Metabolic Syndrome and Migraine

Sachdev, Amit; Marmura, Michael J.

doi:10.3389/fneur.2012.00161

Cited by 39 publications

(36 citation statements)

References 152 publications

(149 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Migraineurs are much more likely to have metabolic disorders than non-migraineurs [23][24][25][26][27][28][29] which we speculated is connected to carbohydrate disturbance of electrolytes [30]. Additionally, migraineurs have only nominal changes in voltage between states of action potential versus resting potential, indicating that a migraine brain is "always on," [31,32] supporting the theory that migraineurs have hyper sensitive sensory organs [33,34].…”

Section: Introductionmentioning

confidence: 56%

Migraine Cause And Treatment

Stanton¹

2015

Ment Health Fam Med

View full text Add to dashboard Cite

Background:Research shows that migraine brains have hyperactive sensory organs and multiple sensory receptor connections. Hyper activity of these organs needs extra supply of nutrition to support increased electrical activity. Today's medicines reduce or prevent the functioning of these neurons by blocking essential voltage dependent calcium or sodium channel instead of providing nutrients. We asked: if we provide support for extra electrical activity of migraineurs, would it prevent migraines without the use of medicines? Methods:We reviewed published literature and conducted research over 6 months studying 650 volunteer migraineurs in a migraine-research Facebook group. Participants were screened for migraine types, answered a questionnaire on medical conditions, medicines used, and lifestyle. They were provided instructions on the use of the migraine protocol and were evaluated weekly. Findings:Migraine frequency appears to be exacerbated by carbohydrate-rich and salt-and water-poor diets and may be worsened by medicines that block voltage gated calcium or sodium channels. Stopping these medicines, reducing carbohydrates and increasing saline in electrolytes appears to prevent and/or stop migraines.Conclusions: H 2 O and Na+ efflux from cells caused by glucose, electrolyte mineral (Na+, Cl-, K+) ratio may be disrupted in carbohydrate heavy diets causing migraines. Changes to diet that include increased salt intake along with reduced carbohydrate intake appears to prevent glucose induced electrolyte changes which then decreases migraine frequency. In the present study, all participants who made these dietary changes were able to eliminate migraine medications and remained migraine free.

show abstract

Section: Introductionmentioning

confidence: 56%

Migraine Cause And Treatment

Stanton¹

2015

Ment Health Fam Med

View full text Add to dashboard Cite

show abstract

“…Bu sitokinler (IL-6, TNF-alfa) düşük seviyede inflamasyon ve protrombik duruma neden olur. Artan sempatik aktivasyon primer baş ağrılarının gelişmesinde bir faktör olarak karşımıza çıkar (13)(14)(15)(16) . Migrende öne sürülen mekanizmalar kortikal irritabilite, nöronal sistem inflamasyonu ve vasküler endotelyal disfonksiyondur (17) .…”

Section: Discussionunclassified

Headache in hyperlipidemia patients

Baş¹,

Demirci²,

Arslan³

et al. 2015

Terh

View full text Add to dashboard Cite

ÖZETAmaç: Baş ağrısı, genel polikliniklere en sık başvuru nedenlerdendir. Son yıllarda metabolik sendrom, obezite ve primer baş ağrıları arasındaki ilişki dikkati çekmekte-dir. Amacımız hiperlipidemi ve baş ağrısı arasındaki ilişkiyi araştırmaktadır. Yöntemler: Lipid düzeyleri ölçülerek uluslararası kolesterol eğitim programı erişkin tedavi paneli III (NCEP ATP III) kriterlerine göre hiperlipidemi tanısı alan 92 kişi ve sağlıklı 100 kişi çalışmaya dâhil edildi. Tüm kişilerde baş ağrısının varlığı, süresi, sıklığı, atak süresi ve ağrının şiddeti araştırıldı. Bulgular: Katılımcıların yaş ortalamaları 37±13,8 yıldı. Yüz altısı (%55,2) kadın, 86'sı (%44,8) erkekti. İki grup yaş ve cinsiyet olarak benzerdi. Hiperlipidemi grubunda, 30 (%32,6) kontrol grubunda 16 (%16,0) kişide baş ağrısı tespit edildi. Hiperlipidemi grubunda baş ağrısı varlığı istatistiksel olarak anlamlı şekilde yüksekti (p=0.04). Baş ağrısı tipleri arasında anlamlı fark yoktu (p=0,9). Hiperlipidemili hastalarda atak şiddeti ve atak süresi kontrole göre daha yüksek bulundu (p=0,003, p=0,04). Sonuç: Çalışmamız hiperlipidemili hastalarda baş ağrısının sık olabileceğini göster-mektedir. Bu nedenle klinisyenler hiperlipidemili hastalarda baş ağrısının farkında olmalıdır.Anahtar kelimeler: Baş ağrısı, hiperlipidemi, migren ABSTRACT Objective: Headache is the most common complaint of the patients, who applied to general outpatient clinics. In recent years, association between metabolic syndrome, obesity, and primary headaches has attracted much attention. Our aim was to investigate the association between headache and hyperlipidemia. Methods: Ninety-two participants with hyperlipidemia and 100 healthy controls were enrolled in this study. The diagnosis of hyperlipidemia was made according to National Cholesterol Education Program Adult Treatment Panel III criteria. We investigated the presence, duration, frequency, severity of headache, the duration of headache attack. Results: Mean age of the participants was 37±13.8 years. Of all participiants, 106 (55.2%) were females, 86 (44.8%) were males. Two groups were similar in terms of gender and age. In the hyperlipidemia group, 30 (32.6%) patients had headache, and in the control group 16 (16.0%) cases had headache. This difference was statistically significant (p=0.04). There was no statistically significant difference between the groups according to the type of headache (p=0.9). The patients with hyperlipidemia had significantly higher VAS and prolonged headache attacks compared to the controls (p=0.003, p=0.04). Conclusions: Our study suggests that headache may be frequent in hyperlipidemia patients. Therefore, clinicans should be aware of headache in hyperlipidemia patients. Araşt. Hast. Dergisi 2015; 25(3):186-190 doi:10.5222/terh.2015.186 Gİrİş Baş ağrısı, nöroloji ve genel polikliniklere başvu-ran hastaların en sık başvuru nedenlerinden biridir. Ülkemizde baş ağrısı nedeni ile doktora başvuru oranı %38,9 olup, bu oran kadınlarda %46,1, erkek-

show abstract

“…Ассоциация мигрени, ожирения и метаболического синдрома активно обсуждается в меди-цинской литературе. Показано, что пациенты с мигренью часто имеют множественные метаболические нарушения, включающие инсулинорезистентность, снижение выра-ботки адипонектина, дислипидемию и висцеральное ожирение, но в отличие от артериальной гипертензии развитие ожирения у пациентов с мигренью является важным фактором риска трансформации эпизодической мигрени в хроническую мигрень [20].…”

Section: артериальная гипертензия метаболический синдром и мигреньunclassified

Therapy of Arterial Hypertension and Prevention of Cardiovascular Diseases in Woman of Reproductive Age Suffering From Migraine. Clinical Review

Кисляк¹,

Стародубова²,

Червякова³

2017

Med. sov.

View full text Add to dashboard Cite

С огласно последним доступным европейским статистическим данным, сердечно-сосудистые заболевания (ССЗ) являются причиной более 4 млн смертей в Европе ежегодно, что составляет около 45% всех смертей [1]. Известно, что эффективными мера-ми снижения преждевременной смертности от болезней системы кровообращения являются не только лечение, но также первичная и вторичная профилактика. В связи с этим огромное внимание уделяется выявлению факторов риска (ФР) ССЗ и поражений органов-мишеней (ПОМ) на ранних этапах развития сердечно-сосудистой патологии. Хотя список традиционных ФР CCЗ у мужчин и у женщин одинаков, но многие авторы отмечают, что некоторые из них, прежде всего курение, сахарный диабет 2 типа (СД) и артериальная гипертензия (АГ), у женщин имеют боль-шую значимость, чем у мужчин [2]. У молодых женщин при отсутствии 5 основных ФР (курения, АГ, СД, гиперхо-лестеринемии и избыточной массы тела) коронарная болезнь и другие ССЗ встречаются редко. Но только 20% женщин моложе 40 лет удовлетворяют этим критериям низкого риска, в то время как 48% женщин имеют три или более ФР ССЗ [3].Существуют гендерные различия в структуре сердеч-но-сосудистой заболеваемости и смертности. В течение жизни риск возникновения ССЗ у мужчин выше, чем у женщин [2], но за последние десятилетия эти различия уменьшаются за счет снижения риска у мужчин и повы-шения его у женщин [3]. Более того, в настоящее время в Европе количество смертей женщин от ССЗ выше у женщин (2,2 млн), чем у мужчин (1,8 млн), причем ССЗ являются причиной смерти женщин в 49% случаев, а мужчин -только в 40% случаев [1]. Отмечается также, что эти гендерные различия во многом обусловлены более высоким числом женщин, умирающих от церебро-васкулярных заболеваний, прежде всего от мозгового инсульта (МИ) [1].

show abstract

Metabolic Syndrome and Migraine

Cited by 39 publications

References 152 publications

Migraine Cause And Treatment

Migraine Cause And Treatment

Headache in hyperlipidemia patients

Therapy of Arterial Hypertension and Prevention of Cardiovascular Diseases in Woman of Reproductive Age Suffering From Migraine. Clinical Review

Contact Info

Product

Resources

About