Metabolic Syndrome and Mammographic Density in Premenopausal Chilean Women

Abstract

Our results showed no association between MetS and ADV; nevertheless, abdominal obesity and triglycerides were related to higher ADV. If MD could be modifiable through nutritional factors, it would open new perspectives for the prevention of breast cancer through obesity prevention strategies at population level.

Association of Mammographic Density and Benign Breast Calcifications Individually or Combined with Hypertension, Diabetes, and Hypercholesterolemia in Women ≥40 Years of Age: A Retrospective Study

“…In another study by the same group, however, no association between BMI-adjusted per cent density and metabolic syndrome or its components was detected in a similar-aged population, apart from HDL-C, which was associated with increased density 10. Conversely, in a study involving 364 premenopausal Chilean women, no association between metabolic syndrome and absolute dense volume was found; however, triglycerides were related to higher absolute dense volume 20. In the largest study to date, involving 73,974 Korean women, metabolic syndrome and its components were associated with dense breasts (MD-D) in premenopausal women, while in both premenopausal and postmenopausal women high blood glucose and insulin resistance were positively associated with dense breasts 22.…”

“…Limited available evidence has focused on the association of MD with the metabolic syndrome cluster10 19-23 rather than individual CVD risk factors. Inconsistencies in the results are noted, likely due to the small number of participants,10 21 24 inclusion of variable age groups (premenopausal,22 postmenopausal,21 or both19), and multiple ethnicities 10 24.…”

“…10 Conversely, in a study involving 364 premenopausal Chilean women, no association between metabolic syndrome and absolute dense volume was found; however, triglycerides were related to higher absolute dense volume. 20 In the largest study to date, involving 73,974 Korean women, metabolic syndrome and its components were associated with dense breasts (MD-D) in premenopausal women, while in both premenopausal and postmenopausal women high blood glucose and insulin resistance were positively associated with dense breasts. 22 Our findings on MD have validity; the distribution of MD categories [25][26][27] in this study and the inverse relation between MD and age and BMI 25 27-29 are consistent with the available literature.…”