Metabolic Syndrome and Physical Performance in Elderly Men: The Osteoporotic Fractures in Men Study

Everson‐Rose, Susan A.; Paudel, Misti L.; Taylor, Brent C.; Dam, Tien; Cawthon, Peggy M.; LeBlanc, Erin S.; Strotmeyer, Elsa S.; Cauley, Jane A.; Stefanick, Marcia L.; Barrett‐Connor, Elizabeth; Ensrud, Kristine E.

doi:10.1111/j.1532-5415.2011.03518.x

Cited by 21 publications

(23 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evidence also suggests that high cardiometabolic parameters of the MetS are related to physical capacity and mobility in elderly individuals 9,10,30. In the present study, women with the MetS presented lower functional capacity and muscle strength when compared to women without the MetS.…”

Section: Discussionsupporting

confidence: 49%

“…Penninx et al9 revealed that older persons with the MetS displayed a 50% greater chance of developing mobility limitations compared with those without the MetS. Similarly, Everson-Rose et al demonstrated that elderly men with the MetS had an approximately 1-point lower performance score and a 0.04 m/s slower walking speed than men without the MetS 10. Moreover, several investigations in the current literature have shown that individuals with the MetS display lower muscle strength and cardiorespiratory fitness 11–14.…”

Section: Introductionmentioning

confidence: 99%

“…Studies have linked the MetS to physical decline in older persons 9,10. Penninx et al9 revealed that older persons with the MetS displayed a 50% greater chance of developing mobility limitations compared with those without the MetS.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Decreased functional capacity and muscle strength in elderly women with metabolic syndrome

Vieira

Tibana²,

Tajra³

et al. 2013

CIA

View full text Add to dashboard Cite

PurposeTo compare the metabolic parameters, flexibility, muscle strength, functional capacity, and lower limb muscle power of elderly women with and without the metabolic syndrome (MetS).MethodsThis cross-sectional study included 28 older women divided into two groups: with the MetS (n = 14; 67.3 ± 5.5 years; 67.5 ± 16.7 kg; 1.45 ± 0.35 m; 28.0 ± 7.6 kg/m2), and without the MetS (n = 14; 68.7 ± 5.3 years; 58.2 ± 9.9 kg; 1.55 ± 0.10 m; 24.3 ± 3.8 kg/m2). Body composition was evaluated by dual-energy X-ray absorptiometry and dynamic muscle strength was assessed by one-maximum repetition (1RM) tests in leg press, bench press and biceps curl exercises. Six-minute walk test, Timed Up and Go (TUG); 30-second sitting-rising; arm curl using a 2-kg dumbbell, sit-and-reach (flexibility), and vertical jump tests were performed.ResultsThere was no difference between groups regarding age (P = 0.49), height (P = 0.46), body fat (%) (P = 0.19), systolic (P = 0.64), diastolic (P = 0.41) and mean blood pressure (P = 0.86), 30-second sitting-rising (P = 0.57), 30-s arm curl (P = 0.73), leg press 1RM (P = 0.51), bench press 1RM (P = 0.77), and biceps curl 1RM (P = 0.85). However, women without the MetS presented lower body mass (P = 0.001), body mass index (BMI) (P = 0.0001), waist circumference (P = 0.02), waist-to-height ratio (P = 0.02), fat body mass (kg) (P = 0.05), lean body mass (kg) (P = 0.02), blood glucose (P = 0.05), triglycerides (P = 0.03), Z-score for the MetS (P = 0.05), higher high-density lipoprotein-cholesterol (HDL-C) (P = 0.002), better performance on TUG (P = 0.01), flexibility (P = 0.03), six-minute walk test (P = 0.04), vertical jump (P = 0.05) and relative muscle strength for leg press (P = 0.03), bench press (P = 0.04) and biceps curl (P = 0.002) exercises as compared to women with the MetS.ConclusionElderly women with the MetS have higher metabolic risk profile and lower functional capacity, muscle strength, lower limb power and flexibility as compared to women without the MetS. The evaluation of functional capacity may help to determine the degree of physical decline in older persons with the MetS, while exercise interventions should be encouraged.

show abstract

Section: Discussionsupporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Decreased functional capacity and muscle strength in elderly women with metabolic syndrome

Vieira

Tibana²,

Tajra³

et al. 2013

CIA

View full text Add to dashboard Cite

show abstract

“…To avoid overadjustment, the latter two were adjusted for height before inclusion in the model. The model also included adjustment for diabetes (DM), which is known to influence both muscle and bone parameters . Bonferroni correction was retrospectively applied to each association to take account of multiple testing …”

Section: Methodsmentioning

confidence: 99%

Muscle size, strength, and physical performance and their associations with bone structure in the Hertfordshire Cohort Study

Edwards

Gregson²,

Patel

et al. 2013

Journal of Bone and Mineral Research

141

View full text Add to dashboard Cite

Sarcopenia is associated with a greater fracture risk. This relationship was originally thought to be explained by an increased risk of falls in sarcopenic individuals. However, in addition, there is growing evidence of a functional muscle-bone unit in which bone health may be directly influenced by muscle function. Because a definition of sarcopenia encompasses muscle size, strength, and physical performance, we investigated relationships for each of these with bone size, bone density, and bone strength to interrogate these hypotheses further in participants from the Hertfordshire Cohort Study. A total of 313 men and 318 women underwent baseline assessment of health and detailed anthropometric measurements. Muscle strength was measured by grip strength, and physical performance was determined by gait speed. Peripheral quantitative computed tomography (pQCT) examination of the calf and forearm was performed to assess muscle cross-sectional area (mCSA) at the 66% level and bone structure (radius 4% and 66% levels; tibia 4% and 38% levels). Muscle size was positively associated with bone size (distal radius total bone area b ¼ 17. These associations were also seen in men and were maintained after adjustment for age, height, weight-adjusted-for-height, limb-length-adjusted-for-height, social class, smoking status, alcohol consumption, calcium intake, physical activity, diabetes mellitus, and in women, years since menopause and estrogen replacement therapy. Although grip strength showed similar associations with bone size and strength in both sexes, these were substantially attenuated after similar adjustment. Consistent relationships between gait speed and bone structure were not seen. We conclude that although muscle size and grip strength are associated with bone size and strength, relationships between gait speed and bone structure and strength were not apparent in this cohort, supporting a role for the muscle-bone unit.

show abstract

“…The four individual test scores were summed to create an overall physical performance score with a possible range of 0 to 20, where lower scores indicate worse performance. 23 …”

Section: Discussionmentioning

confidence: 99%

Association of Opioids with Falls, Fractures, and Physical Performance among Older Men with Persistent Musculoskeletal Pain

et al. 2016

Self Cite

View full text Add to dashboard Cite

BACKGROUND: Although older adults are disproportionately affected by painful musculoskeletal conditions and receive more opioid analgesics than persons in other age groups, insufficient evidence is available regarding opioid harms in this age group. OBJECTIVE: To examine longitudinal relationships between opioid use and falls, clinical fractures, and changes in physical performance. We hypothesized that opioid use would be associated with greater risks of falling and incident clinical fractures and greater declines in physical performance. DESIGN: We analyzed data from the Osteoporotic Fractures in Men Study (MrOS), a large prospective longitudinal cohort study. Participants completed baseline visits from 2000 to 2002 and were followed for 9.1 (SD 4.0) years. PARTICIPANTS: MrOS enrolled 5994 communitydwelling men ≥ 65 years of age. The present study included 2902 participants with back, hip, or knee pain most or all of the time at baseline. MAIN MEASURES: The exposure of interest was opioid use, defined at each visit as participant-reported daily or near-daily use of any opioid-containing analgesic. Among patients, 309 (13.4 %) reported opioid use at one or more visits. Participants were queried every 4 months about falls and fractures. Physical performance scores were derived from tests of grip strength, chair stands, gait speed, and dynamic balance. KEY RESULTS: In the main analysis, the adjusted risk of falling did not differ significantly between opioid use and non-use groups (RR 1.10, 95 % CI 0.99, 1.24). Similarly, adjusted rates of incident clinical fracture did not differ between groups (HR 1.13, 95 % CI 0.94, 1.36). Physical performance was worse at baseline for the opioid use group, but annualized change in physical performance scores did not differ between groups (−0.022, 95 % CI −0.138, 0.093). CONCLUSIONS: Additional research is needed to determine whether opioid use is a marker of risk or a cause of falls, fractures, and progressive impairment among older adults with persistent pain.

show abstract

Metabolic Syndrome and Physical Performance in Elderly Men: The Osteoporotic Fractures in Men Study

Cited by 21 publications

References 33 publications

Decreased functional capacity and muscle strength in elderly women with metabolic syndrome

Decreased functional capacity and muscle strength in elderly women with metabolic syndrome

Muscle size, strength, and physical performance and their associations with bone structure in the Hertfordshire Cohort Study

Association of Opioids with Falls, Fractures, and Physical Performance among Older Men with Persistent Musculoskeletal Pain

Contact Info

Product

Resources

About