Metabolic syndrome and male lower urinary tract symptoms

Ineichen, Gallus B; Burkhard, Fiona C.

doi:10.23736/s0031-0808.21.04496-7

Cited by 5 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, it can provide more ideas for exploring the mechanisms of ageing. Research has suggested that the mechanisms of bladder ageing are complex, with hypoxia, oxidative stress and inflammatory responses playing a role in ageing-associated bladder dysfunction [37][38][39]. However, recent studies have suggested that inflammatory ageing is a significant mechanism for ageing-associated bladder dysfunction [38][39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer

Zhao,

Luo,

Yang

et al. 2024

Immun Ageing

View full text Add to dashboard Cite

Background Research has suggested significant correlations among ageing, immune microenvironment, inflammation and tumours. However, the relationships among ageing, immune microenvironment, cystitis and bladder urothelial carcinoma (BLCA) in the bladder have rarely been reported. Methods Bladder single-cell and transcriptomic data from young and old mice were used for immune landscape analysis. Transcriptome, single-cell and The Cancer Genome Atlas Program datasets of BLCA and interstitial cystitis/bladder pain syndrome (IC/BPS) were used to analyse immune cell infiltration and molecular expression. Bladder tissues from mice, IC/BPS and BLCA were collected to validate the results. Results Eight types of immune cells (macrophages, B-cells, dendritic cells, T-cells, monocytes, natural killer cells, γδ T-cells and ILC2) were identified in the bladder of mice. Aged mice bladder tissues had a significantly higher number of T-cells, γδ T-cells, ILC2 and B-cells than those in the young group (P < 0.05). Three types of T-cells (NK T-cells, γδ T-cells and naïve T-cells) and three types of B-cells (follicular B-cells, plasma and memory B-cells) were identified in aged mice bladder. Chemokine receptor 7 (CCR7) is highly expressed in aged bladder, IC/BPS and BLCA (P < 0.05). CCR7 is likely to be involved in T- and B-cell infiltration in aged bladder, IC/BPS and BLCA. Interestingly, the high CCR7 expression on BLCA cell membranes was a prognostic protective factor. Conclusions In this study, we characterised the expression profiles of immune cells in bladder tissues of aged and young mice and demonstrated that CCR7-mediated T- and B-cell filtration contributes to the development of bladder ageing, IC/BPS and BLCA.

show abstract

Section: Discussionmentioning

confidence: 99%

Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer

Zhao,

Luo,

Yang

et al. 2024

Immun Ageing

View full text Add to dashboard Cite

show abstract

“…На думку більшості фахівців, які вивчали СНСШ у чоловіків молодого віку, найчастіше вони були обумовлені бактеріальним запаленням передміхурової залози, порушенням нормальної функції сечового міхура, а також психогенними факторами [3]. В той же час, у чоловіків молодше 40 років, які страждають на метаболічний синдром, порівняно зі здоровими однолітками були більш високі показники балів за міжнародною шкалою оцінки простатичних симптомів (IPSS) і діагностувався більший об'єм передміхурової залози [4]. Скарги на розлад сечовипускання у пацієнтів цієї групи також необхідно розглядати в контексті наявності факторів ризику розвитку або ознак метаболічного синдрому.…”

Section: лікування захворювань що супроводжуються інфравезикальною об...unclassified

Treatment of Diseases Accompanied by Infravesical Obstruction in Young Men

Nikitin¹,

Reznikovov²

2022

Ukr. ž. med. bìol. sportu

View full text Add to dashboard Cite

The purpose of the work was to study the possibilities of conservative and surgical treatment of infravesical obstruction in young patients with lower urinary tract symptoms. Materials and methods. Urodynamic diagnosis of infravesical obstruction due to increased resistance of the prostatic part of the urethra was established in 36 patients, whose age was 32.76 ± 1.13 years on average. The volume of the prostate gland according to transrectal ultrasound examination varied from 18 to 32 cm3 (on average 24.05 ± 1.28 cm3). Based on the results of a complex urodynamic study, 3 groups were identified: group 1 – 12 (33.3%) patients with infravesical obstruction with low-amplitude detrusor hyperactivity in the filling phase; group 2 – 13 (36.1%) patients with infravesical obstruction without an abdominal component during urination; group 3 – 11 (30.6%) men with infravesical obstruction in the presence of an abdominal component during urination. The control group included 16 men aged 21–48 years (on average 36.32 ± 2.34 years), who had no lower urinary tract symptoms. The effectiveness of drug therapy was assessed by comparing the initial indicators and quality of life indicators after 1 month, the IPSS index, the maximum volumetric rate of urination, and the residual urine volume. Results and discussion. To select the first line of therapy, the data of a complex urodynamic study and other examination methods (tamsulosin 0.4 mg, tamsulosin 0.4 mg + solifenacin 5 mg or tamsulosin 0.4 mg + mirabegron 25 mg) were taken into account. 16 patients who felt improvement after 1 month of drug treatment continued to experience it for 12–18 months. 17 (47.2%) persons out of 36 examined patients underwent surgical intervention due to symptoms of infravesical obstruction: 14 (70.0%) out of 20 – in whom drug therapy did not achieve the expected effect and 3 patients who refused conservative therapy despite its effectiveness. The patients underwent transurethral resection of the prostate gland. 12–18 months after observation, the patients determined a significant improvement in their condition, namely, in all parameters there was no significant difference from the control indicators. Conclusion. The effectiveness of conservative therapy in young men with infravesical obstruction reaches only 44.4%. But in case of improvement from treatment after 1 month, the stable positive effect of this type of treatment remains for 12–18 months. We believe that the main cause of infravesical obstruction in this contingent of patients may be benign prostatic hyperplasia, which debuted at earlier terms. Observation and treatment of this group of patients should be carried out according to the same principles as in patients with a similar pathology of an older age. If conservative therapy is ineffective within 1 month in this contingent of patients, transurethral resection of the prostate gland is indicated. After 12–18 months of observation, the operated patients determined a significant improvement in their condition, namely – in all parameters there was no significant difference from the control indicators. Thus, in case of absence of effectiveness of drug therapy in young male patients with infravesical obstruction, minimally invasive surgical intervention can significantly improve the quality of life, normalize urodynamic indicators, and reduce the IPSS score

show abstract

Correlation of the Components of the Metabolic Syndrome and Prostate Cancer

李

2023

ACM

View full text Add to dashboard Cite

Metabolic syndrome and male lower urinary tract symptoms

Cited by 5 publications

References 41 publications

Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer

Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer

Treatment of Diseases Accompanied by Infravesical Obstruction in Young Men

Correlation of the Components of the Metabolic Syndrome and Prostate Cancer

Contact Info

Product

Resources

About