehensive data for Korean adults. We investigated the vitamin D status, the prevalence of vitamin D deficiency and its association with metabolic syndrome (MS) risk in Korean adults aged 20 years or older. The study subjects (n = 18,305) were individuals who participated in the Korean National Health Examination and Nutrition Survey (KNHANES) in 2008-2010. Vitamin D status (25-hydroxyvitamin D [25(OH)D]) was categorized as < 20, 21-29, and ≥ 30 ng/mL, which are the cut-off points for deficiency, insufficiency and normal limits. A wide variety of cardiometabolic risk factors were compared according to the vitamin D status. Vitamin D deficiency was found in 53.9% of men and 70.5% of women. Mean BMI, systolic BP, HbA1c and low density lipoprotein cholesterol (LDL-C) were highest in the vitamin D deficiency group in both genders. Further, the MS was most prevalent in the vitamin D deficiency group in both genders (12.3%, P = 0.002 in men and 9.2%, P < 0.001 in women). Compared to the vitamin D normal group, the adjusted odds ratio (ORs) (95% confidence interval [95% CI]) for MS in the vitamin D deficiency group were 1.46 (1.05-2.02) in men and 1.60 (1.21-2.11) in women, after adjusting for confounding variables. In conclusion, Vitamin D deficiency is a very common health problem in Korean adults and is independently associated with the increasing risk of MS.

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“…At the same time, several other abnormalities, such as microalbuminuria, inflammation markers, and adipocytokines were found to have strong correlations with CVD and diabetes [2,3]. Contrary to the MetS components, these markers are considered to be "non-traditional components" [4][5][6][7][8]. For example, white blood cell (WBC) count was first found to be associated with MetS by Nagasawa et al This is not completely surprising, since WBC itself is a marker of inflammation [9].…”

Section: Introductionmentioning

confidence: 99%

“…This evidence strongly implies an association between hematogram components and chronic inflammation [10][11][12][13][14]. Although a number of studies have been published with younger adults [4][5][6][7][8][9][10][11][12], little is known about the similar relationships between hematogram and MetS components among the elderly.…”

Section: Introductionmentioning

confidence: 99%

Association of complete blood cell counts with metabolic syndrome in an elderly population

Li¹,

Chen²,

Chang³

et al. 2016

Diabetes Research and Clinical Practice

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Metabolic syndrome and its association with white blood cell count in children and adolescents in Korea: The 2005 Korean National Health and Nutrition Examination Survey

Cited by 41 publications

References 26 publications

ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice

ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice

Vitamin D status and its association with cardiometabolic risk factors in Korean adults based on a 2008-2010 Korean National Health and Nutrition Examination Survey

Association of complete blood cell counts with metabolic syndrome in an elderly population

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